Infections diagnosed in the first year after pediatric stem cell transplantation

Abstract

The incidence of infection immediately after transplantation did not differ significantly by type of transplant in this pediatric population. Type of transplant predicted increased incidence of infection 30 days posttransplantation and increased incidence of infection with several organisms traditionally associated with a high mortality rate in the transplant population.

Predictors of invasive fungal infection in pediatric allogeneic hematopoietic SCT recipients

“…[1][2][3][4][5][6] We may still have underestimated the true incidence of IFI due to a conservative definition of IFI and the fact that autopsy was not always performed. Interestingly, despite changes in our hospital in prophylactic strategies as of 2008 towards the use of more mould-active antifungal agents, the incidence of IFI did not decrease.…”

“…as used in our institution, was based on available literature [1][2][3][4][5][6] and includes pre-and post-HSCT criteria. For this study, we retrospectively classified all patients into high-or low-risk groups using the same criteria.…”

“…[1][2][3][4][5][6][7][8][9][10] Based on prior studies, IFI is estimated to occur in 8-17% of pediatric HSCT patients, with a mortality rate of 35-50%. [1][2][3][4][5][6] Incidence varies in the different post-transplant phases, with peaks both pre-and post-engraftment. 7,11 Invasive aspergillosis, invasive candidiasis and zygomycosis are the most common types of IFI.…”

“…[1][2][3][4][5][6] Post-HSCT, GVHD, viral reactivations and use of high-dose steroids are possibly related to the occurrence of IFI. [1][2][3][4][5][6][7][8][9][10] However, studies that focus on pediatric patients are scarce, use relatively small cohorts and are possibly outdated as advances in prophylactic and diagnostic strategies have been made. Therefore, we performed a risk factor analysis on a large cohort of pediatric patients from a single center.…”

Risks and outcomes of invasive fungal infections in pediatric patients undergoing allogeneic hematopoietic cell transplantation

“…Several retrospective pediatric reviews have reported incidence rates of documented IFI ranging from 6 to 12%, with overall mortality rates of 4-14%. [7][8][9] Many patients in need of allogeneic HCT have undergone intensive pre-transplant chemotherapy regimens and have experienced a prior IFI. Although several case series describe the outcome of adults with prior IFI who undergo HCT, [10][11][12][13] there are only sporadic case reports in the pediatric population.…”