Infiltrator angioplasty balloon catheter: A device for combined angioplasty and intramural site-specific treatment

Baráth, Péter; Popov, A.; Dillehay, Garry L.; Matos, Gabor; McKiernan, Thomas L.

doi:10.1002/(sici)1097-0304(199707)41:3<333::aid-ccd15>3.0.co;2-o

Cited by 30 publications

(4 citation statements)

References 6 publications

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“…2 A clinically applicable delivery device must meet the following requirements: (i) provide isolation and exposition of a vascular segment; (ii) maximize diffusion through the endothelium and basement membranes; (iii) result in high-efficiency penetration of the vascular wall while at the same time minimizing escape into the systemic circulation and perivascular space; (iv) minimize or eliminate the risk of vessel dissection or perforation; (v) permit downstream blood flow. 29 To address these requirements, several types of balloon catheters for percutaneous gene delivery were developed. 2,30,31 Double-balloon catheters (Figure 2a) were the first used for vascular gene therapy.…”

Section: Myocardial Gene-delivery Techniquesmentioning

confidence: 99%

Gene delivery technologies for cardiac applications

et al. 2012

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Ischemic heart disease (IHD) and heart failure (HF) are major causes of morbidity and mortality in the Western society. Advances in understanding the molecular pathology of these diseases, the evolution of vector technology, as well as defining the targets for therapeutic interventions has placed these conditions within the reach of gene-based therapy. One of the cornerstones of limiting the effectiveness of gene therapy is the establishment of clinically relevant methods of genetic transfer. Recently there have been advances in direct and transvascular gene delivery methods with the use of new technologies. Current research efforts in IHD are focused primarily on the stimulation of angiogenesis, modify the coronary vascular environment and improve endothelial function with localized gene-eluting catheters and stents. In contrast to standard IHD treatments, gene therapy in HF primarily targets inhibition of apoptosis, reduction in adverse remodeling and increase in contractility through global cardiomyocyte transduction for maximal efficacy. This article will review a variety of gene-transfer strategies in models of coronary artery disease and HF and discuss the relative success of these strategies in improving the efficiency of vector-mediated cardiac gene delivery.

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Section: Myocardial Gene-delivery Techniquesmentioning

confidence: 99%

Gene delivery technologies for cardiac applications

et al. 2012

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“…These catheters, which are thought to more efficiently deliver drugs intramurally compared to passive diffusion catheters, enable the physician to target the deeper medial and adventitial layers of the artery. 20,21 This family of devices includes the circumferential needle injection balloon catheter (NIBC) and the porous balloon catheter. The NIBC is a conventional over-the-wire balloon catheter that has been modified by the addition of small injection needles.…”

Section: Pressure-driven Balloon Cathetersmentioning

confidence: 99%

“…The NIBC is a conventional over-the-wire balloon catheter that has been modified by the addition of small injection needles. 19,20 Three longitudinal strips bearing 6 injection needles are shielded from the artery wall by careful folding of the balloon. These needles, which extend ϳ0.01 inch on the inflated balloon, penetrate the tunica media after balloon inflation; a fluid can be injected via a tuberculin syringe connected to the proximal end of the catheter by a 3-way stopcock.…”

Section: Pressure-driven Balloon Cathetersmentioning

confidence: 99%

Local Endovascular Delivery, Gene Therapy, and Cell Transplantation for Peripheral Arterial Disease

Opie

Dib

2004

J Endovasc Ther

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ࡗ ࡗAdvances in catheter technology, gene identification, and cell biology may provide novel treatment options for patients with peripheral arterial disease (PAD) who are not candidates for standard revascularization procedures. Animal studies and recent results in human beings suggest that transfer of growth factors or regulatory genes and transplantation of progenitor cells may provide novel therapy options by inducing therapeutic angiogenesis or by inhibiting restenosis. This review will discuss the development of a variety of catheters for localized endovascular delivery, as well as the various cellular and genetic strategies that exist to restore blood flow to ischemic tissue and to reduce neointimal hyperplasia. J Endovasc Ther 2004;11(Suppl II):II-151-II-162

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“…50 The Infiltrator ® (InterVentional Technology, Inc.) is a balloon catheter that features protruding rows of nipples that penetrate into the internal elastic artery on balloon inflation to deliver the drug or gene into the media and deeper layers of the wall with high efficiency. 51 Percutaneous adenovirus-mediated nitric oxide synthase gene transfer resulted in efficient local overexpression of functional nitric oxide synthase after angioplasty in porcine coronary arteries. Restored nitric oxide production in injured coronary arteries significantly reduced luminal narrowing.…”

Section: Electrical and Mechanical Devicesmentioning

confidence: 99%

Local drug delivery: an emerging approach in the treatment of restenosis

Ettenson

Edelman

2000

Vasc Med

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Very limited success has been demonstrated with systemic pharmacological treatment to reduce the incidence of restenosis following angioplasty in patients. The lack of success of many of the pharmacotherapeutic agents in reducing the restenosis rates post-angioplasty and following stent implementation is believed to arise from inadequate concentrations of the agents at the lesion site. This has led to the development of various local delivery devices that would ideally deliver and retain adequate amounts of drug to the vessel wall for sufficient periods of time to ensure a therapeutic effect without inducing further injury or compromising blood flow. Local dosing would avoid systemic toxicity, and the use of modified balloon catheters or coated stents might enable percutaneous approaches.

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Infiltrator angioplasty balloon catheter: A device for combined angioplasty and intramural site-specific treatment

Cited by 30 publications

References 6 publications

Gene delivery technologies for cardiac applications

Gene delivery technologies for cardiac applications

Local Endovascular Delivery, Gene Therapy, and Cell Transplantation for Peripheral Arterial Disease

Local drug delivery: an emerging approach in the treatment of restenosis

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