This study focuses on the psychological consequences of infertility, using Bowen's Systematic Family Therapy as a conceptual framework. Infertility is often characterized as a profound and intricate life challenge that profoundly affects an individual's emotional health. Research has underscored the psychological ramifications linked to this condition, including feelings of grief, heightened anxiety, depression, and diminished self-worth. Historically, early research linked infertility to psychological defenses against pregnancy, but advancements in medical technology have since refuted the psychogenic hypothesis, emphasizing biomedical factors. Nevertheless, the psychological ramifications remain substantial, necessitating a nuanced approach to therapy. Bowen's Systematic Family Therapy offers valuable insights through its eight key concepts, including differentiation of self, family projection process, and multigenerational transmission. These concepts help in understanding the intricate emotional dynamics and stress patterns within the family unit affected by infertility. Studies suggest that family therapy can mitigate emotional distress, improve marital satisfaction, and facilitate communication among family members. Despite the limited direct research on Bowen's Systematic Family Therapy and infertility, existing literature underscores the importance of integrated therapeutic approaches that consider emotional and relational contexts. Future research should focus on expanding the application of family therapy models in infertility treatment, developing comprehensive support mechanisms, and addressing the psychological needs of both individuals and their extended families. This holistic perspective is essential for fostering resilience and emotional well-being in families facing infertility.