Inflammation-associated gene transcription and expression in mouse lungs induced by low molecular weight compounds from fungi from the built environment

Miller, J. David; Sun, Mengyao; Gilyan, A.; Roy, Jennifer D.; Rand, Thomas

doi:10.1016/j.cbi.2009.09.023

Cited by 75 publications

(58 citation statements)

References 60 publications

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“…45) Miller et al demonstrated that 25 induced inflammatory gene responses in mouse lungs and mouse alveolar macrophages. 56,57) 1. Synthesis of neoechinulin A Synthesis of 25 has been reported by Yonemitsu et al 58) and Nakatsuka et al, 59) but the absolute configuration of natural 25 was not determined because racemization of the diketopiperazine moiety occurred readily during the synthetic processes.…”

Section: )mentioning

confidence: 99%

Synthetic and Structure-Activity Relationship Studies on Bioactive Natural Products

Kuramochi

2013

Bioscience, Biotechnology, and Biochemistry

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Section: )mentioning

confidence: 99%

Synthetic and Structure-Activity Relationship Studies on Bioactive Natural Products

Kuramochi

2013

Bioscience, Biotechnology, and Biochemistry

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“…growing on damp building materials do not readily become airborne and/or lose their culturability soon after liberation (21,29,45,47) and may therefore not be detected during air or dust sampling. Correct species identification of the fungi is also important, since new research has indicated that species-specific metabolites, like atranone C produced by Stachybotrys chlorohalonata (37), are cytotoxic or immunotoxic or induce inflammatory responses when inhaled (24,33,34). The purpose of this study was therefore to estimate the qualitative and quantitative diversity of fungi growing on damp or water-damaged building materials.…”

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confidence: 99%

Associations between Fungal Species and Water-Damaged Building Materials

Andersen

Frisvad

Søndergaard

et al. 2011

Appl Environ Microbiol

308

280

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Fungal growth in damp or water-damaged buildings worldwide is an increasing problem, which has adverse effects on both the occupants and the buildings. Air sampling alone in moldy buildings does not reveal the full diversity of fungal species growing on building materials. One aim of this study was to estimate the qualitative and quantitative diversity of fungi growing on damp or water-damaged building materials. Another was to determine if associations exist between the most commonly found fungal species and different types of materials. More than 5,300 surface samples were taken by means of V8 contact plates from materials with visible fungal growth. Fungal identifications and information on building material components were analyzed using multivariate statistic methods to determine associations between fungi and material components. The results confirmed that Penicillium chrysogenum and Aspergillus versicolor are the most common fungal species in water-damaged buildings. The results also showed Chaetomium spp., Acremonium spp., and Ulocladium spp. to be very common on damp building materials. Analyses show that associated mycobiotas exist on different building materials. Associations were found between (i) Acremonium spp., Penicillium chrysogenum, Stachybotrys spp., Ulocladium spp., and gypsum and wallpaper, (ii) Arthrinium phaeospermum, Aureobasidium pullulans, Cladosporium herbarum, Trichoderma spp., yeasts, and different types of wood and plywood, and (iii) Aspergillus fumigatus, Aspergillus melleus, Aspergillus niger, Aspergillus ochraceus, Chaetomium spp., Mucor racemosus, Mucor spinosus, and concrete and other floor-related materials. These results can be used to develop new and resistant building materials and relevant allergen extracts and to help focus research on relevant mycotoxins, microbial volatile organic compounds (MVOCs), and microparticles released into the indoor environment.Most water damage indoors is due to natural disaster (e.g., flooding) or human error (e.g., disrepair). Water can seep into a building as a result of melting snow, heavy rain, or sewer system overflow. Water vapor can be produced by human activities like cooking, laundering, or showering and then condense on cold surfaces like outer walls, windows, or furniture. Damp or water-damaged building materials are at high risk of fungal growth (mold growth), possibly resulting in health problems for the occupants and the deterioration of the buildings. The water activity (a w ) (a w ϫ 100 ϭ % relative humidity at equilibrium) of a building material is the determining factor for fungal growth and varies with the temperature and the type of material (27). The longer a material's a w is over 0.75, the greater the risk of fungal growth (49), though different fungi have different a w preferences (11). Some filamentous fungi can grow on a material when the a w is as low as 0.78 (26), while others can survive 3 weeks at an a w of 0.45 (30). The severity of indoor dampness varies with the climate, but WHO (52) estimates that in Austral...

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“…Identification of mycotoxins and secondary metabolites produced by fungi may be of interest for assessing fungal health hazards, especially in the case of known mycotoxin producers. (3,4) Aspergillus oryzae, a member of the Flavi section, is widely used in traditional Japanese fermentation industries, including soy sauce, sake, bean curd seasoning, and vinegar production. (5) This species is closely related to A. flavus, another member of the Flavi section.…”

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confidence: 99%

Jewelry Boxes Contaminated byAspergillus oryzae: An Occupational Health Risk?

Bellanger

Roussel

Millon

et al. 2012

Journal of Occupational and Environmental Hygiene

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In 2009, 100,000 jewelry boxes, manufactured in China, were delivered to a jewelry manufacturer in Besançon, France. All the boxes were contaminated by mold. Because the workers refused to handle these jewelry boxes, the company contacted our laboratory to determine how to deal with the problem. Three choices were available: (1) decontaminate the boxes, (2) return the boxes to the Chinese manufacturer, or (3) destroy the entire shipment. Based on microscopic identification, the culture analysis was positive for A. oryzae. This could not be confirmed by molecular techniques because of the genetic proximity of A. oryzae and A. flavus. Because A. flavus can produce aflatoxins, we tested for them using mass spectrometry. Aflatoxins B1, B2, G1, G2, and M1 were not detected; however, given the specifics of this situation, we could not discard the possibility of the presence of other aflatoxins, such as P1, B3, GM2, and ethoxyaflatoxin B2. We concluded that the contamination by A. oryzae was probably due to food products. However, because of the possible presence of aflatoxins, occupational health risks could not be entirely ruled out. The decision was therefore taken to destroy all the jewelry boxes by incineration. To avoid a similar situation we propose: (1) to maintain conditions limiting mold contamination during production (not eating on the work site, efficient ventilation systems); (2) to desiccate the products before sending them; and (3) to closely control the levels of dampness during storage and transport.

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Inflammation-associated gene transcription and expression in mouse lungs induced by low molecular weight compounds from fungi from the built environment

Cited by 75 publications

References 60 publications

Synthetic and Structure-Activity Relationship Studies on Bioactive Natural Products

Synthetic and Structure-Activity Relationship Studies on Bioactive Natural Products

Associations between Fungal Species and Water-Damaged Building Materials

Jewelry Boxes Contaminated byAspergillus oryzae: An Occupational Health Risk?

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