Inferior Olive Response to Passive Tactile and Visual Stimulation with Variable Interstimulus Intervals

Wu, Xi; Nestrašil, Igor; Ashe, James; Tuite, Paul J.; Bushara, Khalafalla O.

doi:10.1007/s12311-010-0203-8

Cited by 15 publications

(15 citation statements)

References 33 publications

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“…Our results highlight the specific functional role of several areas, including the putamen and caudate, the temporal cortex, and primarily the cerebellum, an area previously commonly associated with temporal tasks, although probably of an underspecified level of contribution [ 11 ]. Our finding of high activation in the cerebellum associated with increasing speed, and hence also with the difficulty of the task, is well in accordance with previous studies of subsecond spectrum retrospective temporal processing utilizing transcranial magnetic stimulation of the cerebellum [ 39 – 41 ] and imaging methods [ 25 , 42 – 46 ], and also with the hypothesis that this neural node acts as a timing system for brief intervals [ 47 ]. Even if reported as the most commonly engaged structure in retrospective subsecond temporal computing [ 5 ], the extent of the volume of activated cerebellar tissue and the dominance of the cerebellar cluster in the current study far exceeds the volumes and the rank among the other neural nodes reported in retrospective timing tasks [ 3 ].…”

Section: Discussionsupporting

confidence: 92%

Neural Network of Predictive Motor Timing in the Context of Gender Differences

et al. 2016

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Time perception is an essential part of our everyday lives, in both the prospective and the retrospective domains. However, our knowledge of temporal processing is mainly limited to the networks responsible for comparing or maintaining specific intervals or frequencies. In the presented fMRI study, we sought to characterize the neural nodes engaged specifically in predictive temporal analysis, the estimation of the future position of an object with varying movement parameters, and the contingent neuroanatomical signature of differences in behavioral performance between genders. The established dominant cerebellar engagement offers novel evidence in favor of a pivotal role of this structure in predictive short-term timing, overshadowing the basal ganglia reported together with the frontal cortex as dominant in retrospective temporal processing in the subsecond spectrum. Furthermore, we discovered lower performance in this task and massively increased cerebellar activity in women compared to men, indicative of strategy differences between the genders. This promotes the view that predictive temporal computing utilizes comparable structures in the retrospective timing processes, but with a definite dominance of the cerebellum.

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Section: Discussionsupporting

confidence: 92%

Neural Network of Predictive Motor Timing in the Context of Gender Differences

et al. 2016

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“…Moreover, it was markedly larger following a violation, consistent with the idea that the cerebellum was sensitive to temporal prediction violations. Further support for this idea comes from fMRI work showing larger cerebellar activation to visual stimuli with unpredictable timing (e.g., [ 161 ]) as well as a study in which an early ERP signal to deviant auditory stimuli was found to be abnormal in patients with cerebellar degeneration [ 162 ].…”

Section: Sensory Processing and The Cerebellum: Timing (Rb Ivry)mentioning

confidence: 99%

Consensus Paper: The Role of the Cerebellum in Perceptual Processes

Baumann

Borra

Bower³

et al. 2014

Cerebellum

392

306

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Various lines of evidence accumulated over the past 30 years indicate that the cerebellum, long recognized as essential for motor control, also has considerable influence on perceptual processes. In this paper, we bring together experts from psychology and neuroscience, with the aim of providing a succinct but comprehensive overview of key findings related to the involvement of the cerebellum in sensory perception. The contributions cover such topics as anatomical and functional connectivity, evolutionary and comparative perspectives, visual and auditory processing, biological motion perception, nociception, self-motion, timing, predictive processing, and perceptual sequencing. While no single explanation has yet emerged concerning the role of the cerebellum in perceptual processes, this consensus paper summarizes the impressive empirical evidence on this problem and highlights diversities as well as commonalities between existing hypotheses. In addition to work with healthy individuals and patients with cerebellar disorders, it is also apparent that several neurological conditions in which perceptual disturbances occur, including autism and schizophrenia, are associated with cerebellar pathology. A better understanding of the involvement of the cerebellum in perceptual processes will thus likely be important for identifying and treating perceptual deficits that may at present go unnoticed and untreated. This paper provides a useful framework for further debate and empirical investigations into the influence of the cerebellum on sensory perception.

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“…Other studies revealed that the IO is involved in the cognitive property of perception of temporal complex rhythmic stimuli (Xu et al, 2006; Liu et al, 2008; Wu et al, 2010). The impact of mefloquine on the IO and on the olivocerebellar dependent behaviors has never been investigated in humans.…”

Section: Introductionmentioning

confidence: 97%

Anti-Malaria Drug Mefloquine Induces Motor Learning Deficits in Humans

Essen¹,

Giessen²,

Koekkoek³

et al. 2010

Front. Neurosci.

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Mefloquine (a marketed anti-malaria drug) prophylaxis has a high risk of causing adverse events. Interestingly, animal studies have shown that mefloquine imposes a major deficit in motor learning skills by affecting the connexin 36 gap junctions of the inferior olive. We were therefore interested in assessing whether mefloquine might induce similar effects in humans. The main aim of this study was to investigate the effect of mefloquine on olivary-related motor performance and motor learning tasks in humans. We subjected nine participants to voluntary motor timing (dart throwing task), perceptual timing (rhythm perceptual task) and reflex timing tasks (eye-blink task) before and 24 h after the intake of mefloquine. The influence of mefloquine on motor learning was assessed by subjecting participants with and without mefloquine intake (controls: n = 11 vs mefloquine: n = 8) to an eye-blink conditioning task. Voluntary motor performance, perceptual timing, and reflex blinking were not affected by mefloquine use. However, the influence of mefloquine on motor learning was substantial; both learning speed as well as learning capacity was impaired by mefloquine use. Our data suggest that mefloquine disturbs motor learning skills. This adverse effect can have clinical as well as social clinical implications for mefloquine users. Therefore, this side-effect of mefloquine should be further investigated and recognized by clinicians.

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Inferior Olive Response to Passive Tactile and Visual Stimulation with Variable Interstimulus Intervals

Cited by 15 publications

References 33 publications

Neural Network of Predictive Motor Timing in the Context of Gender Differences

Neural Network of Predictive Motor Timing in the Context of Gender Differences

Consensus Paper: The Role of the Cerebellum in Perceptual Processes

Anti-Malaria Drug Mefloquine Induces Motor Learning Deficits in Humans

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