Infectious Triggers of Cytokine Storm Syndromes: Herpes Virus Family (Non-EBV)

Dulek, Daniel E.; Thomsen, Isaac

doi:10.1007/978-3-030-22094-5_14

Cited by 1 publication

(1 citation statement)

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“…They also regulate the maturation, the growth, and the functional activities of particular cell populations (T cells, B cells, and myeloid cells) [ 22 , 23 ]. Of note, infectious pathologies due to viruses were known to induce sometimes “cytokine storm,” in severe cases leading to irreversible damages as described for influenza, Ebola, or HCoV virus infection complications [ 24 – 26 ] and even as consequence of herpesviruses infections in some cases [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-adhesion and Anti-inflammatory Potential of the Leaderless Class IIb Bacteriocin Enterocin DD14

Teiar

Pérez-Ramos

Zgheib

et al. 2022

Probiotics & Antimicro. Prot.

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In this study, we investigate the interactions between the leaderless class IIb bacteriocin, enterocin DD14 (EntDD14), or the methicillin or the combination of these antibacterials, and two methicillin-resistant Staphylococcus aureus strains (MRSA-S1 and USA 300) which are respectively a clinical strain and a reference strain. The results obtained showed that EntDD14 alone or in combination with the antibiotic could significantly prevent the adhesion of these pathogenic bacteria to human cells. On the other hand, we investigated the anti-inflammatory effect of EntDD14 on the secretion of pro-inflammatory interleukins, including IL-6 and IL-8. The results show that EntDD14 is able to decrease significantly the secretion of both interleukins on Caco-2 cells following their treatments with lipopolysaccharides. These novel data provide insightful informations to support applications of bacteriocins as therapeutic agents capable as well to defeat pathogenic bacteria and concomitantly limit their inflammatory reactions.

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Section: Introductionmentioning

confidence: 99%