Infectious mononucleosis complicated by acute haemolytic anaemia with a positive Donath-Landsteiner reaction

Wishart, M. M.; Davey, Matthew G

doi:10.1136/jcp.26.5.332

Cited by 28 publications

(11 citation statements)

References 10 publications

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“…chicken pox was implicated. This picture is similar to that in other reports [4,8,13,16] and Donath-Landsteiner haemolysis secondary to cytomegalovirus [4], measles [14], mea sles immunization [10], mumps [11] and infectious mononucleosis [18] has occurred. Although one authority [8,19] feels that most, if not all, non-syphilitic examples are associated with (often unknown) viral disor ders, non-viral infections, e.g.…”

Section: Relation To Infectionsupporting

confidence: 79%

Autoimmune Haemolysis Associated with Donath-Landsteiner Antibodies

Sokol

Hewitt

Stamps³

1982

Acta Haematol

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The clinical pattern of haemolysis associated with Donath-Landsteiner antibodies has undergone a change over the years. In the current study 13 patients developed the acute form of the disease whilst only 1 presented with the classical picture of chronic paroxysmal cold haemoglobinuria. The acute illness typically occurred in young children with a male predominance of about 2.5:1; 10 patients were less than 5 years old. There.was often a history of a preceding infection, the onset was sudden, prostration, haemoglobinuria and pallor were prominent. The patients were very ill but rapid and complete recovery usually occurred within a few days; however, 1 patient died. Treatment consisted of rest and warmth; in addition blood transfusion was needed in 7 patients. The chronic disease (which was non-syphilitic in origin) followed a benign course, warmth and avoidance of cold being all that were necessary to maintain the patient’s well-being. It is felt that the general term for this disorder should be Donath-Landsteiner haemolysis rather than the traditional paroxysmal cold haemoglobinuria

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Section: Relation To Infectionsupporting

confidence: 79%

Autoimmune Haemolysis Associated with Donath-Landsteiner Antibodies

Sokol

Hewitt

Stamps³

1982

Acta Haematol

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“…A few examples of PCH have, however, been described in which the DL antibody apparently had specificities other than anti-P, eg, those of Weiner et al (1964), Bell et al (1973, and Wishart and Davey (1973). The antibody of Bell et al (1973) was anti-I, and in the other two examples specificity was not established.…”

Section: Discussionmentioning

confidence: 99%

“…We wonder if these were true DL antibodies. It is possible that, in some cases, cold autoagglutinins such as anti-I or anti-i may have been present in addition to a DL antibody, for example, the cases of Stewart and Friedlander (1957), Bell et al (1973), Wishart and Davey (1973), and Djaldetti et al (1975).…”

Section: Discussionmentioning

confidence: 99%

“…The cases of Stewart andFriedlander (1957) andBell et al (1973) were associated with primary atypical pneumonia (Mycoplasma pneumoniae infection) in which anti-I is usually present, and the case of Wishart and Davey (1973) was associated with infectious mononucleosis in which anti-i is often present. The antibodies in all three of these cases were strongly haemagglutinating.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Idiopathic non-syphilitic paroxysmal cold haemoglobinuria in children.

Bird¹,

Wingham²,

Martin³

et al. 1976

J Clin Pathol

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Three examples of non-syphilitic paroxysmal cold haemoglobinuria (PCH) in children are described which occurred, within a period of 16 days, in association with a febrile illness. No definite viral aetiology or obvious epidemiological association could be established. A Donath-Landsteiner antibody of anti-P specificity was demonstrated in all three patients. The serological aspects of PCH are critically discussed.

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“…Other autoantibodies that have been associated with AIHA in 1M include anti-N, anti-I, and the Donath-Landsteiner antibody (Bowman et al 1974;Woodruff and McPherson 1976;Wishart and Davey 1973). In addition, the RBC Lewis type and secretor status were examined in a group of patients with AIHA-complicating 1M.…”

Section: Anemiamentioning

confidence: 99%

Infectious Mononucleosis

1989

Clinical Topics in Infectious Disease

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Infectious mononucleosis is a clinical entity characterized by pharyngitis, cervical lymph node enlargement, fatigue and fever, which results most often from a primary Epstein-Barr virus (EBV) infection. EBV, a lymphocrytovirus and a member of the γ-herpesvirus family, infects at least 90% of the population worldwide, the majority of whom have no recognizable illness. The virus is spread by intimate oral contact among adolescents, but how preadolescents acquire the virus is not known. During the incubation period of approximately 6 weeks, viral replication first occurs in the oropharynx followed by viremia as early as 2 weeks before onset of illness. The acute illness is marked by high viral loads in both the oral cavity and blood accompanied by the production of immunoglobulin M antibodies against EBV viral capsid antigen and an extraordinary expansion of CD8 + T lymphocytes directed against EBV-infected B cells. During convalescence, CD8 + T cells return to normal levels and antibodies develop against EBV nuclear antigen-1. A typical clinical picture in an adolescent or young adult with a positive heterophile test is usually sufficient to make the diagnosis of infectious mononucleosis, but heterophile antibodies are not specific and do not develop in some patients especially young children. EBV-specific antibody profiles are the best choice for staging EBV infection. In addition to causing acute illness, long-term consequences are linked to infectious mononucleosis, especially Hodgkin lymphoma and multiple sclerosis. There is no licensed vaccine for prevention and no specific approved treatment. Future research goals are development of an EBV vaccine, understanding the risk factors for severity of the acute illness and likelihood of developing cancer or autoimmune diseases, and discovering anti-EBV drugs to treat infectious mononucleosis and other EBV-spurred diseases.

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Infectious mononucleosis complicated by acute haemolytic anaemia with a positive Donath-Landsteiner reaction

Cited by 28 publications

References 10 publications

Autoimmune Haemolysis Associated with Donath-Landsteiner Antibodies

Autoimmune Haemolysis Associated with Donath-Landsteiner Antibodies

Idiopathic non-syphilitic paroxysmal cold haemoglobinuria in children.

Infectious Mononucleosis

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