Infertility: Prognostic indicators for intrauterine insemination (IUI): statistical model for IUI success

Tomlinson, Mathew; Amissah-Arthur, J.B.; Thompson, Kathleen; Kasraie, Jason; Bentick, Bernard

doi:10.1093/oxfordjournals.humrep.a019513

Cited by 158 publications

(114 citation statements)

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“…The advancing maternal age decreases female fecundity 13 and this is due to reduced uterine receptivity 14 and/ or decreased oocyte quality. However, the prognostic value of woman's age was not significant in studies undertaken by Brzechffa et al 15 and Tomlinson et al 16 which was similar to our study.…”

Section: Koli P Et Al Int J Reprod Contracept Obstet Gynecol 2013 Ssupporting

confidence: 92%

Intrauterine insemination: a retrospective review on determinants of success

Koli

Anıl

Ramya

et al. 2013

Int J Reprod Contracept Obstet Gynecol

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Background: To determine the prognostic factors such as female patient’s characteristics and of semen parameters on the pregnancy rate following intrauterine insemination Methods: This study was done at Assisted Reproduction Centre, KLE’s Hospital and Medical Research Centre, Belgaum, India between June 2011 to May 2012. A total of 264 IUI cycles in which clomiphene citrate with or without human menopausal gonadotropin was used for ovarian stimulation were analysed retrospectively to identify prognostic factors regarding treatment outcome. Results: In this study the pregnancy rate was 17.25%. The logistic regression analysis of variables showed that number of follicles and total IUI cycles were significantly associated with success rate but age of the couple, duration of infertility, endometrial thickness, size of the follicles, sperm count and sperm motility did not show significant differences between pregnant and non pregnant women. Conclusions: The findings of this study showed that age of the couple, duration of infertility, endometrial thickness, size of the follicles, sperm count and sperm motility did not correlate with pregnancy occurrence in an IUI cycle but number of follicles and total IUI cycles correlated with the occurrence of pregnancy. [Int J Reprod Contracept Obstet Gynecol 2013; 2(3.000): 311-314

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Section: Koli P Et Al Int J Reprod Contracept Obstet Gynecol 2013 Ssupporting

confidence: 92%

Intrauterine insemination: a retrospective review on determinants of success

Koli

Anıl

Ramya

et al. 2013

Int J Reprod Contracept Obstet Gynecol

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“…In the present study, we also observed that as the infertility duration became longer, the gestation rates also increased. However, in the literature, many studies have indicated that as the age (5,8,17) and infertility duration (7,17,18) increase, gestational rates decrease. Also, Ibérico et al (19) reported in a study published in 2004 that gestational rates in IUI decreased independently of the age through longer infertility durations.…”

Section: Discussionmentioning

confidence: 99%

Factors affecting clinical pregnancy rates after IUI for the treatment of unexplained infertility and mild male subfertility

Atasever¹,

Kalem²,

Hatırnaz³

et al. 2016

J Turkish German Gynecol Assoc

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Objective:The aim of the present retrospective study was to evaluate intrauterine insemination (IUI) clinical experiences and to define the variables for predicting success. Material and Methods:The present study was an observational trial performed in a private IVF center on subfertile couples who had applied for treatment between 2002 and 2012, in which the data of 503 IUI cases were retrospectively reviewed. Couples who had been diagnosed with unexplained and mild male subfertility were included. The primary outcome measure was the clinical pregnancy rate in an attempt to form a predictive model for the odds of a clinical pregnancy. Recorded parameters were used to determine the prediction model. Results:Utilizing univariate logistic regression analysis, clinical pregnancy was positively associated with the duration of infertility (OR=1.09, p=0.089), secondary infertility (OR=1.77, p=0.050), and +4 sperm motility after preparation (OR=1.03, p=0.091). Following an adjustment analysis involving a multivariate logistic regression, clinical pregnancy was still found to positively associate with secondary infertility (OR=2.51, p=0.008). Conclusion:IUI success in secondary infertile couples who were in the unexplained infertility and mild male subfertility groups was higher than that in primary infertile couples, and the chances of pregnancy increased as sperm numbers with +4 motility increased. It is difficult to concomitantly evaluate all these parameters and to determine a predictive parameter in IUI independent from other factors. (J Turk Ger Gynecol Assoc 2016; 17: 134-8) Keywords: Intrauterine insemination, unexplained infertility, male subfertility Received: 1 April, 2016 Accepted: 25 July, 2016 Factors affecting clinical pregnancy rates after IUI for the treatment of unexplained infertility and mild male subfertility

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“…Studies evaluating prognostic indicators for success in IUI cycles have indicated that duration of infertility is an important prognostic indicator. 11 The mean duration of infertility varied significantly between the pregnant and the non pregnant group (p value = 0.049). FSH levels greater than 10 IU/L have high specificity(80-100%) for predicting poor response to stimulation, but their sensitivity to identify such women is low and decreases with threshold value.…”

Section: Discussionmentioning

confidence: 95%