Infective Endocarditis Caused by Staphylococcus aureus After Transcatheter Aortic Valve Replacement

Abdel‐Wahab, Mohamed; Durand, Éric; Ihlemann, Nikolaj; Ureña, Marina; Pellegrini, Costanza; Giannini, Francesco; Gąsior, Tomasz; Wojakowski, Wojtek; Landt, Martin; Auffret, Vincent; Sinning, Jan Malte; Cheema, Asim N.; Nombela‐Franco, Luis; Chamandi, Chekrallah; Campelo‐Parada, Francisco; Muñoz-García, Érika; Herrmann, Howard C.; Testa, Luca; Kim, Won-Keun; Castillo, Juan Carlos; Alperi, Alberto; Tchétché, Didier; Bartorelli, Antonio L.; Kapadia, Samir; Stortecky, Stefan; Amat‐Santos, Ignacio J.; Wijeysundera, Harindra C.; Lisko, John; Gutiérrez‐Ibañes, Enrique; Serra, Violeta; Salido, Luisa; Alkhodair, Abdullah; Vendramin, Igor; Chakravarty, Tarun; Vilalta, Victòria; Regueiro, Ander; Romaguera, Rafael; Kappert, Utz; Barbanti, Marco; Masson, Jean‐Bernard; Maes, Frédéric; Fiorina, Claudia; Miceli, Antonio; Kodali, Susheel; Ribeiro, Henrique Barbosa; Mangione, José Armando; Brito, Fábio Sândoli de; Dato, G. M. Actis; Rosato, Francesco; Ferreira, Maria-Cristina; Lima, Valter Corriea de; Colafranceschi, Alexandre Siciliano; Abizaid, Alexandre; Mariño, Marcos Antonio Maynar; Esteves, Vinícius; Andrea, Júlio; Godinho, Roger R.; Alfonso, Fernándo; Eltchaninoff, Hélène; Søndergaard, Lars; Himbert, Dominique; Hüsser, Oliver; Latib, Azeem; Breton, Hervé; Servoz, Clément; Pascual, Isaac; Siddiqui, Saif; Olivares, Paolo; Hernández‐Antolín, Rosana; Webb, John G.; Sponga, Sandro; Makkar, Raj; Kini, Annapoorna; Boukhris, Marouane; Gervais, Philippe; Linke, Axel; Crusius, Lisa; Holzhey, David; Rodés‐Cabau, Josep

doi:10.1016/j.cjca.2021.10.004

Cited by 17 publications

(25 citation statements)

References 28 publications

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“…The series presented in this article is the largest published to date, with SAPVE cases accounted for 16.7% of all cases of PVE. This percentage was lower than that found in series of PVE [9], [11], but similar to those of other studies [3], [7]. Another characteristic of our patients was the high proportion of cases diagnosed during the rst year after valve implantation, as previously reported [21].…”

Section: Comparison Of Sapve With Those Caused By Other Microorganismssupporting

confidence: 88%

“…[8], [9], [10], [11], [25]. Despite the higher clinical severity, fewer patients with SAPVE were treated surgically compared to patients with PVE caused by other microorganisms [3] caused by MRSA was 21% in our study, which is within the range of other published series (6-41%) [3], [6], [9], [11], [26], [27]. Differences in the characteristics of the patients studied and the time in which the studies were performed may account for the observed variability.…”

Section: Comparison Of Sapve With Those Caused By Other Microorganismsmentioning

confidence: 99%

“…Heart failure is a very frequent complication in patients with SAPVE [3], [7], [10], [29], with an incidence higher than that found in patients with PVE due to other microorganisms [11]. This complication is usually due to extensive valve damage and is the most frequent cause of both surgical indication and the patient's own death [3], [9], [26].…”

Section: Comparison Of Sapve With Those Caused By Other Microorganismsmentioning

confidence: 99%

“…This severity is clinically manifested by a higher frequency of septic shock, persistent bacteremia, stroke, and perivalvular abscess, among other complications. [2], [7], [9], [10], [11].…”

Section: Introductionmentioning

confidence: 99%

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Clinical features and prognosis of prosthetic valve endocarditis due to Staphylococcus aureus

Calderón-Parra,

Ramos-Martínez,

Muñoz

et al. 2024

Preprint

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Purpose. Staphylococcus aureus prosthetic valve endocarditis (SAPVE) is a serious infection with high mortality. The main objective of this study was to identify factors associated with in-hospital mortality. Methods. From January 2008 to December 2021, consecutive patients from a Spanish cohort of infective endocarditis with a definitive diagnosis of SAPVE were analyzed. Results. During the study period, 219 cases of definitive SAPVE were diagnosed, which accounted for 16.7% of a total of 1309 cases of definitive prosthetic valve endocarditis (PVE). Patients presented advanced age and marked comorbidity. There was a higher incidence of persistent bacteremia, septic shock, stroke, and acute kidney injury than in cases of PVE caused by other microorganisms. Methicillin resistance was not associated with differences in clinical presentation, echocardiographic findings, or mortality. Only 50.6% of the patients with surgical indications (88 patients) underwent surgery. Overall, in-hospital mortality was 47.9%. The variables associated with in-hospital mortality were age (OR:1.03, 95% CI: 1.00-1.05; p = 0.016), heart failure (OR:2.86, 95% CI: 1.53–5.32; p = 0.001), acute kidney injury (OR:2.42, 95%CI:1.28–4.58; p = 0.006), stroke (OR:3.53, 95%CI:1.79–6.96; p < 0.001) and surgery indicated but not performed (OR:2.01, 95%CI:1.06–3.8; p = 0.030). On the other hand, the performance of surgery per se in patients with SAPVE, regardless of whether there was a surgical indication according to the guidelines, was not associated with a reduction in in-hospital mortality. Conclusions. SAPVE is characterized by high mortality, which is more marked in patients who present a surgical indication but do not undergo surgery.

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Section: Comparison Of Sapve With Those Caused By Other Microorganismssupporting

confidence: 88%

Section: Comparison Of Sapve With Those Caused By Other Microorganismsmentioning

confidence: 99%

Section: Comparison Of Sapve With Those Caused By Other Microorganismsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical features and prognosis of prosthetic valve endocarditis due to Staphylococcus aureus

Calderón-Parra,

Ramos-Martínez,

Muñoz

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…9,10,13 Likewise, surgical treatment does not seem to improve outcome in infective endocarditis after transcatheter aortic valve replacement complicated by stroke. 54 The persistent uncertainties about the optimal timing of surgery in infective endocarditis reflect the need for adequately designed clinical studies, ideally as a randomized controlled trial. However, to achieve a completed enrollment of the respective population of any meaningful study size is extremely challenging, which is also reflected by the scarcity of merely seven randomized controlled trials on infective endocarditis in the last 20 yr, most of which focused on antibiotic therapy.…”

Section: Anesthesia and Infective Endocarditismentioning

confidence: 99%

Anesthesia Considerations in Infective Endocarditis

et al. 2022

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The management of infective endocarditis is complex and inherently requires multidisciplinary cooperation. About half of all patients diagnosed with infective endocarditis will meet the criteria to undergo cardiac surgery, which regularly takes place in urgent or emergency settings. The pathophysiology and clinical presentation of infective endocarditis make it a unique disorder within cardiac surgery that warrants a thorough understanding of specific characteristics in the perioperative period. This includes, among others, echocardiography, coagulation, bleeding management, or treatment of organ dysfunction. In this narrative review article, the authors summarize the current knowledge on infective endocarditis relevant for the clinical anesthesiologist in perioperative management of respective patients. Furthermore, the authors advocate for the anesthesiologist to become a structural member of the endocarditis team.

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Clinical features and prognosis of prosthetic valve endocarditis due to Staphylococcus aureus

Diego-Yagüe,

Ramos-Martínez,

Muñoz

et al. 2024

Eur J Clin Microbiol Infect Dis

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Purpose Staphylococcus aureus prosthetic valve endocarditis (SAPVE) is a serious infection with high mortality. The main objective of this study was to identify factors associated with in-hospital mortality. Methods From January 2008 to December 2021, consecutive patients from a Spanish cohort of infective endocarditis with a definitive diagnosis of SAPVE were analyzed. Results During the study period, 219 cases of definitive SAPVE were diagnosed, which accounted for 16.7% of a total of 1309 cases of definitive prosthetic valve endocarditis (PVE). Patients presented advanced age and marked comorbidity. There was a higher incidence of persistent bacteremia, septic shock, stroke, and acute kidney injury than in cases of PVE caused by other microorganisms. Methicillin resistance was not associated with differences in clinical presentation, echocardiographic findings, or mortality. Only 50.6% of the patients with surgical indications (88 patients) underwent surgery. Overall, in-hospital mortality was 47.9%. The variables associated with in-hospital mortality were age (OR:1.03, 95% CI: 1.00-1.05; p = 0.016), heart failure (OR:2.86, 95% CI: 1.53–5.32; p = 0.001), acute kidney injury (OR:2.42, 95%CI:1.28–4.58; p = 0.006), stroke (OR:3.53, 95%CI:1.79–6.96; p < 0.001) and surgery indicated but not performed (OR:2.01, 95%CI:1.06–3.8; p = 0.030). On the other hand, the performance of surgery per se in patients with SAPVE, regardless of whether there was a surgical indication according to the guidelines, was not associated with a reduction in in-hospital mortality. Conclusions SAPVE is characterized by high mortality, which is more marked in patients who present a surgical indication but do not undergo surgery.

show abstract

Infective Endocarditis Caused by Staphylococcus aureus After Transcatheter Aortic Valve Replacement

Cited by 17 publications

References 28 publications

Clinical features and prognosis of prosthetic valve endocarditis due to Staphylococcus aureus

Clinical features and prognosis of prosthetic valve endocarditis due to Staphylococcus aureus

Anesthesia Considerations in Infective Endocarditis

Clinical features and prognosis of prosthetic valve endocarditis due to Staphylococcus aureus

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