Infection of Lutzomyia longipalpis in cats infected with Leishmania infantum

Mendonça, Ivete Lopes de; Batista, Joilson Ferreira; Lopes, Kayo Sandro Pimentel do Prado; Neto, Francisco; Alcântara, Diana Sousa; Merigueti, Yslla Fernanda Fitz Balo; Costa, Carlos Henrique Nery

doi:10.1016/j.vetpar.2020.109058

Cited by 16 publications

(27 citation statements)

References 12 publications

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“…In a study developed by Gossage et al (2003), it was observed that L. infantum's metacyclic promastigote (infective form) reaches a high prevalence in the sand fly on the 10 th day after infection. Despite the presence of promastigotes in the probocide of L. longipalpis on the 6 th day after infection (Mendonça et al, 2020), possibly in this study, a small amount of metacyclic promastigotes has infected the dog, favoring the control of the infection by the immune response.…”

Section: Discussionmentioning

confidence: 54%

“…The 15 un-dissected L. longipalpis females were subjected to blood meal sessions on the outside of the dog's ear for 60 min, on the 5 th and the 6 th day after feeding on the feline. The 5 th and 6 th day were chosen because a large amount of Leishmania was observed in the probocide of L. longipalpis on the 6 th day after feeding in a feline infected with L. infantum (Mendonça et al, 2020).…”

Section: Evaluation Of Transmission In the Dogmentioning

confidence: 99%

“…Reports of the disease in domestic cats in the country (Savani et al, 2004;Vides et al, 2011;Coelho et al, 2011;Benassi et al, 2017;Metzdorf et al, 2017;Mendonça et al, 2017a;Asfaram et al, 2019), the demonstration that cats infected with L. infantum have a high capacity to infect Lutzomyia. longipalpis (Mendonça et al, 2020) and the possible transmission of infection from these animals to dogs is of great concern, since, domestic cats have a very close contact with dogs and humans and can be highly important in the spread of leishmaniasis in the urban environment.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies on the role of felines in the VL biological cycle reported potential infections of Phlebotomus perniciosus and L. longipalpis by L. infantum while performing xenodiagnosis on infected feline (Maroli at al., 2007;Silva et al, 2010;Mendonça et al, 2020). However, no previous study has evaluated the possibility of VL transmission from felines to another susceptible host.…”

Section: Introductionmentioning

confidence: 99%

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Transmission of Leishmania infantum from cats to dogs

Batista

Neto

Lopes

et al. 2020

Rev. Bras. Parasitol. Vet.

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Leishmania infantum infection in cats has been reported in several countries, including Brazil. However, the transmission of visceral leishmaniasis (VL) from cats to another host has not been proven yet. Therefore, the aim of this study was to verify the possibility of L. infantum transmission from cats to dogs. In order to verify the possibility of VL transmission from the cat to the dog, xenodiagnosis was carried out in a VL-positive cat, using 55 female Lutzomyia longipalpis. Five days later, 40 insects were dissected to verify Leishmania infection. The remaining 15 females were fed in a healthy dog. The potential infection of the dog was verified through clinical, serological, parasitological examinations, and PCR, at three, six, and twelve months post-infection. All 55 L. longipalpis females became visibly engorged. Leishmania promastigotes were detected in 27.5% of the dissected insects. Leishmania infection in the dog was confirmed upon first evaluation. DNA sequencing of the parasite isolated from the cat confirmed L. infantum infection and showed 99% similarity with the L. infantum DNA sequences from the dogs. Through this study, it was possible to confirm the L. infantum experimental transmission from a domestic cat to a domestic dog through its biological vector L. longipalpis.

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Section: Discussionmentioning

confidence: 54%

Section: Evaluation Of Transmission In the Dogmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Transmission of Leishmania infantum from cats to dogs

Batista

Neto

Lopes

et al. 2020

Rev. Bras. Parasitol. Vet.

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“…The domestic dog is considered the main reservoir of visceral leishmaniasis in the urban environment (Solano-Gallego et al, 2009). Domestic cats can also be infected and manifest the disease, but the epidemiology has not been clearly established (Hoogstraal & Dietlein, 1964); they are capable of infecting sand flies and acting as reservoir hosts (Mendonça et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Natural Infection by Leishmania infantum in domestic cats (Felis catus) in a municipality of moderate transmission in the Brazilian semi-arid region

Silva

Portela

Arruda

et al. 2020

Rev. Bras. Parasitol. Vet.

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The main clinical, anatomopathological, and molecular aspects of the infection by Leishmania infantum are described in two cats with multicentric cutaneous, nodular, and ulcerated lesions. The animals were submitted to a clinical examination, followed by serological, molecular and parasitological exams, with culture and isolation of the parasite, and subsequent isoenzymatic characterization. The animals were euthanized and necropsied. Case 1 was an adult, female, mixed-bred stray cat. Case 2 was an adult, male, mixed-bred and domiciled cat. Both were positive for the presence of anti-L. infantum antibodies. In the cytology of the cutaneous nodules and lymph nodes, amastigote forms of Leishmania spp. could be visualized, free and in the interior of the macrophages. In the histopathology, the lesions were characterized by nodular granulomatous and/or ulcerative dermatitis, associated to amastigote forms of Leishmania spp. By means of the polymerase chain reaction, the sequence of the L. infantum kDNA minicircle was amplified. It is concluded that the infection by L. infantum occurs in cats in the State of Paraíba, Northeast region of Brazil and the need to understand the immunological profile of the visceral leishmaniasis in the feline population is highlighted with aimed at the control measures in public health.

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