2017
DOI: 10.1055/s-0042-109659
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Infektiologische Differenzialdiagnosen bei granulomatösen Lungenerkrankungen

Abstract: Infections are the most common cause of granulomatous lung diseases. A variety of different pathogens can cause granuloma formation. The diagnosis requires consideration of endemic characteristics, patients' predispositions as well as specific requirements for pathogen detection. The aim of this review is to give a short overview of the most important causative pathogens and facilitate the differential diagnostic approach of granulomatous lung diseases.

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Cited by 2 publications
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“…These agents can be categorized into bacterial (tuberculosis, leprae, salmonella, brucella, syphilis, Q fever, cat scratch disease), chlamydial (lymphogranuloma venereum), fungal (histoplasmosis, blastomycosis, coccidiomycosis), helminthic (schistosomiasis, filariasis, trichinosis) infections, metals (berylliosis, zirconium), organic salts, foreign bodies (silicosis, asbestosis), and etiologically unknown diseases (sarcoidosis, Crohn's disease, Wegener's granulomatosis, primary biliary cirrhosis). The most common granulomatous disease in Turkey and in developing countries is mycobacterial infection-related tuberculosis [2,3]. The presence of a large number of macrophages and lymphocytes in granulomatous diseases is associated with high uptake of 18F-fluoro-2-deoxy-d-glucose (FDG) mimicking lung cancer on PET imaging [3,4].…”
Section: Discussionmentioning
confidence: 99%
“…These agents can be categorized into bacterial (tuberculosis, leprae, salmonella, brucella, syphilis, Q fever, cat scratch disease), chlamydial (lymphogranuloma venereum), fungal (histoplasmosis, blastomycosis, coccidiomycosis), helminthic (schistosomiasis, filariasis, trichinosis) infections, metals (berylliosis, zirconium), organic salts, foreign bodies (silicosis, asbestosis), and etiologically unknown diseases (sarcoidosis, Crohn's disease, Wegener's granulomatosis, primary biliary cirrhosis). The most common granulomatous disease in Turkey and in developing countries is mycobacterial infection-related tuberculosis [2,3]. The presence of a large number of macrophages and lymphocytes in granulomatous diseases is associated with high uptake of 18F-fluoro-2-deoxy-d-glucose (FDG) mimicking lung cancer on PET imaging [3,4].…”
Section: Discussionmentioning
confidence: 99%
“…Bei der Verdachtsdiagnose einer Sarkoidose auf Basis des erhöhten CD4/CD8-Quotienten sollte bedacht werden, dass der erhöhte Quotient in der bronchoalveolären Lavage lediglich als Hinweis, nicht aber als sicherer Nachweis einer Sarkoidose zu werten ist [12]. Auch sollten bei Nachweis von nichtnekrotisierenden Granulomen die Differenzialdiagnosen ausgeschlossen werden [13]. So sollte neben der Sarkoidose und Tuberkulose auch an eine mögliche Berylliose bei entsprechender Arbeitsanamnese oder an oben genannte Infektionserkrankungen gedacht werden.…”
Section: Diskussionunclassified