Infertility in Mice Exposed in utero to Benzo(a)pyrene1

MacKenzie, K.M.; Angevine, D. Murray

doi:10.1095/biolreprod24.1.183

Cited by 191 publications

(113 citation statements)

References 18 publications

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“…As conseqüências do tabagismo dos pais sobre a fertilidade da prole feminina foram sugeridas por estudos animais. A exposição prévia de fêmeas de camundongos ao benzopireno, um componente do cigarro, resultou posteriormente em prejuízo da fertilidade, o que poderia estar relacionado à destruição de oócitos primários 16 . Estudando a exposição intra-uterina ao cigarro, por inquérito retrospectivo com mulheres na Carolina do Norte, EUA, Weimberg, Wilcox e Baird 17 observaram, na vida adulta, redução na fertilidade de até 50% (taxa de fecundabilidade = 0,5 95% IC 0,4-0,8).…”

Section: Tabagismo E Fertilidadeunclassified

Influência do tabagismo na fertilidade, gestação e lactação

Mello¹,

Pinto²,

Botelho³

2001

J. Pediatr. (Rio J.)

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Objective: to decribe the influence of smoking on different phases of the reproductive process, fecundation, pregnancy and lactation, drawing special attention to the mechanisms of action of the main toxic components found in cigarettes. To suggest prophylactic measures for environmental control and how to reduce children's exposure to tobacco smoke.Methods: nonsystematic literature review using MEDLINE database.Results: smoking has a negative effect on different phases of the reproduction process, by direct action of main toxic components, nicotine and carbon monoxide. Smoking reduces fertility, compromises the length of gestation and infant birthweight. Smoking mothers also have reduced breast milk production and shorter lactation, which affects infant weight gain through unclear mechanisms in which prolactin may probably be involved.Conclusions: smoking compromises reproductive function quality in different phases, acting mainly on intrauterine and extrauterine development of infants. Since during pregnancy and lactation women are in closer contact with health professionals, antismoking campaigns should be especially addressed to this period.J Pediatr (Rio J) 2001; 77 (4): 257-64: smoking, fertility, pregnancy, lactation, breast feeding. ResumoObjetivo: descrever a influência do tabagismo nas diferentes fases do processo reprodutivo, fecundação, gestação e lactação, destacando os mecanismos de ação dos principais componentes tóxicos do cigarro nestas fases. Sugerir medidas profiláticas de controle ambiental e de como reduzir a exposição da criança à fumaça do tabaco.Métodos: revisão bibliográfica não sistemática sobre os temas abordados, utilizando-se da base de dados do MEDLINE.Resultados: o tabagismo atua negativamente nas diferentes fases da reprodução, por ação direta de seus principais componentes tóxicos, a nicotina e o monóxido de carbono. Reduz a taxa de fertilidade, compromete a duração da gestação e o peso do concepto. Também diminui a produção de leite da nutriz fumante e o tempo de lactação, comprometendo o ganho de peso da prole, por mecanismos ainda não bem compreendidos, nos quais a prolactina pode estar envolvida.Conclusões: os efeitos do tabagismo comprometem a qualidade da função reprodutiva em diferentes fases, por atuar principalmente sobre o desenvolvimento do concepto, tanto na fase intra quanto na fase extra-uterino. Por ser um período de contato mais freqüente da mulher fumante com o profissional de saúde, a gestação e a lactação deveriam ser alvo especial de campanhas antitabágicas.J Pediatr (Rio J) 2001; 77 (4): 257-64: tabagismo, fertilidade, gestação, lactação, aleitamento materno. Influência do tabagismo na fertilidade, gestação e lactaçãoThe influence of smoking on fertility, pregnancy and lactation Paulo Roberto Bezerra de Mello 1 , Gilberto Rodrigues Pinto 2 , Clovis Botelho 3A fumaça do cigarro no ambiente é derivada de duas origens: fumaça central (FC) e fumaça periférica (FP). A fumaça central é formada quando o fumante traga o cigarro, é produzida com altas temperat...

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Section: Tabagismo E Fertilidadeunclassified

Influência do tabagismo na fertilidade, gestação e lactação

Mello¹,

Pinto²,

Botelho³

2001

J. Pediatr. (Rio J.)

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“…Benzo [a]pyrene has been shown to impair male and female reproductive performance and to decrease pup weight in laboratory animals exposed by the oral and inhalation routes. Exposure of pregnant female mice to benzo [a]pyrene affected the fertility and the histopathology of the ovaries and testes of their offspring (MacKenzie & Angevine, 1981;Kristensen et al, 1995). No standard developmental or two-generation reproductive studies are available on exposure to benzo [a]pyrene via the oral route, but several studies have evaluated the reproductive effects of in-utero exposure.…”

Section: Reproductive and Developmental Toxicitymentioning

confidence: 99%

Integrating Field Analyses with Laboratory Exposures to Assess Ecosystems Health

Hellou¹,

Beach²,

Leonard³

et al. 2012

Polycyclic Aromatic Compounds

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initiated a programme on the evaluation of the carcinogenic risk of chemicals to humans involving the production of critically evaluated monographs on individual chemicals. The programme was subsequently expanded to include evaluations of carcinogenic risks associated with exposures to complex mixtures, life-style factors and biological and physical agents, as well as those in specific occupations. The objective of the programme is to elaborate and publish in the form of monographs critical reviews of data on carcinogenicity for agents to which humans are known to be exposed and on specific exposure situations; to evaluate these data in terms of human risk with the help of international working groups of experts in chemical carcinogenesis Publications of the World Health Organization enjoy copyright protection in accordance with the provisions of Protocol 2 of the Universal Copyright Convention. All rights reserved.The International Agency for Research on Cancer welcomes requests for permission to reproduce or translate its publications, in part or in full. Requests for permission to reproduce or translate IARC publications -whether for sale or for noncommercial distribution -should be addressed to WHO Press, at the above address (fax: +41 22 791 4806; email: permissions@who.int).The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the World Health Organization concerning the legal status of any country, territory, city, or area or of its authorities, or concerning the delimitation of its frontiers or boundaries.The mention of specific companies or of certain manufacturers' products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.The IARC Monographs Working Group alone is responsible for the views expressed in this publication. IARC Library Cataloguing in Publication Data NOTE TO THE READERThe term 'carcinogenic risk' in the IARC Monographs series is taken to mean that an agent is capable of causing cancer under some circumstances. The Monographs evaluate cancer hazards, despite the historical presence of the word 'risks' in the title.Inclusion of an agent in the Monographs does not imply that it is a carcinogen, only that the published data have been examined. Equally, the fact that an agent has not yet been evaluated in a Monograph does not mean that it is not carcinogenic.The evaluations of carcinogenic risk are made by international working groups of independent scientists and are qualitative in nature. No recommendation is given for regulation or legislation.Anyone who is aware of published data that may alter the evaluation of the carcinogenic risk of an agent to humans is encouraged to make this information available to the Section of IARC Monographs, International Agency for...

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“…In utero exposure to B[a]P has produced adverse reproductive effects in mice (Legraverend, et al, 1984). Dietary administration of doses as low as 10 mg/kg during gestation caused reduced fertility and reproductive capacity in offspring (Mackenzie and Angevine, 1981) and treatment by gavage with 120 mg/kg/day during gestation caused stillbirths and malformations (Legraverend et al, 1984).…”

Section: Effects Of Benzo[a]pyrene On Reproductionmentioning

confidence: 99%

Benzo[a]pyrene and Human Embryo

Shi¹,

Liu²,

Ye³

2012

The Human Embryo

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Infertility in Mice Exposed in utero to Benzo(a)pyrene1

Cited by 191 publications

References 18 publications

Influência do tabagismo na fertilidade, gestação e lactação

Influência do tabagismo na fertilidade, gestação e lactação

Integrating Field Analyses with Laboratory Exposures to Assess Ecosystems Health

Benzo[a]pyrene and Human Embryo

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