Infiltrating Lobular Breast Cancer Presenting as Isolated Gastric Metastasis: a Case Report

Bushan, Kirti; Kammar, Praveen; Singh, Chandraveer; Advani, Suresh H.; Mahajan, Praveen

doi:10.1007/s13193-017-0705-7

Cited by 5 publications

(8 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…13 In addition, ILCs may produce a signet-ring morphology, which is easily confused with primary gastric carcinoma. 14…”

Section: Discussionmentioning

confidence: 99%

Gastric metastasis from breast cancer: five cases and a single-institutional review

Cheng,

Jia,

Zhang

et al. 2024

J Int Med Res

View full text Add to dashboard Cite

Gastric metastasis from breast cancer has a high rate of misdiagnosis and missed diagnosis. Data of patients who had gastric metastasis from breast cancer were retrieved from our hospital between 2014 and 2020. The gastric metastasis from breast cancer incidence was 0.04% (5/14,169 cases of breast cancer). Four patients had invasive lobular carcinoma, and the other patient had invasive ductal carcinoma. The time from the initial diagnosis of breast cancer to the appearance of gastric metastasis ranged from 0 to 12 years. One patient’s endoscopic presentation was similar to mucosal-associated lymphoid tissue lymphoma and presented with gastric mucosal congestion and edema, widened wrinkles, mixed color fading, and redness. The initial pathological diagnosis of this patient was mucosal-associated lymphoid tissue lymphoma, and breast cancer was finally confirmed by immunohistochemistry. Hormonal receptors were highly expressed in four patients with primary and metastasis lesions and were negative in one patient. Human epidermal growth factor receptor 2 was negative in all patients. Mammaglobin and GATA3 were positive in all patients. In conclusion, the gastric metastasis of breast cancer incidence rate is low, and misdiagnosis can lead to insufficient or excessive treatment. Multiple biopsies and immunohistochemistry should be performed to diagnose gastric metastasis of breast cancer.

show abstract

“…13 In addition, ILCs may produce a signet-ring morphology, which is easily confused with primary gastric carcinoma. 14…”

Section: Discussionmentioning

confidence: 99%

Gastric metastasis from breast cancer: five cases and a single-institutional review

Cheng,

Jia,

Zhang

et al. 2024

J Int Med Res

View full text Add to dashboard Cite

show abstract

“…Gastric metastases usually occur many years after primary breast cancer, so when the patient presents with these vague symptoms it's difficult to reconduct them to the primary causative disease. In our case reports, nine [23,28,29,35,37,38,39,43,45] of the patients had a wrong initial diagnosis and they were submitted to surgical treatment in the suspect of a primary gastric cancer.…”

Section: Symptomsmentioning

confidence: 91%

“…In 45 cases immunohystological study of the biopsies from gastric lesions or gastric wall were taken before starting any treatment; considering patients who underwent gastrectomy, nine [23,26,27,28,35,42,43,45] were taken after surgical treatment whereas three [23,28,43] were done before, but authors decided to perform surgery because they suspected primary gastric cancer or they couldn't exclude it.…”

Section: Gastric Tumor/receptormentioning

confidence: 99%

“…The preferred treatment is systemic therapy, as chemotherapy, endocrine therapy or a combination of both of them; 41 of the patients were subjected to chemotherapy with or without hormonal therapy. Combination of surgery and chemotherapy was used in 10 patients [23,28,29,35,[37][38][39]41,43,45] ; two of them [28,29] were submitted to neoadjuvant chemotherapy followed by surgery in the belief of a primary gastric cancer. Surgical treatment alone was chosen in 7 [26,27,42] patients, with three [27,42] of them in an emergency setting for bleeding and perforation.…”

Section: Therapymentioning

confidence: 99%

“…In general, surgery does not offer an increase in survival but may have role in palliation [53] . In our study surgery was also used to perform final diagnosis; gastric biopsies were confounding, thus authors performed gastrectomy to rule out the origin of the gastric disease [23,28,29,35,[37][38][39]43,45] .…”

Section: Therapymentioning

confidence: 99%

See 2 more Smart Citations

Breast cancer metastasis to the stomach

D’Angelo¹,

Rampini²,

Cardella³

et al. 2019

JCMT

View full text Add to dashboard Cite

Aim: This study focuses on the stomach as an unusual but not rare site of metastasis of breast cancer. Methods: We performed a literature search on gastric metastasis from breast cancer searching for reviews from 2000 to 2018 and case reports from 2013 to 2018. We found 11 reviews and 36 case reports and we compared their findings about important aspects of gastric metastasis, such as disease free survival, overall survival, symptoms, endoscopic findings, therapy, histology, and immunohistochemistry. Results: The incidence of stomach as site of metastasis of breast cancer ranges from 5% to 18%. Reviews and case reports reached similar conclusions about several of the aforementioned aspects: invasive lobular breast cancer (ILC) is mainly responsible for gastric metastases; disease free survival can vary greatly ranging from 0.5 months to 30 years; gastric metastases usually present with non-specific symptoms, even though five patients in case reports were asymptomatic; linitis plastica is the most common endoscopic finding; immunohistochemistry is essential for differentiating primary gastric cancer from metastasis; the preferred treatment is systemic therapy, but surgery is still an option in case of emergency; median overall survival of patients with gastric metastasis from breast cancer is 24 months. Conclusion: Breast metastasis to the stomach should be considered in any patient suspecting gastric neoplasm previously treated for breast carcinoma, especially if the treated carcinoma was ILC.

show abstract

Metastasis to the stomach: a systematic review

Ibrahimli,

Aliyev,

Majidli

et al. 2023

F1000Res

View full text Add to dashboard Cite

Background: This study reviews the literature on gastric metastases (GM) in terms of diagnosis, treatment, and outcomes. The goal of this study was to provide clinicians with a reliable and beneficial source to understand gastric metastases arising from various primary tumors and to present the growing literature in an easily accessible form. Methods: Articles published in English language from implementation of MEDLINE and Cochrane databases until May 2022 were considered for the systematic review. Articles other than English language, letters to the editor, posters, and clinical images were excluded. Hematogenous and lymphogenic metastases were included whereas direct tumoral invasion and seeding were excluded. Articles and abstracts were analyzed and last selection was done after cross-referencing and by use of defined eligibility criteria. Results: In total 1,521 publications were identified and 170 articles were finally included totaling 186 patients with GM. The median age of patients was 62 years. Gynecologic cancer was the most common cancer type causing GM (67 patients), followed by lung cancer (33 patients), renal cancer (20 patients), and melanoma (19 patients). One of the main treatment methods performed for metastasis was resection surgery (n=62), sometimes combined with chemotherapy (ChT) or immunotherapy. ChT was the other most used treatment method (n=78). Also, immunotherapy was amongst the most preferred treatment options after surgery and ChT (n=10). Conclusions: As 172 case reports were screened in the systematic review from different journals, heterogeneity was inevitable. Some articles missed important information such as complete follow-up or clinical information. Moreover, since all of the included articles were case reports quality assessment could not be performed. Among 172 case reports reviewed, resection surgery was performed the most and was sometimes combined with ChT and immunotherapy. Further research about what type of treatment has the best outcomes for patients with gastric metastases is needed.

show abstract

Infiltrating Lobular Breast Cancer Presenting as Isolated Gastric Metastasis: a Case Report

Cited by 5 publications

References 34 publications

Gastric metastasis from breast cancer: five cases and a single-institutional review

Gastric metastasis from breast cancer: five cases and a single-institutional review

Breast cancer metastasis to the stomach

Metastasis to the stomach: a systematic review

Contact Info

Product

Resources

About