Other Viral Infections After Hematopoietic Cell Transplantation

Boeckh, Michael

doi:10.1002/9780470987070.ch57

Cited by 3 publications

(2 citation statements)

References 141 publications

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“… Monthly distribution of respiratory syncytial virus (RSV), parainfluenza virus 3, and influenza infections after HCT in the 1990’s at the Fred Hutchinson Cancer Research Center [from Boeckh (2004)]. With permission from Blackwell Publishing, Oxford, UK.…”

Section: Respiratory Syncytial Virusmentioning

confidence: 99%

The challenge of respiratory virus infections in hematopoietic cell transplant recipients

2008

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SummaryRespiratory virus infections in hematopoietic cell transplant (HCT) recipients are a major cause of morbidity and mortality. While respiratory syncytial virus (RSV), human metapneumonvirus, parainfluenzaviruses, and influenza viruses are well known for their potential to cause fatal pneumonia, information has only recently emerged regarding the significance of the newly discovered viruses, such as human coronaviruses NL63 and HKU1, and human bocavirus. Lymphopenia seems to be the most important risk factor for progression to lower respiratory tract disease. Airflow obstruction is another complication of respiratory virus infections after HCT, and data to date indicate this complication may occur following parainfluenza virus and RSV infection. Infection control procedures are key for prevention. Unfortunately, there are no randomized treatment studies, which make the interpretation of the literature on interventions difficult. This article reviews the spectrum of pathogens, epidemiology, risk factors and clinical manifestations of infection, as well as recent advances in diagnostic and clinical management.

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Section: Respiratory Syncytial Virusmentioning

confidence: 99%

The challenge of respiratory virus infections in hematopoietic cell transplant recipients

2008

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“…However, all immunocompromised patients are at high risk for severe lower respiratory tract disease, which often presents as interstitial pneumonia [1,2]. RSV pneumonia is associated with high morbidity and mortality after hematopoietic stem cell transplantation [3]. Although it is known that RSV upper respiratory tract infection (URTI) early after transplantation has a high risk of progression to pneumonia, there are limited data regarding the natural history of pretransplantation RSV infection.…”

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confidence: 99%

Pretransplantation Respiratory Syncytial Virus Infection: Impact of a Strategy to Delay Transplantation

Peck

Corey

Boeckh

2004

Clinical Infectious Diseases

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In patients with pretransplantation RSV URTI, delay of HSCT was associated with a lower risk of pneumonia than was no delay. Because URTIs can progress to severe complications in patients receiving HSCTs, these results support Centers for Disease Control and Prevention/American Society of Blood and Marrow Transplantation recommendations that HSCT be delayed on the basis of symptoms of URTI rather than waiting for virologic confirmation.

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Adenovirus Fulminant Hepatic Failure: Disseminated Adenovirus Disease after Unrelated Allogeneic Stem Cell Transplantation for Acute Lymphoblastic Leukemia

et al. 2006

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Other Viral Infections After Hematopoietic Cell Transplantation

Cited by 3 publications

References 141 publications

The challenge of respiratory virus infections in hematopoietic cell transplant recipients

The challenge of respiratory virus infections in hematopoietic cell transplant recipients

Pretransplantation Respiratory Syncytial Virus Infection: Impact of a Strategy to Delay Transplantation

Adenovirus Fulminant Hepatic Failure: Disseminated Adenovirus Disease after Unrelated Allogeneic Stem Cell Transplantation for Acute Lymphoblastic Leukemia

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