2008
DOI: 10.1371/journal.pone.0001792
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Infection of Semen-Producing Organs by SIV during the Acute and Chronic Stages of the Disease

Abstract: BackgroundAlthough indirect evidence suggests the male genital tract as a possible source of persistent HIV shedding in semen during antiretroviral therapy, this phenomenon is poorly understood due to the difficulty of sampling semen-producing organs in HIV+ asymptomatic individuals.Methodology/Principal FindingsUsing a range of molecular and cell biological techniques, this study investigates SIV infection within reproductive organs of macaques during the acute and chronic stages of the disease. We demonstrat… Show more

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Cited by 59 publications
(123 citation statements)
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“…Indirect arguments that suggest that the seminal vesicles represent an important contributor to HIV shedding in semen are that selective sampling of genital fluids from HIV-positive men and prostate biopsy specimens indicated distal genitourinary sources other than the prostate gland (ie, seminal vesicles, urethra, and/or associated glands) as the major sources of seminal HIV in men without urethritis or prostatitis, 21 and in animal models, seminal vesicle infection by SIV was detected in rhesus macaques with AIDS 22,23 and in asymptomatic cynomolgus macaques. 15 To date, HIV infection of human seminal vesicles has not been reported. The only data available are from an early study of patients with AIDS that failed to detect HIV nucleic acids in the seminal vesicles of the three individuals tested using in situ PCR.…”
Section: Discussionmentioning
confidence: 99%
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“…Indirect arguments that suggest that the seminal vesicles represent an important contributor to HIV shedding in semen are that selective sampling of genital fluids from HIV-positive men and prostate biopsy specimens indicated distal genitourinary sources other than the prostate gland (ie, seminal vesicles, urethra, and/or associated glands) as the major sources of seminal HIV in men without urethritis or prostatitis, 21 and in animal models, seminal vesicle infection by SIV was detected in rhesus macaques with AIDS 22,23 and in asymptomatic cynomolgus macaques. 15 To date, HIV infection of human seminal vesicles has not been reported. The only data available are from an early study of patients with AIDS that failed to detect HIV nucleic acids in the seminal vesicles of the three individuals tested using in situ PCR.…”
Section: Discussionmentioning
confidence: 99%
“…We recently demonstrated that the seminal vesicles of asymptomatic macaques are productively infected by simian immunodeficiency virus (SIV) in vivo and, together with the prostate, exhibit the highest level of infection among the male genital tract organs in this animal model. 15 To date, infection of human seminal vesicles by HIV has not been reported. …”
mentioning
confidence: 99%
“…In vivo, l'infection de cet organe a été mise en évidence dans un modèle animal qui mime l'infection chez l'homme -les macaques cynomolgus infectés par le SIV (virus de l'immunodéficience simienne). Le SIV infecte le testicule dès la primo-infection et persiste au stade chronique [32]. Les principales cellules infectées sont des lymphocytes T et des macrophages présents dans le tissu interstitiel.…”
Section: Organes Du Tractus Génital Masculin Et Vihunclassified
“…Le modèle macaque a également permis de révéler l'infection par le SIV de l'épididyme, de la prostate et de la vésicule séminale. Comme dans le cas du testicule, l'infection de ces organes survient de façon précoce, pendant la primo-infection, et elle est retrouvée pendant la phase chronique asymptomatique [32] (Figure 3). Dans l'ensemble des organes, les cellules infectées sont majoritairement des lymphocytes T isolés, et dans une moindre mesure des macrophages, localisés principalement dans le stroma des organes, mais aussi insérés vers la lumière entre les cellules épithéliales.…”
Section: Organes Du Tractus Génital Masculin Et Vihunclassified
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