Inflammation as a modulator of the HDL cholesterol-induced inteleukin-10 production by human circulating mononuclear cells

Coronado, Mónica Torres; Pozzi, Aranzazu Ortega; Punchard, Marie Anne; González, Pablo; Fantidis, Panayotis

doi:10.1016/j.atherosclerosis.2008.03.015

Cited by 8 publications

(7 citation statements)

References 10 publications

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“…Besides, HDL can induce the production of IL-10 which is an anti-inflammatory and atheroprotective cytokine. 26 However, in our study, H. pylori- positive dyspeptic patients’ serum HDL levels were significantly reduced due to the metabolic and inflammatory effect of H. pylori infection as a result, they are potentially at higher risk for atherosclerosis and other cardiovascular diseases.…”

Section: Discussioncontrasting

confidence: 51%

“…Inflammation caused by H. pylori infection is bringing significant changes in the protein (apoA-I), and lipid content of HDL, as well as reducing the concentration of HDL. 26 Inflammation causes an increase in reactive oxygen species such as Myeloperoxidase and superoxide anion radical, that resulting in the generation of oxidized and modified lipoproteins and reduce the concentration of HDL. 27 The metabolic effects of H. pylori infection are mediated by cytokines, predominantly TNF-α, which inhibit lipoprotein lipase and that results in the mobilization of lipids from tissues along with an increase in serum TG and decrease in HDL levels.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Lipid Profile and Inflammatory Marker in Patients with Gastric Helicobacter pylori Infection, Ethiopia

GB¹,

Menon²,

Gizaw³

et al. 2022

IJGM

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Introduction H. pylori are gram-negative, microaerophilic helical-shaped bacteria with multiple flagella and commonly exist in the stomach. This infection may cause significant mucosal inflammation and damage, leading to ulcers in the stomach. It can also affect organ systems external to the gastrointestinal tract. To assess cardiovascular risk factors and to predict cardiovascular disorders, we are evaluating and comparing lipid profile and inflammatory marker between H. pylori- positive and negative patients. Objective To evaluate and compare lipid profile (TC; TG; LDL; HDL) and inflammatory marker (hs-CRP) in dyspeptic patients with and without H. pylori infection. Methods Comparative cross-sectional study was conducted from September 2020 to January 2021 at Debre Markos Referral Hospital, Debre Markos Health Center, and Hidassie Health Center, Ethiopia. Each of 50 H. pylori -positive and negative dyspeptic patients were studied. The data were checked for completeness and analyzed by SPSS version 25.0 Software. A p-value < 0.05 was considered statistically significant. Results Serum mean high-density lipoprotein (HDL) values were 37.54 ± 7.98 mg/dL and 43.12 ± 7.86 mg/dL (p < 0.05) for H. pylori -positive and negative dyspeptic patients, respectively, and median serum high sensitive C reactive protein (hs-CRP) levels were 6.29 mg/L (1.66–41.34) and 3.35 mg/L (0.39–10.01) (p < 0.05) for H. pylori -positive and negative dyspeptic patients, respectively. Conclusion H. pylori infection significantly alters serum high-density lipoprotein (HDL) and high sensitive C reactive protein (hs-CRP) levels in dyspeptic patients, as a result, increase the potential risk of cardiovascular diseases.

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Section: Discussioncontrasting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Evaluation of Lipid Profile and Inflammatory Marker in Patients with Gastric Helicobacter pylori Infection, Ethiopia

GB¹,

Menon²,

Gizaw³

et al. 2022

IJGM

View full text Add to dashboard Cite

show abstract

“…HDL-cholesterol can regulate the production of cytokines by itself. Inflammation, by changing the level of HDL-cholesterol, stimulates the production of IL-10 by circulating mononuclear cells [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…The H. pylori eradication therapy increases apo A and HDL-cholesterol, while total cholesterol and LDL are not changed [ 28 , 29 ]. A randomized clinical trial evaluated the long-term effect of garlic and nutritional supplements, with a 2-week antibiotic therapy regimen on the treatment of h. pylori infection, and lipoproteins and cholesterol profiles [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Helicobacter pylori Infection on Serum Lipid Profile

et al. 2018

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Background Some studies suggest a significant relationship between Helicobacter pylori infection and atherogenesis; but the mechanism of the relationship is almost unknown. The current study aimed at evaluating the relationship between H. pylori infection and serum lipid profile. Patients and Methods The current study was conducted on 2573 patients, from 2008 to 2015. The serum anti-Helicobacter pylori antibody titer and serum lipid profile were assessed in the study population; data were statistically analyzed by SPSS version 16. P values < 0.05 were considered significant. Results In the current study, 66.5% of the cases were serologically positive for H. pylori. Among male cases, the level of low density lipoprotein (LDL) was higher in patients with H. pylori infection, compared with that of the ones without the infection (P = 0.03); although level of triglyceride (TG) was higher and the level of high density lipoprotein (HDL) was lower in the cases with H. pylori infection; there was no statistically significant difference between the cases with and without H. pylori infection regarding the level of HDL and TG. Among female cases, the level of TG was significantly lower in patients with H. pylori infection, compared with that of the ones without the infection (P = 0.001); but there was no significant difference between the cases with and without H. pylori infection regarding the level of LDL and HDL. The mean fasting blood sugar (FBS) in the cases with H. pylori infection was significantly higher than that of the ones without the infection (P = 0.04). Conclusion According to the results of the current study, the levels of LDL and FBS were high among the male cases with H. pylori infection. However, in females with H. pylori infection the level of TG was low; hence, it seems that the atherogenicity of H. pylori affected the level of blood sugar more.

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“…HDL can bind and remove active TNF-α [18], whereas apo A-I inhibits the production of the pro-inflammatory cytokines IL-1β and TNF-α by blocking contact-mediated activation of monocytes by T lymphocytes [150][151][152]. On the other hand, HDL and apo A-I can induce the expression of the antiinflammatory cytokine IL-10 [153,154] in mononuclear cells. Besides the modulation of the cytokine profile, HDL can counteract monocyte-endothelial cell interactions.…”

Section: Anti-inflammatory Features Of High-density Lipoproteinsmentioning

confidence: 99%

Cardiac Effects of HDL and Its Components on Diabetic Cardiomyopathy

Spillmann¹,

Linthout²,

Tschöpe³

2012

EMIDDT

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Diabetic cardiopathy includes a specific cardiomyopathy, which occurs in the absence of coronary heart disease and hypertension under diabetes mellitus. Hyperglycemia, hyperinsulinemia, and hyperlipidemia, characteristic metabolic disturbances evident in diabetes mellitus, all three lead to a specific altered cardiac structure and function. Recently, it has been demonstrated that altered HDL, be it low HDL or dysfunctional HDL is not only a consequence of diabetes mellitus, but can also contribute to the development of diabetes mellitus, and therefore also of diabetic cardiomyopathy. This review summarizes how HDL can indirectly affect diabetic cardiomyopathy via their influence on the metabolic triggers hyperglycemia, hyperinsulinemia, and hyperlipidemia, and how they can directly influence the cardiac cellular consequences, typical for diabetic cardiomyopathy, including inflammation, oxidative stress, apoptosis, fibrosis, Ca2+ handling, glucose homeostasis, and endothelial dysfunction.

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Inflammation as a modulator of the HDL cholesterol-induced inteleukin-10 production by human circulating mononuclear cells

Cited by 8 publications

References 10 publications

Evaluation of Lipid Profile and Inflammatory Marker in Patients with Gastric Helicobacter pylori Infection, Ethiopia

Evaluation of Lipid Profile and Inflammatory Marker in Patients with Gastric Helicobacter pylori Infection, Ethiopia

Effect of Helicobacter pylori Infection on Serum Lipid Profile

Cardiac Effects of HDL and Its Components on Diabetic Cardiomyopathy

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