“…Signs of regional catheter-associated infections were graded according to the predefined criteria [ 2 , 3 , 8 , 9 ] as mild (reddishness, swelling, and painful palpation, ≥2 positive criteria), intermediate (systemic signs of inflammation, e.g., CRP, leukocytosis, fever, and need for antibiotic treatment; ≥2 criteria must be fulfilled), or severe infection (surgical intervention needed).…”