Inflammaging and the Lung

Kovacs, Elizabeth J.; Boe, Devin M.; Boule, Lisbeth A.; Curtis, Brenda J.

doi:10.1016/j.cger.2017.06.002

Cited by 46 publications

(45 citation statements)

References 114 publications

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“…The low‐grade subclinical pro‐inflammatory status found in the elderly likely exerts additional influence on the inflammatory responses of macrophages. Indeed, several studies suggest that aged macrophages produce higher cytokine levels in vivo yet reduced secretion in vitro . This paradox reflects our results and highlights the role of the aging microenvironment over cell‐intrinsic defects in dictating the host response to implant material.…”

Section: Discussionsupporting

confidence: 74%

Effect of Aging on the Macrophage Response to Titanium Particles

Jämsen

Pajarinen

Lin

et al. 2019

Journal Orthopaedic Research

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Macrophage-mediated inflammatory reaction to implant wear particles drives bone loss around total joint replacements (TJR). Although most TJR recipients are elderly, studies linking wear particle-activated macrophages and peri-implant osteolysis have not taken into account the multiple effects that aging has on the innate immune system and, in particular, on macrophages. To address this, we compared the wear particle responses of bone marrow macrophages obtained from young (2-month) and aged (18-month) mice. Macrophages were polarized to M0, M1, or M2 phenotypes in vitro, challenged with titanium particles, and their inflammatory response was characterized at multiple time points by quantitative reverse-transcription polymerase chain reaction and enzyme-linked immunosorbent assay. In addition, age-dependent changes in activation of transcription factor nuclear factor-κB were analyzed by a lentiviral vector-based luciferase reporter system. The particle stimulation experiment was further repeated using human primary macrophages isolated from blood donors of different ages. We found that the pro-inflammatory responses were generally higher in macrophages obtained from young mice, but differences between the age groups remained small and of uncertain biological significance. Noteworthily, M2 polarization effectively suppressed the particle-induced inflammation in both young and aged macrophages. These results suggest that aging of the innate immune system per se plays no significant role in the response of macrophages to titanium particles, whereas induction of M2 polarization appears a promising strategy to limit macrophage-mediated inflammation regardless of age.

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Section: Discussionsupporting

confidence: 74%

Effect of Aging on the Macrophage Response to Titanium Particles

Jämsen

Pajarinen

Lin

et al. 2019

Journal Orthopaedic Research

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“…This physiological condition is called inflamm-aging [ 5 ], and it may predispose to the development of inflammatory diseases [ 4 , 6 , 7 , 8 ]. The recent literature suggests that inflamm-aging causes immunosenescence [ 9 ]. The efficacy of oxidative metabolism, that is, the ability of endogenous antioxidants to counterbalance the production of reactive oxygen species (ROS) that are physiologically produced by many cellular metabolic processes, also decreases with age, which contributes to establishment of the aging-associated inflammatory milieu (oxi-inflamm-aging) [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Among the body systems, the respiratory apparatus is one of the most exposed to continuous external antigenic load and atmospheric oxygen, which represent risk factors for the development of exaggerated immune responses and oxidative stress manifesting as allergic or other inflammatory reactions, as it occurs in asthma [ 15 ]. Given the predominance of macrophages among the inflammatory cell types within the alveoli, and the central role of the macrophages in the phenomenon of inflamm-aging, the lung could be considered as an organ that is at high risk of developing exaggerated inflammatory responses during aging [ 9 ]. Asthma in the elderly is a phenotype that is characterized epidemiologically by higher morbidity and mortality rates when compared to adult asthma, and clinically by a neutrophilic rather than eosinophilic inflammation, by less frequent atopy, by the presence of numerous comorbidities, and by a blunted response to treatment [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

The Contribution of Oxidative Stress and Inflamm-Aging in Human and Equine Asthma

Bullone

Lavoie

2017

IJMS

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Aging is associated with a dysregulation of the immune system, leading to a general pro-inflammatory state of the organism, a process that has been named inflamm-aging. Oxidative stress has an important role in aging and in the regulation of immune responses, probably playing a role in the development of age-related diseases. The respiratory system function physiologically declines with the advancement of age. In elderly asthmatic patients, this may contribute to disease expression. In this review, we will focus on age-related changes affecting the immune system and in respiratory structure and function that could contribute to asthma occurrence, and/or clinical presentation in the elderly. Also, naturally occurring equine asthma will be discussed as a possible model for studying the importance of oxidative stress and immun-aging/inflamm-aging in humans.

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“…Immunosenescence and its associated chronic low-grade systemic “inflamm aging” contribute to the development and progression of pulmonary disease in older individuals. 59 – 61 Many other alterations, which affect both the innate and adaptive immune systems, have been described, which cannot be addressed in detail in this review. 62 – 66 All these lead to a decline of the ability to generate an adequate immune response and thus increasing the susceptibility to bacterial infections, including pneumonia.…”

Section: Pneumococcal Vaccination In the Elderlymentioning

confidence: 99%

Triptych of the Hermit Saints: pneumococcal polysaccharide vaccines for the elderly

Rijkers

Yousif

Spoorenberg

et al. 2018

RMHP

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Pneumococcal pneumonia is a serious disease with considerable morbidity and mortality in the elderly. Despite adequate antibiotic treatment, the long-term mortality of pneumococcal pneumonia remains high. Preventive measures in the form of vaccination, therefore, are warranted. Twenty-three-valent polysaccharide vaccines have a broad coverage but limited efficacy. Pneumococcal conjugate vaccines have been shown in children to be able to prevent invasive and mucosal pneumococcal diseases. It should be realized that the serotype composition of current pneumococcal conjugate vaccines is not tailored for the elderly, and that replacement disease can occur. Yet, the current 13-valent conjugate vaccine has been shown to protect against infections with vaccine serotypes. Long-term mortality of pneumococcal pneumonia should be included in policy making about the introduction of these vaccines for the elderly.

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Inflammaging and the Lung

Cited by 46 publications

References 114 publications

Effect of Aging on the Macrophage Response to Titanium Particles

Effect of Aging on the Macrophage Response to Titanium Particles

The Contribution of Oxidative Stress and Inflamm-Aging in Human and Equine Asthma

Triptych of the Hermit Saints: pneumococcal polysaccharide vaccines for the elderly

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