Infectious Lung Diseases and Endogenous Oxidative Stress

Sarkar, Kamalesh; Sil, Parames C.

doi:10.1007/978-981-13-8413-4_7

Cited by 4 publications

(4 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased lipid peroxidation due to ROS accumulation and oxidative stress causes elevated malondialdehyde (MDA) levels. 7,8 An essential nutrient called Omega-3 has antiinflammatory and antioxidant properties that are important for human health. 6,10 Specifically, peribronchial inflammation and cell death are reduced by Omega-3 in terms of lung pathology.…”

Section: Original Articlementioning

confidence: 99%

“…Through pathogen recognition (PRRs) and NF-B transcription, neutrophils activate innate immunity, which causes the release of proinflammatory cytokines and the expansion of other immune cells to the site of infection. 7,8 Antioxidants such as glutathione peroxide (GPx), glutathione (GSH), and superoxide dismutase (SOD) are present at low levels and ineffective in pneumonia patients. 9,10 The production of reactive oxygen-species (ROS) exceeds the antioxidant capacity, potentially causing damage, which is known…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Role of Omega-3 on the IL-6 Levels, Malondialdehyde, and Clinical Improvement in Adults with Community-Acquired Pneumonia

Astarini,

Aphridasari,

Setijadi

2024

J Respirol Indones

View full text Add to dashboard Cite

Background: Acute lung parenchymal infection, known as pneumonia, can be carried on by multiple microorganisms, including bacteria, viruses, fungi, and parasites. Globally, community-acquired pneumonia is a major factor of morbidity, mortality, and health issues. Malondialdehyde (MDA) is a marker of oxidative stress in pneumonia patients, and interleukin 6 (IL-6) is a marker of inflammatory process. Effect of Omega-3 as an immunomodulator, anti-inflammatory, and antioxidant may be implemented as adjunctive therapy in patient with community-acquired pneumonia.Methods: Clinical trial research with a true experimental method and pretest-posttest design. The study involved 30 community-acquired pneumonia patients who were admitted at Moewardi Hospital in Surakarta and Dr. Soehadi Prijonegoro Hospital in Sragen from August to September 2022 by consecutive sampling. The control group (n=15) received standard therapy, and the treatment group (n=15) received standard therapy plus Omega-3 at a dose of 1600 mg/day. IL-6 and MDA levels were measured when the subject was admitted to the hospital and there was clinical improvement.Results: There was a significant difference in reduced IL-6 levels (P=0.001), decreased MDA levels (P=0.001), and the duration of clinical improvement (P=0.042) between the treatment group and the control group. There was a moderate correlation between the decrease in IL-6 (R=0.480) and MDA (R=0.459), while the duration of clinical improvement had a strong correlation (R=0.756) in the treatment group.Conclusion: Supplementation of Omega-3 was effective in reducing IL-6, MDA levels, and the duration of clinical improvement in community-acquired pneumonia patients.

show abstract

Section: Original Articlementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Role of Omega-3 on the IL-6 Levels, Malondialdehyde, and Clinical Improvement in Adults with Community-Acquired Pneumonia

Astarini,

Aphridasari,

Setijadi

2024

J Respirol Indones

View full text Add to dashboard Cite

show abstract

“…However, it appears that the potential increase in exposure to oxidative species is likely to be a major driver of the increased per unit mass toxicity in the after period. There are prior studies showing the effects of oxidative stress on the reduction in resistance to infection and the resulting increase in disease (e.g., [50,51]).…”

Section: Changes In Health Outcomesmentioning

confidence: 99%

Changing Emissions Results in Changed PM2.5 Composition and Health Impacts

Hopke

Hidy²

2022

Atmosphere

View full text Add to dashboard Cite

In the period of 2005 to 2016, multiple air pollution control regulations have entered into effect in the United States at both the Federal and state level. In addition, economic changes have also occurred primarily in the electricity generation sector that substantially changed the emissions from this sector. This combination of policy implementations and economics has led to substantial reductions in PM2.5, its major constituents, and source specific PM2.5 concentrations across the New York State, particularly those of sulfate, nitrate, and primary organic carbon. However, secondary organic carbon and spark-ignition vehicular emission contributions have increased. Related studies of changes in health outcomes, the excess rates of emergency department visits and hospitalizations for a variety of cardiovascular and respiratory diseases and respiratory infections have increased per unit mass of PM2.5. It appears that the increased toxicity per unit mass was due to the reduction in low toxicity constituents such that the remaining mass had greater impacts on public health.

show abstract

“…Common viruses causing respiratory infections, such as human respiratory syncytial virus (RSV), influenza (IV), human rhinovirus (HRV), human metapneumovirus (HMPV), parainfluenza, adenoviruses and coronaviruses, usually cause only mild symptoms [ 37 ]. Presence of chronic respiratory diseases, such as asthma, chronic obstructive pulmonary disease, or mucoviscidosis, can influence the disease course by shifting the balance towards increased oxidative stress and reactive oxygen species (ROS) formation [ 38 ].…”

Section: Sars-cov-2 Infection Is Associated With Oxidative Stressmentioning

confidence: 99%

Involvement of Oxidative Stress and the Innate Immune System in SARS-CoV-2 Infection

et al. 2021

View full text Add to dashboard Cite

The emergence of the novel coronavirus in December 2019 in China marked the beginning of a pandemic that impacted healthcare systems and economic life all over the world. The virus primarily targets the respiratory system causing severe acute respiratory syndrome (SARS) in some patients, and therefore received the name of SARS-CoV-2. The pathogen stands out among other coronaviruses by its rapid transmission from human to human, with the majority of infected individuals being asymptomatic or presenting with only minor illness, therefore facilitating the pathogen spread. At the same time, people from the risk groups, such as the elderly, patients suffering from chronic diseases, or obese individuals, have increased chances of developing a severe or even fatal disease. The search for risk factors explaining this phenomenon continues. In this review, we focus on the known mechanisms of SARS-CoV-2 infection affecting the functioning of the immune system and discuss potential risk factors responsible for the severe disease course. Oxidative stress is one of such factors, which plays a prominent role in innate immunity activity, and recent research has revealed its tight involvement in SARS-CoV-2 infection. We discuss these recent findings and the development of excessive inflammation and cytokine storm observed during SARS-CoV-2 infection. Finally, we consider potential use of antioxidant drugs for alleviating the severe symptoms in affected patients.

show abstract

Infectious Lung Diseases and Endogenous Oxidative Stress

Cited by 4 publications

References 80 publications

The Role of Omega-3 on the IL-6 Levels, Malondialdehyde, and Clinical Improvement in Adults with Community-Acquired Pneumonia

The Role of Omega-3 on the IL-6 Levels, Malondialdehyde, and Clinical Improvement in Adults with Community-Acquired Pneumonia

Changing Emissions Results in Changed PM2.5 Composition and Health Impacts

Involvement of Oxidative Stress and the Innate Immune System in SARS-CoV-2 Infection

Contact Info

Product

Resources

About