Infections in a pediatric patient cohort with acute lymphoblastic leukemia during the entire course of treatment

Katsimpardi, Katerina; Papadakis, Vassilios; Pangalis, A.; Parcharidou, Agapi; Panagiotou, John P.; Soutis, Michael; Papandreou, Evangelos; Polychronopoulou, Sophia; Haidas, S

doi:10.1007/s00520-005-0884-6

Cited by 60 publications

(61 citation statements)

References 21 publications

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“…Gram positive organism Staphylococcus aureus also contributed in 2 (22.22%) occasions in this study. is is comparable to Katerina Katsimpardiet al 26 which also showed predominance of gram negative organism (Pseudomonas , K pneumonia and E coli). Chessell MJ and Leiper AD showed that the organism responsible for most infections were Pseudomonas aeroginosa followed by Staphylococcus aureus and E coli 24 , whereas Meir et al 27 found gram positive cocci followed by gram negative bacilli in most of the cases.…”

Section: Discussionsupporting

confidence: 82%

“…24 Cwiekliska M et al also found 40%-50% incidence of infection in their study. 25 In another previous study done by Katsimpardi K et al 26 showed that Pseudomonas aeroginosa, Klebsilla pneumonia and E coli were the organisms most commonly isolated. Meir et al 27 found 37% microbiologically documented infection where gram positive cocci followed by gram negative bacilli were isolated in most of the cases.…”

Section: Discussionmentioning

confidence: 92%

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Infections during high dose methotrexate therapy in childhood acute lymphoblastic leukemia (ALL)

et al. 2016

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 92%

Infections during high dose methotrexate therapy in childhood acute lymphoblastic leukemia (ALL)

et al. 2016

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“…The delay in care seeking probably explains the higher complication rate seen in our study. Before the introduction of antiviral therapy, the mortality rate of VZI in children with cancer was reported to be 7%-10%, with rates reaching up to 55% in cases with visceral involvement [5,21,22]. The majority of our patients recovered from the disease and its complications, with an overall recovery rate of 97%.…”

Section: Discussionmentioning

confidence: 75%

Risk factors for complicated varicella infection in pediatric oncology patients at a tertiary health care facility in Pakistan

Alam

Qamar

Khan

et al. 2014

J Infect Dev Ctries

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Introduction: Varicella zoster infection(VZI) is well recognized as a potential cause of morbidity and mortality in immunocompromised pediatric oncology patients (POP). The purpose of this study was to describe the clinical profile and risk factors for complications and outcomes of VZI in POP treated with acyclovir. Methodology: Medical records of all POP with a discharge diagnosis of VZI over a period of seven years (2005)(2006)(2007)(2008)(2009)(2010)(2011) were reviewed. The demographic features, underlying malignancy, risk factors for VZI, complications, and outcomes were recorded. Results: Thirty-six POP with VZI were identified. Leukemia was the most common underlying malignancy (n = 20, 58.8%), followed by lymphoma (n = 7, 20.6%) and solid organ tumors (n = 7, 20.6%). Most of the cases (41%) were observed in children under five. All patients were treated with acyclovir. Varicella-related complications developed in 10 (29%) patients. The most frequent complication was bloodstream infection (n = 3, 8.8%), followed by pneumonia (n = 2, 5.9%), skin infection (n = 2, 5.9%), hepatitis, renal failure, and encephalitis. Independent risk factors associated with complications were age < five years, weight for age < fifth percentile, delay in seeking care (> seven days after onset of symptoms) and severe neutropenia (ANC < 500/cm). One child died secondary to varicella encephalitis. Conclusion: Our data suggests that young age, poor health-seeking behavior, severe neutropenia, and being underweight are the major risk factors for the development of varicella-related complications in POP in developing countries. These complications could be favorably modified through active immunization of immunocompetent children.

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“…Infection is the most frequent complication during chemotherapy for ALL [15]. Especially, remission induction therapy is often complicated by severe myelosuppression, and infection in this phase is sometimes causative of therapy-related death.…”

Section: Discussionmentioning

confidence: 99%

Suppressed neutrophil function in children with acute lymphoblastic leukemia

et al. 2009

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Infection is a major obstacle in cancer chemotherapy. Neutropenia has been considered to be the most important risk factor for severe infection; however, other factors, such as impaired neutrophil function, may be involved in susceptibility to infection in patients undergoing chemotherapy. In this study, we analyzed neutrophil function in children with acute lymphoblastic leukemia (ALL). Whole blood samples were obtained from 16 children with ALL at diagnosis, after induction chemotherapy, and after consolidation chemotherapy. Oxidative burst and phagocytic activity of neutrophils were analyzed by flow cytometry. Oxidative burst of neutrophils was impaired in ALL patients. The percentage of neutrophils with normal oxidative burst after PMA stimulation was 59.0 +/- 13.2 or 70.0 +/- 21.0% at diagnosis or after induction chemotherapy, respectively, which was significantly lower compared with 93.8 +/- 6.1% in healthy control subjects (P = 0.00004, or 0.002, respectively); however, this value was normal after consolidation chemotherapy. No significant differences were noted in phagocytic activity in children with ALL compared with healthy control subjects. Impaired oxidative burst of neutrophils may be one risk factor for infections in children with ALL, especially in the initial periods of treatment.

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Infections in a pediatric patient cohort with acute lymphoblastic leukemia during the entire course of treatment

Cited by 60 publications

References 21 publications

Infections during high dose methotrexate therapy in childhood acute lymphoblastic leukemia (ALL)

Infections during high dose methotrexate therapy in childhood acute lymphoblastic leukemia (ALL)

Risk factors for complicated varicella infection in pediatric oncology patients at a tertiary health care facility in Pakistan

Suppressed neutrophil function in children with acute lymphoblastic leukemia

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