Infinite Elution Range in Micellar Electrokinetic Capillary Chromatography Using a Nonionic/Anionic Mixed Micellar System

Ahuja, Eric S.; Nielsen, Kurt R.; Foley, Joe P.; Little, Edward L.

doi:10.1021/ac00097a006

Cited by 62 publications

(24 citation statements)

References 16 publications

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“…The study of thermodynamical aspects of mixed micelles and their interactions with analytes has been also the focus of several papers taking into account their relevance upon the selectivity optimization [80][81][82][83][84][85][91][92][93][94][95][96][97][98][99][100][101]. Among them, several approaches can be remarked: (i) the Plackett-Burman statistical [94] and central composite [95] designs were used to optimize the high number of parameters affecting the MMS-MEKC separation; (ii) the solvation parameter model [98,99] aimed to study the influence of the MMS composition on the capacity of the micelle for intermolecular interactions; and (iii) the so-called infinite elution range, in which the electroosmotic and micellar electrophoretic mobilities are empirically adjusted so that a nearly stationary micellar phase is obtained [101].…”

Section: Mixed Micellesmentioning

confidence: 99%

Micellar electrokinetic chromatography: Current developments and future

Molina

Silva

2002

Electrophoresis

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This review highlights recent methodological and instrumental advances in micellar electrokinetic chromatography (MEKC). Enhancements in sensitivity and selectivity of the technique through the use of on-line preconcentration approaches (stacking and sweeping) and nonconventional pseudostationary phases, namely nonionic and zwitterionic surfactants, mixed micelles and polymers, are discussed in detail. Laser-induced fluorescence and mass spectrometry, as alternatives to UV-absorption detection, have been covered to evaluate their advantages and limitations when applied to analysis in an MEKC format. Some thoughts on future directions in this area such as in-capillary reactions, coated capillaries and MEKC on microchips are also presented.

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Section: Mixed Micellesmentioning

confidence: 99%

Micellar electrokinetic chromatography: Current developments and future

Molina

Silva

2002

Electrophoresis

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“…Ahuja et al [44] reported the adsorption of the polyether surfactant Brij onto the capillary wall. We presume that within a course of repeated separations, the adsorption of Triton X-100 might also take place, resulting in the drifting phenomena observed.…”

Section: Repeatabilitymentioning

confidence: 99%

Separation of very hydrophobic analytes by micellar electrokinetic chromatography. I. Optimization of the composition of the sample solution for the determination of the aromatic ingredients of sassafras and other essential oils of forensic interest

et al. 2008

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A micellar electrokinetic chromatographic method using UV and (UV)LIF detection in-line was developed for the determination of aromatic constituents, mainly allylbenzenes in essential oils. The method optimization included the optimization of the composition of the separation electrolyte using ACN and urea to reduce retention factors and CaCl(2) to widen the migration time window. In addition, it was necessary to optimize the composition of the sample solution which included the addition of a neutral surfactant at high concentration. With the optimized method, the determination of minor constituents in essential oils was possible despite of the presence of a structurally related compound being in a molar ratio excess of 1000:1. The use of UV and LIF-detection in-line enabled the direct comparison of the two detection traces using an electrophoretic mobility x-axis instead of the normal time-based scale. This simplifies the assignment of signals and enhances repeatability. The method developed was successfully applied to the determination of minor and major constituents in herbal essential oils, some of them being forensically relevant as sources of precursors for synthetic drugs.

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“…The Joule heating contributed by surfactants can be minimized by partially substituting a zwitterionic surfactant for the original charged surfactant. The same group [71] reported that a nearly infinite elution range in MEKC is feasible by using a nonionic/anionic mixed micellar system, which comprised of a mixture of nonionic poly(oxyethylene) (23) …”

Section: Mixed Systemsmentioning

confidence: 99%

Capillary electrophoresis separation of neutral organic compounds, pharmaceutical drugs, proteins and peptides, enantiomers, and anions

Ding

1999

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Infinite Elution Range in Micellar Electrokinetic Capillary Chromatography Using a Nonionic/Anionic Mixed Micellar System

Cited by 62 publications

References 16 publications

Micellar electrokinetic chromatography: Current developments and future

Micellar electrokinetic chromatography: Current developments and future

Separation of very hydrophobic analytes by micellar electrokinetic chromatography. I. Optimization of the composition of the sample solution for the determination of the aromatic ingredients of sassafras and other essential oils of forensic interest

Capillary electrophoresis separation of neutral organic compounds, pharmaceutical drugs, proteins and peptides, enantiomers, and anions

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