Infertility with Testicular Cancer

Ostrowski, Kevin; Walsh, Thomas J.

doi:10.1016/j.ucl.2015.05.003

Cited by 54 publications

(39 citation statements)

References 58 publications

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“…Neoplastic cells then shift to a glycolytic pathway for energy production instead of undergoing oxidative phosphorylation, which results in decreased mitochondrial activity (Warburg, ). Our results suggest either that removal of the affected testis removed a systemic effect, as has been suggested in other studies (Lambert & Fisch, ; Ostrowski & Walsh, ), which may have been a causative factor for the production of spermatozoa with lower mitochondrial activity in both testes. The former seems to be more likely, however, as most post‐orchiectomy samples were collected with less than a full spermatogenic cycle (up to 90 days, including epididymal maturation Neto, Bach, Najari, Li, & Goldstein, ) after removal of the affected testis.…”

Section: Discussionsupporting

confidence: 81%

Effect of orchiectomy on sperm functional aspects and semen oxidative stress in men with testicular tumours

et al. 2018

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To verify if quality of spermatozoa from men with testicular germ cell tumours is better before or after orchiectomy. This prospective study was carried out including 24 patients with testicular germ cell tumours, who provide one semen sample before they were submitted to unilateral orchiectomy and one other semen sample 30 days after the surgery. After collection by masturbation and liquefaction, an aliquot of the semen sample was used for semen analysis and another was used to evaluate sperm mitochondrial activity, DNA fragmentation and acrosome integrity. Seminal plasma was used to evaluate lipid peroxidation levels. Pre-orchiectomy sample and post-orchiectomy sample were compared using a paired Student's t test (normal distribution) or a paired Wilcoxon test, when appropriate (p ˂ 0.05). No significant difference was observed in semen analysis. A significant decrease in DNA fragmentation and lipid peroxidation and an increase in mitochondrial activity were observed after orchiectomy. Based on our findings, the semen quality from men with testicular germ cell tumours is better after orchiectomy. K E Y W O R D SDNA fragmentation, orchiectomy, oxidative stress, spermatozoa, testicular neoplasm How to cite this article: Andrade MBR, Bertolla RP, Intasqui P, et al. Effect of orchiectomy on sperm functional aspects and semen oxidative stress in men with testicular tumours.

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Section: Discussionsupporting

confidence: 81%

Effect of orchiectomy on sperm functional aspects and semen oxidative stress in men with testicular tumours

et al. 2018

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“…Another multicenter study conducted in France by River and colab., entitled "Spermatic aneuploidy after testicular cancer treatment" underlines the importance of genetic counseling regarding the high risk of sperm aneuploidy after radiotherapy and chemotherapy 10 . Aneuploidy is a major cause of the development of some fetal genetic syndromes, such as Down syndrome 12 . Also, it is important to delay the conceiving of a baby for 12 months for radiotherapy and more than 24 months for chemotherapy 12 .…”

Section: Fertility After Radiotherapymentioning

confidence: 99%

“…Aneuploidy is a major cause of the development of some fetal genetic syndromes, such as Down syndrome 12 . Also, it is important to delay the conceiving of a baby for 12 months for radiotherapy and more than 24 months for chemotherapy 12 .…”

Section: Fertility After Radiotherapymentioning

confidence: 99%

The Impact of Testicular Cancer on Fertility - Literature Review

Minciuna¹,

Creţu²,

Spinu³

et al. 2017

Rev. Med. Mod.

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This article is a literature review that emphasis the impact of testicular cancer on fertility and current management to prevent and treat infertility. Foreign literature has a lot of multicenter prospective longitudinal and retrospective studies of negative effects on fertility in men with teticular cancer. Testicular cancer has a negative impact on fertility because of its high incidence (7.52 cases per 100000 of the population) in young men with age between 15 and 35 years old. At the time they discover they have testicular cancer, many man have few or no sperm. In addition, all of the treatment for testicular cancer can directly or indirectly cause fetility problems. Sperm abnormatilies are frequent in men with testicular cancer. Patiens who underwent chemotherapy with bleomicin, doxorubicin, cisplatin or radiotherapy have a high risk to develop sperm aneuploidy. Genetic and psychological counseling should be done before choosing any treatment for testicular cancer. Sperm and embryo cryopreservation should be considered as early as possible before any treatement for testicular cancer.

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“…19 Testicular cancer is a known contributor to infertility, as it tends to occur in young, reproductive-aged men who are attempting to start families. 20,21 As survivorship has improved from cancer, especially pediatric cancers, more efforts have been put forth to study ways to preserve fertility for patients undergoing cancer treatments. 22,23 However, as more research has been completed, there is increasing evidence that infertility may also be an early marker of future malignancy.…”

Section: Introductionmentioning

confidence: 99%

Male Infertility and Risk of Cancer

Rogers

Walsh

2017

Semin Reprod Med

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Male infertility is a complex and incompletely understood process that is thought to affect around 10% of the male population. Infertility is a complex interaction between genetics and environmental factors, which is increasingly being recognized as a potential marker of contemporary or future medical disease, including cancer. The best characterized association between infertility and cancer risk is that of testicular germ cell tumor, but increased risk for prostate cancer, melanoma, non-Hodgkin's lymphoma, and others have also been described. Much like infertility, the mechanism behind these associations is not completely understood. Several hypotheses have been put forth including testicular dysgenesis syndrome, chromosomal abnormalities, damaged DNA repair mechanisms, or Y chromosome abnormalities. With the use of advance reproductive techniques, more men are bypassing a male fertility specialist who may be positioned to diagnose or counsel patients regarding these risks.

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Infertility with Testicular Cancer

Cited by 54 publications

References 58 publications

Effect of orchiectomy on sperm functional aspects and semen oxidative stress in men with testicular tumours

Effect of orchiectomy on sperm functional aspects and semen oxidative stress in men with testicular tumours

The Impact of Testicular Cancer on Fertility - Literature Review

Male Infertility and Risk of Cancer

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