Inflammation as a Predictor of Abdominal Aortic Aneurysm Growth and Rupture: A Systematic Review of Imaging Biomarkers

Noninvasive aortic imaging

“…Authors conclude that the evidence provided by these studies is contradictory; results vary widely from significant negative correlations to non-significant positive associations between 18 F-FDG uptake and AAA growth. At the present time, 18 F-FDG-PET/CT is not recommended for use as a growth or rupture prediction tool in routine practice (78). Early work on 18 F-FDG-PET/CT revealed the presence of focal vascular FDG uptake unrelated to calcified plaques in patients undergoing PET-CT for malignant conditions (79), suggesting that it may possibly be located in areas of metabolically active atherosclerosis.…”

“…Aortic FDG uptake has also attracted research interests for predicting the risk of adverse outcome in aortic aneurysms and its performance has been evaluated in several studies (74)(75)(76)(77). A recent systematic review evaluated the performance of aortic 18 F-FDG-PET/CT by pooling the results of various PET-CT studies (78). Authors conclude that the evidence provided by these studies is contradictory; results vary widely from significant negative correlations to non-significant positive associations between 18 F-FDG uptake and AAA growth.…”

A comprehensive literatures update of clinical researches of superparamagnetic resonance iron oxide nanoparticles for magnetic resonance imaging

“…That 18 F-FDG PET-CT and USPIO-MRI uptake distinct differences in the pattern and distribution of uptake, suggesting a differential detection of macrophage glycolytic and phagocytic activity respectively. In a systematic review paper Jalalzadeh et al (113) reported that relationship between inflammatory processes (as evaluated by 18 F-FDG uptake and USPIO enhanced MRI) and AAA progression remains unclear. To address these issues, the MA (3) RS study (350 patients expected) at Edinburgh and Glasgow is currently on-going and expects to report in 2017 (114) (Figure 11).…”

Aneurysm Wall Enhancement Detected by Contrast Computed Tomography Scan Is Associated With Aneurysm Shrinkage After Endovascular Aneurysm Repair for Abdominal Aortic Aneurysm

“…rupture. 22 The mechanism of 18 F-FDG uptake and aneurysm rupture is that chronic inflammation with proteolytic degradation of the aortic wall is the principal cause of aortic wall weakening and aneurysm growth. Edjlali et al reported that AWE in cerebral aneurysm was an independent risk factor with unstable status.…”