Infections and non‐neoplastic diseases of the oral mucosa

Js, Greenspan

doi:10.1111/j.1600-0714.1983.tb00329.x

Cited by 10 publications

(2 citation statements)

References 155 publications

(108 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on the same data, 56% of the patients told that they had never suffered from facial/labial HSV infection but on the other hand 15% had it more than twice a year. This finding is in agreement with other writers (37,38). Exfoliative cytology has been widely used on female genital tract to screen various disease entities, but in oral pathology, cytology has never gained wider use.…”

Section: Discussionsupporting

confidence: 94%

Oral mucosal changes in women with genital HPV infection

Kellokoski

Syrjänen

et al. 1990

J Oral Pathology Medicine

View full text Add to dashboard Cite

Sixty different types of human papillomavirus (HPV) are currently recognized. Of these, HPV types 1, 2, 4, 6, 7, 11, 13, 16, 18, 30, 32 and 57 have been identified in oral squamous cell lesions. The prevalence and incidence of clinical HPV infections of oral mucosa are incompletely established, and the figures on subclinical and latent infections are completely lacking. Similarly, no data exist on transmission of oral HPV infections. A long-term prospective follow-up study was started to assess the oral mucosal changes related to HPV infection in women with genital HPV infections. The aim was to elucidate whether genital HPV infections predispose the oral mucosa to this virus. This study reports the clinical, histologic and cytologic findings of oral mucosa as related to the genital status of 334 women prospectively followed-up in Kuopio University Central Hospital since 1981. At the time of examination, 5% presented with hand warts. Clinical wart in oral cavity was found in three patients (0.9%) only. Oral mucosa was clinically normal in 207 of 334 (62%) patients examined. Biopsies (n = 255) were taken from the buccal mucosa beneath the linea alba and above the sulcus in the region of the first molar, or from a lesion whenever present. Cytologic scrapings were taken from both sides of the buccal mucosa. Koilocytes were found in 0.9% of the cytologic scrapings, and in 9.4% of the biopsies. Altogether, four squamous cell papillomas and five flat condylomas were found in the biopsies. Morphologic changes suggestive for HPV were present in 25 biopsies. Hyperkeratosis proved to be a frequent finding (34%) in these biopsies.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

Section: Discussionsupporting

confidence: 94%

Oral mucosal changes in women with genital HPV infection

Kellokoski

Syrjänen

et al. 1990

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

“…Of the 75 patients, 66% had RAU lesions of the more severe herpetiform or major types. Estimates in the literature from before the advent of the AIDS epidemic suggest that minor RAU comprised about 80% of all cases, whereas major and herpetiform RAU together comprised only about 20% (Lehner 1977;Greenspan, 1983;Rogers and Hutton, 1986;Hutton and Rogers, 1987). Given that the OAC Clinic specializes in unusual oral problems, seeing persons with severe RAU is not unexpected.…”

Section: Introductionmentioning

confidence: 99%

Oral ulceration in HIV infection: Investigation and pathogenesis

MacPhail

1997

Oral Diseases

View full text Add to dashboard Cite

Oral ulcerations associated with HIV infection include recurrent aphthous ulcers (RAU). Whereas RAU prevalence is not increased, lesion severity is: among a group of HIV+ patients, 66% had the more severe herpetiform or major RAU. This increased severity suggests that HIV disease-related changes in the immune system may exacerbate RAU. In the peripheral blood of healthy subjects with RAU, CD4:CD8 cell ratios may be reversed and the proportion of T cell receptor-gamma delta + cells increased. HIV disease-related immune system changes are characterized by reversed CD4:CD8, lowered CD4 cell counts and an inverse correlation between CD4 cell counts and per cent activated gamma delta lymphocytes. Adhesion molecules and cytokines involved in lymphocyte homing may be important in RAU pathogenesis: ICAM-I and ELAM are strongly expressed, and TNF alpha production is increased in peripheral blood lymphocytes of healthy patients with RAU. In patients with active HIV disease/AIDS, serum TNF alpha levels are increased. Thalidomide, which inhibits TNF alpha production, is effective treatment for RAU. Some RAU patients have vitamin B12 or folate deficiencies, levels of which are commonly low in HIV+/AIDS patients. However, in a case control study of HIV+ patients, vitamin B12- or folate-deficiencies were not found to be significant risk factors for RAU.

show abstract

Metabolische Veränderungen

Seifert¹

2000

Oralpathologie

View full text Add to dashboard Cite

Infections and non‐neoplastic diseases of the oral mucosa

Cited by 10 publications

References 155 publications

Oral mucosal changes in women with genital HPV infection

Oral mucosal changes in women with genital HPV infection

Oral ulceration in HIV infection: Investigation and pathogenesis

Metabolische Veränderungen

Contact Info

Product

Resources

About