Inferior alveolar nerve allogenic repair following mandibulectomy: A systematic review

Donne, Mélanie Le; Jouan, Robin; Bourlet, Jérôme; Louvrier, Aurélien; Ducret, Maxime; Sigaux, N.

doi:10.1016/j.jormas.2021.04.007

Cited by 6 publications

(4 citation statements)

References 36 publications

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“…24,25 Damage to the inferior alveolar nerve can result in symptoms of oral incompetence, such as drooling or issues with feeding, due to loss of sensory feedback in the lower lip. [24][25][26][27] Multiple studies have shown that mental nerve reconstruction was successful in restoring sensation after segmental mandibulectomy, leading to improved functional outcomes with reduced drooling and improved oral competency in adults. [24][25][26] In one of our mandibulectomy patients, the right inferior alveolar and mental nerve were repaired using an interposition nerve allograft at the time of reconstruction.…”

Section: Discussionmentioning

confidence: 99%

“…[24][25][26][27] Multiple studies have shown that mental nerve reconstruction was successful in restoring sensation after segmental mandibulectomy, leading to improved functional outcomes with reduced drooling and improved oral competency in adults. [24][25][26] In one of our mandibulectomy patients, the right inferior alveolar and mental nerve were repaired using an interposition nerve allograft at the time of reconstruction. One year postoperatively, the patient did not endorse complaints of numbness or pain in the inferior alveolar/mental nerve distribution, and had resumed normal speech, mastication, and swallowing function.…”

Section: Discussionmentioning

confidence: 99%

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Pediatric Maxilla-Mandible Oncoplastic Reconstruction: A 25 Patient Case Series

Burns,

Yim,

Hashemi

et al. 2023

FACE

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Objective: We present a case series of 25 pediatric patients who underwent maxillary and mandibular oncoplastic reconstruction at a single institution. Further, we discussed the present review of the literature and underscored the unique considerations for the pediatric population. Methods: A retrospective chart review of 25 pediatric oncoplastic patients undergoing maxillary and/or mandibular reconstruction was performed from March 2015 to January 2022. Results: Thirteen patients underwent maxillary reconstruction, and 12 patients underwent mandibular reconstruction. The mean age of the maxillary cohort was 10.2 years, and the mean age of the mandibular cohort was 9.8 years. The age range of patients followed was from 6 months to 18.8 years. All patients displayed satisfactory postoperative swallowing and facial symmetry at subsequent follow-up visits. Conclusion: Maxillary and mandibular reconstruction following oncologic resection requires special attention in the pediatric population because of the difficulty to predict bony growth of the mid and lower face, and the resultant effects on dentition and symmetry. Our case series demonstrates successful pediatric maxillomandibular reconstruction utilizing microvascular free tissue transfer and 3D virtual surgical planning.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pediatric Maxilla-Mandible Oncoplastic Reconstruction: A 25 Patient Case Series

Burns,

Yim,

Hashemi

et al. 2023

FACE

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“…The processed nerve allograft (PNA) is a promising option for IAN reconstruction, since unlike the autograft (considered the gold standard), has greater advantages in terms of morbidity, biocompatibility, convenience of use and supply abundance ( 29 ). Currently, Avance Nerve Graft (Axogen Inc, Alachua, FL) is the only PNA available in the market ( 30 ). This PNA consists of an extracellular matrix scaffold created from donated human peripheral nerve tissue that has been predegenerated, decellularized and sterilized ( 1 ).…”

Section: Discussionmentioning

confidence: 99%

Decellularized allografts as an alternative for reconstruction of large inferior alveolar nerve defects: a systematic review

Matus

Aravena²,

Mariño³

et al. 2023

Med Oral

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Background Inferior alveolar nerve (IAN) injuries are a clinical problem with devastating consequences, causing temporary or permanent paresthesia, significantly affecting the patient's quality of life. Despite morbidity, side effects and controversy regarding its results, autologous nerve grafting is still the main treatment for these type of lesions. However, due to advances in knowledge about nerve damage and with the aim of preventing the described problems of autografts, new treatment alternatives based on decellularized allografts have emerged. The aim of this systematic review was to evaluate the reported efficacy of decellularized allografts for the treatment of IAN damage. Material and Methods We performed a systematic search in Pubmed, Scopus and Web of Science databases following the PRISMA guidelines. Cohort studies, randomized or non-randomized clinical studies, prospective or retrospective studies, without age limits and language restriction that included human subjects who received decellularized allograft as treatment for IAN damage were included. Results Six articles met the inclusion criteria and were included for data analysis. In all 6 articles, resolution of IAN damage was observed in more than 85% of patients after a 12-month follow-up period, and in 2 of them, complete resolution was observed in 100% of their patients at longer follow-ups. Conclusions Decellularized allograft appears to be a promising alternative to resolve IAN lesions, without requiring a nerve autograft procedure. However, more randomized clinical trials are needed to validate adequate treatment modalities with decellularized allografts. Key words: Decellularized allograft, alveolar inferior nerve, allograft, injury.

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“…To mitigate donor-side morbidity, there is ongoing research on processed-decellularized allografts [ 47 ]. These allografts demonstrate high success rates, exceeding 85%, in achieving sensory restoration for both smaller and larger defects (documented in the literature for defects up to 7 cm [ 61 ]), albeit in limited patient numbers thus far [ 48 , 61 , 64 ]. In addition to autologous and allogeneic grafts, various alloplastic or xenogeneic scaffolds are available, which can be either resorbable or non-resorbable.…”

Section: Treatment Of Traumatic Nerve Injurymentioning

confidence: 99%

Clinical insights into traumatic injury of the inferior alveolar and lingual nerves: a comprehensive approach from diagnosis to therapeutic interventions

Kämmerer,

Heimes,

Hartmann

et al. 2024

Clin Oral Invest

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Objectives This scoping review explores the risk and management of traumatic injuries to the inferior alveolar and lingual nerves during mandibular dental procedures. Emphasizing the significance of diagnostic tools, the review amalgamates existing knowledge to offer a comprehensive overview. Materials and methods A literature search across PubMed, Embase, and Cochrane Library informed the analysis. Results Traumatic injuries often lead to hypo-/anesthesia and neuropathic pain, impacting individuals psychologically and socially. Diagnosis involves thorough anamnesis, clinical-neurological evaluations, and radiographic imaging. Severity varies, allowing for conservative or surgical interventions. Immediate action is recommended for reversible causes, while surgical therapies like decompression, readaptation, or reconstruction yield favorable outcomes. Conservative management, utilizing topical anesthesia, capsaicin, and systemic medications (tricyclic antidepressants, antipsychotics, and serotonin-norepinephrine-reuptake-inhibitors), proves effective for neuropathic pain. Conclusions Traumatic nerve injuries, though common in dental surgery, often go unrecorded. Despite lacking a definitive diagnostic gold standard, a meticulous examination of the injury and subsequent impairments is crucial. Clinical relevance Tailoring treatment to each case's characteristics is essential, recognizing the absence of a universal solution. This approach aims to optimize outcomes, restore functionality, and improve the quality of life for affected individuals. Graphical abstract

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Inferior alveolar nerve allogenic repair following mandibulectomy: A systematic review

Cited by 6 publications

References 36 publications

Pediatric Maxilla-Mandible Oncoplastic Reconstruction: A 25 Patient Case Series

Pediatric Maxilla-Mandible Oncoplastic Reconstruction: A 25 Patient Case Series

Decellularized allografts as an alternative for reconstruction of large inferior alveolar nerve defects: a systematic review

Clinical insights into traumatic injury of the inferior alveolar and lingual nerves: a comprehensive approach from diagnosis to therapeutic interventions

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