Infection in Burns

Abstract

Background: Developments in critical care and surgical approaches to treating burn wounds, together with newer antimicrobial treatments, have significantly reduced the morbidity and mortality rates associated with this injury. Methods: Review of the pertinent English-language literature. Results: Several resistant organisms have emerged as the maleficent cause of invasive infection in burn patients, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus, Pseudomonas, Acinetobacter, non-albicans Candida spp., and Aspergillus. Advances in antimicrobial therapies and the release of new classes of antibiotics have certainly added to the armamentarium of therapeutic resources for the clinician. Conclusion: Strict infection control measures, constant wound surveillance with regular sampling of tissues for quantitative culture, and early excision and wound closure remain the principal adjuncts to control of invasive infections in burn patients.

3D skin models for 3R research: The potential of 3D reconstructed skin models to study skin barrier function

“…A study using HSE models has shown that reduced expression of filaggrin protein resulted in increased epidermal S. aureus colonization . S. aureus is also a major pathogen in skin infections in burn wound patients, and large efforts are made to prevent and treat wound infections . The expectation is that many studies will investigate the role of micro‐organisms in skin diseases and therapeutic strategies to treat these conditions.…”

Burn Wound Healing and Tissue Engineering

“…(CRE), Pseudomonas spp ., non-albicans Candida spp. , and Aspergillus spp ., have been associated with increased mortality after burns 52,53 . Most of these strains have nosocomial origins, can spread within burn units, and be very difficult to eradicate.…”

“…Most of these strains have nosocomial origins, can spread within burn units, and be very difficult to eradicate. Although a new generation of antimicrobial agents is being developed 52,54 , it is often necessary to use agents with high chemical toxicity, such as chlorhexidine gluconate, which may impede wound healing while controlling wound infection.…”

Nano-Engineered Biomaterials for Tissue Regeneration: What Has Been Achieved So Far?

“…Thus, as similar to the above discussed for DFUs, laboratory engineered materials had been developed to fulfill the need for alternative strategies for wound covering and tissue regeneration in these patients (Ulrich, 2014). Furthermore, the control/prevention of nosocomial infections in burn patients is a pivotal factor for reducing hospital stays and morbidity (Norbury et al, 2016).…”