Infections of the Nose and Paranasal Sinuses in Adult Patients With Immunodeficiency

Karlsson, Göran; Petruson, Björn; Björkander, Janne; Hanson, Lars Å.

doi:10.1001/archotol.1985.00800070042003

Cited by 36 publications

(24 citation statements)

References 12 publications

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“…586,587 CVID, X-linked hypogammaglobulinemia, and several other disorders of humoral immunity are frequently referenced as contributing factors to chronic or recurrent recalcitrant RS. 15,588,589,[596][597][598][599] A number of selective Ig deficiencies, specifically those involving IgG3 subclass, IgA, and IgM, have been consistently identified in this group of patients. 585,586,590,593,594,[596][597][598][600][601][602] Preimmunization antipneumococcal titers have been shown to be decreased as well, particularly in patients with the more severe forms of immunodeficiency such as CVID.…”

Section: Discussionmentioning

confidence: 93%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

559

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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Section: Discussionmentioning

confidence: 93%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

559

888

View full text Add to dashboard Cite

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“…A similar study done by Cunningham-Rundles and Bodian (17) showed that 243 out of 248 patients with CVID (98%) had recurrent sinusitis, otitis, or bronchitis, and according to another study in 1989 (18), 22% had developed chronic lung disease. Also, some studies show that resistant sinus infection can frequently be the first presenting symptom in immune deficiencies, especially antibody deficiencies (10,38,48), and the infections of the upper respiratory tract occur several years before the appearance of lower respiratory tract infections (34). Once the infections of the lower respiratory tract have started, the patients neglect the symptoms from the upper respiratory tract.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Immunological Features of 65 Iranian Patients with Common Variable Immunodeficiency

Aghamohammadi

Farhoudi

Moin

et al. 2005

Clin Vaccine Immunol

112

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Common variable immunodeficiency (CVID) is a primary immunodeficiency disease characterized by hypogammaglobulinemia and recurrent bacterial infections. The records of 65 patients with CVID (37 males and 28 females) in the age range of 24 to 537 months were reviewed. By the year 2003, 11 patients had died and seven patients could not be located. The total follow-up period was 221 patient-years. The median diagnostic delay (time between onset and diagnosis) in our patient group was 60 months. At the time of diagnosis, the baseline serum immunoglobulin G (IgG), IgM, and IgA levels were below the level normal for the patients' age; the medians for this group were 120, 10, and 0 mg/dl, respectively. All of the patients presented with infectious diseases at the time of onset, the most common of which were otitis media, diarrhea, pneumonia, and sinusitis. Acute and recurrent infections were also found in almost all of the patients, particularly involving respiratory and gastrointestinal systems. The most common infections, before diagnosis and during follow-up, were pneumonia, acute diarrhea, acute sinusitis, and otitis media. CVID should be considered in any patient with a history of recurrent infections and decreased levels of all serum immunoglobulin isotypes.

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“…Fifteen subjects (9 females and 6 males, mean age 36.5 years, range 17-64 years) of a group of 18 clinically well-characterized IgA-deficient patients [4] were included in this study. The serum le vel of IgA was < 0.05 g/1 in all patients (normal > 0.7 g/1).…”

Section: Patientsmentioning

confidence: 99%

Immunohistochemical Study of Nasal Mucosa in Patients with Selective IgA Deficiency

Brandtzæg

Karlsson

Hansson

et al. 1987

Int Arch Allergy Immunol

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Fifteen nasal biopsy specimens from adult patients with selective IgA deficiency were examined in a ‘blind’ immunohistochemical study for the presence of immunocytes producing various immunoglobulin (Ig) classes. Three groups of patients could be identified. One group had a predominance of IgG- and IgM-producing cells in their nasal mucosa, a second group revealed mainly IgG- and IgD-producing cells, and a third group had very few mucosal immunocytes. The clinical examinations showed that upper respiratory tract infections were most common in patients with few immunocytes while such infections were least common in patients with predominance of IgG and IgM immunocytes. Our results indicated that IgM, in contrast to IgD, acts as a compensatory secretory Ig in some patients with selective IgA deficiency.

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Infections of the Nose and Paranasal Sinuses in Adult Patients With Immunodeficiency

Cited by 36 publications

References 12 publications

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Clinical and Immunological Features of 65 Iranian Patients with Common Variable Immunodeficiency

Immunohistochemical Study of Nasal Mucosa in Patients with Selective IgA Deficiency

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