Inflammasomes—New Contributors to Blood Diseases

Tomasik, Jaromir; Basak, Grzegorz W.

doi:10.3390/ijms23158129

Cited by 15 publications

(6 citation statements)

References 79 publications

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“…However, heavily transfused patients with thalassemia only show a few cases of cancer [ 69 ]. Chronic inflammation implies the potential involvement of inflammasomes in SCD pathogenesis [ 70 ]. Chronic organ damage with inflammation could also cause cellular damage with subsequent malignant transformation.…”

Section: Discussionmentioning

confidence: 99%

Sickle cell disease and acute leukemia: one case report and an extensive review

et al. 2023

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Population-based studies and case reports suggest that there may be an increased risk of acute leukemia associated with sickle cell disease (SCD). Following the description of a new case report, an extensive review of the literature identified 51 previously described cases. Most cases study showed myelodysplastic features confirmed, when available, by genetic markers such as chromosome 5 and/or chromosome 7 abnormalities and TP53 gene mutations. The increased risk of leukemogenesis is certainly multifactorial and related to the pathophysiologic mechanisms of the clinical manifestations of SCD. Chronic hemolysis and secondary hemochromatosis may cause increased chronic inflammation, resulting in persistent marrow stress, which could potentially compromise the genomic stability of the hematopoietic stem cells generating genomic damage and somatic mutations over the course of SCD and its treatment, resulting in a clone that led to acute myeloid leukemia.

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Section: Discussionmentioning

confidence: 99%

Sickle cell disease and acute leukemia: one case report and an extensive review

et al. 2023

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“…Inflammasomes are multiprotein complexes that primarily reside in the cytoplasm of innate immune cells ( 16 ). However, they are also present in lymphocytes and epithelial cells.…”

Section: The Classification Of Inflammasomesmentioning

confidence: 99%

Pyroptosis: a new insight into intestinal inflammation and cancer

Chao,

Zhang,

Feng

et al. 2024

Front. Immunol.

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Pyroptosis is an innate immune response triggered by the activation of inflammasomes by various influencing factors, characterized by cell destruction. It impacts the immune system and cancer immunotherapy. In recent years, the roles of pyroptosis and inflammasomes in intestinal inflammation and cancer have been continuously confirmed. This article reviews the latest progress in pyroptosis mechanisms, new discoveries of inflammasomes, mutual regulation between inflammasomes, and their applications in intestinal diseases. Additionally, potential synergistic treatment mechanisms of intestinal diseases with pyroptosis are summarized, and challenges and future directions are discussed, providing new ideas for pyroptosis therapy.

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“…The NLR family inflammatory bodies are activated by various exogenous and endogenous drugs, and then promote and enhance the inflammatory response. NLRC4 inflammatory corpuscles are considered to be the main promoter of Hemophagocytic lymphohistiocytosis (Schulert and Cron, 2020;Tomasik and Basak, 2022). Hemophagocytic lymphohistiocytosis is a disease characterized by immune system damage associated with excessive inflammation.…”

Section: Function Classification Of Degsmentioning

confidence: 99%

RNA sequencing provides insights into the effect of dietary ingestion of microplastics and cadmium in the sea cucumber Apostichopus japonicus

Zhang

Zhang²,

Mohsen³

et al. 2023

Front. Mar. Sci.

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IntroductionMicroplastics (MPs) and cadmium (Cd) are persistent pollutants in aquatic environments. Sea cucumbers are susceptible to MPs and Cd due to their feeding behavior.MethodsThis study, based on Illumina sequencing, compared the transcriptomes of A. japonicus before and after Cd and/or MPs exposure. Additionally, we detected the changes of catalase (CAT), and superoxide dismutase (SOD) activity, glutathione (GSH), and malondialdehyde (MDA) content in sea cucumbers.Results and DiscussionHigh concentration of MPs caused the increase of SOD activity. High concentration combined treatment resulted in significant up regulation of these four indicators in A. japonicus and had the largest number of differential expression genes (DEGs) reaching 1,618 DEGs, consisting of 789 up regulated along with 829 down regulated DEGs. Transcriptome results showed that Cd induced up regulation of intestinal FAS associated death domain protein (FADD) expression, which may cause apoptosis and inflammation. The increase of intestinal putative heparan sulfate 2-O-sulfotransferase in cadmium treatment groups provided a mechanism for host defense. The imbalance of expression of the NOD-like receptor (NLR) family inflammatory bodies and caspase 6 in the microplastic treatment group also led to the inflammatory reaction in the intestine of sea cucumber. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that in the process of fatty acid metabolism, MPs and Cd showed antagonistic effects, mainly in the inconsistent expression of Stearoyl CoA Ddesaturase (SCD1) protein. The significant changes of Toll interacting protein (TOLLIP) and E-selectin (SELE) in all Cd and MPs treatment groups may indicate the key immune response genes of sea cucumber to Cd exposure and MPs exposure. These genes were involved in the immune defense of sea cucumber exposed to different levels of Cd and MPs. This study provided insights into the mechanism of dietary MPs and Cd intake in an economically and ecologically important invertebrate species.

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Inflammasomes—New Contributors to Blood Diseases

Cited by 15 publications

References 79 publications

Sickle cell disease and acute leukemia: one case report and an extensive review

Sickle cell disease and acute leukemia: one case report and an extensive review

Pyroptosis: a new insight into intestinal inflammation and cancer

RNA sequencing provides insights into the effect of dietary ingestion of microplastics and cadmium in the sea cucumber Apostichopus japonicus

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