Infections caused by extended-spectrum beta-lactamases producing Enterobacteriaceae: clinical and economic impact in patients hospitalized in 2 teaching hospitals in Dakar, Senegal

Ndir, Awa; Diop, Amadou; Ka, R.; Faye, P. M.; Dia-Badiane, Ndèye Méry; Ndoye, B; Astagneau, Pascal

doi:10.1186/s13756-016-0114-7

Cited by 41 publications

(30 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…14 From our observations, the mortality ratio in Obstetrics versus Gynecology cases is 1: 11.2 or in other words, Gynecological patients with SSI and ESBL (+) have a 11.2x chance of dying than in Obstetrics. This is in accordance with the results of a study from Senegal which states that SSI cases with ESBL (+) and comorbid malignancies have a higher Case Fatality Rate (16).…”

Section: Resultssupporting

confidence: 92%

Pattern of disease and type of operation of Surgical Site Infection in obstetrics and gynecology at Dr Soetomo Hospital, Surabaya, Indonesia

Marsanto

Kuntaman

Paraton

et al. 2019

MOG

View full text Add to dashboard Cite

ABSTRAKObjectives: to find correlation between risk factors and classification of SSI, the distribution of SSI, and cost in Soetomo Hospital. Materials and Methods: descriptive retrospective observational with correlation analysis between risk factors and SSI classification according to Centers for Disease Control (CDC) definition with univariate analysis. Sub-group descriptive analysis on microbiology result, length of stay (LOS) and cost was also performed. All patients was diagnosed SSI between January 2015 until June 2017. Results: age, referral cases, Body Mass Index, Hemoglobin and Albumin results, types of surgery, types of case are the risk factors we included. Analysis result shows no strong and significance correlation in all risk factors (r 0.053 -0.447; p 0.072 -0.971). According to SSI types, the distribution are: superficial (7; 13.2%), deep (26; 49.1%), organ/space (20; 37.7%). Extended-Spectrum Beta-Lactamase (ESBL) was obtained in 19 (14 Obstetrics; 5 Gynecology) from 28 patients with microbiology results. Five deaths occured in ESBL patients (1 Obstetrics; 4 Gynecology; ratio 1 : 11.2). Mean length of stay in Obstetrics and Gynecology was 41.7 and 19.2 days, respectively. Mean cost per day in Obstetrics and Gynecology was 1.2 amd 2.6 million rupiah, respectively. Conclusions: no strong and significant results in all risk factors. Death rate in SSI and malignancy with positive ESBL result are high. Less cost needed for SSI patients, but with longer LOS. Comprehensive approaches are needed to patients at risk of SSI, further study with larger sample are needed.Tujuan: mengetahui hubungan antara faktor resiko dengan derajat keparahan SSI, distribusi SSI, dan biaya yang diperlukan. Bahan dan Metode: deskriptif retrospektif observasional dengan analisis faktor resiko dan hubungan dengan jenis SSI. Dilakukan analisis sub grup terhadap hasil biakan kuman, lama masa inap dan biaya yang diperlukan. Hasil: usia, rujukan, indeks massa tubuh, kadar Hb, Albumin, setting operasi, dan jenis kasus merupakan faktor resiko yang kami pilih. Hasil analisis menunjukkan tidak ada korelasi yang kuat dan kemaknaan pada semua faktor resiko (r 0,053 -0,447; p 0,072 -0,971). Distribusi SSI menurut jenisnya: superficial (7; 13,2%), deep (26; 49,1%), organ/space (20; 37,7%). Kuman dengan Extended-Spectrum Beta-Lactamase (ESBL) didapatkan pada 19 (14 Obstetri; 5 Ginekologi) dari 28 pasien dengan biakan kuman. Lima kematian pada SSI dengan ESBL (1 Obstetri; 4 Ginekologi). Rerata masa inap pada Obstetri dan Ginekologi 41,7 dan 19,2 hari. Rerata biaya per hari untuk Obstetri dan Ginekologi berurutan 1,2 dan 2,6 juta rupiah. Kesimpulan: tidak ada faktor resiko yang bermakna dengan korelasi yang kuat. Kematian pada pasien SSI dan keganasan dengan hasil biakan kuman ESBL (+) sangat tinggi. Biaya yang diperlukan untuk merawat pasien dengan SSI lebih sedikit namun dengan masa rawat inap yang jauh lebih lama. Diperlukan penanganan yang lebih komprehensif terhadap pasien dengan resiko SSI dan studi lebih lanjut dengan sampel yang lebi...

show abstract

Section: Resultssupporting

confidence: 92%

Pattern of disease and type of operation of Surgical Site Infection in obstetrics and gynecology at Dr Soetomo Hospital, Surabaya, Indonesia

Marsanto

Kuntaman

Paraton

et al. 2019

MOG

View full text Add to dashboard Cite

show abstract

“…151 However, multidrug-resistant ESBLproducing organisms observed in several studies are usually acquired from contaminated hospital environments, 152 with increased risk of mortality, especially among preterm babies. 153 In Mali, typing of ESBL Enterobacteriaceae among bacteraemic children and adults from two referral hospitals showed a high rate of cross transmission between patients and the spread of strains from one hospital to another due to patient transfers. 154 This finding underlines the crucial need for…”

Section: Discussionmentioning

confidence: 99%

Aetiology of invasive bacterial infection and antimicrobial resistance in neonates in sub-Saharan Africa: a systematic review and meta-analysis in line with the STROBE-NI reporting guidelines

Okomo

Akpalu

Doaré

et al. 2019

The Lancet Infectious Diseases

186

207

View full text Add to dashboard Cite

Background Aetiological data for neonatal infections are essential to inform policies and programme strategies, but such data are scarce from sub-Saharan Africa. We therefore completed a systematic review and meta-analysis of available data from the African continent since 1980, with a focus on regional differences in aetiology and antimicrobial resistance (AMR) in the past decade (2008-18). Methods We included data for microbiologically confirmed invasive bacterial infection including meningitis and AMR among neonates in sub-Saharan Africa and assessed the quality of scientific reporting according to Strengthening the Reporting of Observational Studies in Epidemiology for Newborn Infection (STROBE-NI) checklist. We calculated pooled proportions for reported bacterial isolates and AMR. Findings We included 151 studies comprising data from 84 534 neonates from 26 countries, almost all of which were hospital-based. Of the 82 studies published between 2008 and 2018, insufficient details were reported regarding most STROBE-NI items. Regarding culture positive bacteraemia or sepsis, Staphylococcus aureus, Klebsiella spp, and Escherichia coli accounted for 25% (95% CI 21-29), 21% (16-27), and 10% (8-10) respectively. For meningitis, the predominant identified causes were group B streptococcus 25% (16-33), Streptococcus pneumoniae 17% (9-6), and S aureus 12% (3-25). Resistance to WHO recommended β-lactams was reported in 614 (68%) of 904 cases and resistance to aminoglycosides in 317 (27%) of 1176 cases. Interpretation Hospital-acquired neonatal infections and AMR are a major burden in Africa. More population-based neonatal infection studies and improved routine surveillance are needed to improve clinical care, plan health systems approaches, and address AMR. Future studies should be reported according to standardised reporting guidelines, such as STROBE-NI, to aid comparability and reduce research waste.

show abstract

“…Hijazi et al (2016) also reported a similar finding in Lebanon with male children having a higher colonization frequency (33.9%) of ESBL-E in contrast to their female counterparts that had a frequency of (15.9%). However this observation is a deviation from the normal trend of having more bacterial isolates from female urine samples since they were more at risk of acquiring urinary tract infection compared to their male counterparts (Ameri et al, 2014 (Ndir et al, 2016). Antibiotic resistance is a global problem which varies across countries as a result of hygiene levels in hospital and antibiotic management policies.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and resistance profile of extended-spectrum -lactamases-producing Enterobacteriaceae in Ouagadougou, Burkina Faso

Kpoda¹,

Nathalie²,

Bonkoungou³

et al. 2017

Afr. J. Microbiol. Res.

View full text Add to dashboard Cite

Increasing bacterial resistance to antimicrobial agents has become an issue of concern. A major problem of the treatment of infections caused by Enterobacteriaceae using antibiotics is the emergence of Extended-spectrum β-lactamases (ESBL)-producing Enterobacteriaceae. This study aims to determine the prevalence of ESBL-producing Enterobacteriaceae strains in Ouagadougou, Burkina Faso, and describe their resistance profile to other antibiotics commonly used in the infections treatment. 486 clinical strains of Enterobacteriaceae were obtained from patients attending three health centers in Ouagadougou (Burkina Faso) from November 2014 to October 2015. Biochemical identification was performed and antibiotics susceptibility test was performed using the disk diffusion method. Data was analyzed with the Excel and ANOVA one-way software GraphPad Prism version 5.01 software. Results revealed occurrence of Escherichia coli (60.9%, 194) predominated followed by Klebsiella spp. (22.4%, 109). Antibiotics susceptibility test revealed that 86.8% strains were resistant to amoxicillin, 81.3% to trimethoprim-sulfamethoxazole, 61.9% to ceftriaxone, 58.6% to cefotaxime and 58.4% to cefepime. It was observed that 99.8% were susceptible to imipenem while 16.6% were resistant to fosfomycin and 12.3% to amikacin. However, 38.5% (187/486) of the strains were ESBL-producing, 67.9% (127/187) of which came from Yalgado Ouedraogo University Hospital Center, 23.5% (44/187) from Charles De Gaulle Paediatric University Hospital Center and 8.6% (16/187) from Saint Camille Hospital. This study thus showed a high prevalence of Extended-Spectrum Β-Lactamases producing Enterobacteriaceae strains in Ouagadougou (38.5%). It underlined the need for routine detection and systematic reporting of ESBL strains in different health facilities in Burkina Faso, so that measures could be taken to prevent their spread and treatment failures.

show abstract

Infections caused by extended-spectrum beta-lactamases producing Enterobacteriaceae: clinical and economic impact in patients hospitalized in 2 teaching hospitals in Dakar, Senegal

Cited by 41 publications

References 30 publications

Pattern of disease and type of operation of Surgical Site Infection in obstetrics and gynecology at Dr Soetomo Hospital, Surabaya, Indonesia

Pattern of disease and type of operation of Surgical Site Infection in obstetrics and gynecology at Dr Soetomo Hospital, Surabaya, Indonesia

Aetiology of invasive bacterial infection and antimicrobial resistance in neonates in sub-Saharan Africa: a systematic review and meta-analysis in line with the STROBE-NI reporting guidelines

Prevalence and resistance profile of extended-spectrum -lactamases-producing Enterobacteriaceae in Ouagadougou, Burkina Faso

Contact Info

Product

Resources

About