Inflammation-Associated Microbiota Composition Across Domestic Animals

Hashimoto-Hill, Seika; Alenghat, Theresa

doi:10.3389/fgene.2021.649599

Cited by 12 publications

(10 citation statements)

References 84 publications

(119 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, the dominant phyla found in the donkey fecal microbiota in all groups were Firmicutes and Bacteroidetes ( Figure 3A ), consistent with previous studies showing that the most abundant phyla were Firmicutes and Bacteroidetes with respect to the breeding stages ( Kong et al, 2016 ; Cheng et al, 2018 ; Shao et al, 2020 ). In the equine gut, Firmicutes generally displays the highest relative abundance, followed by Bacteroidetes ( Venable et al, 2016 ; Hashimoto-Hill and Alenghat, 2021 ), which is similar to our study. Furthermore, we found that the relative abundance of the phylum Firmicutes was highest in EP, whereas Bacteroidetes showed the opposite result.…”

Section: Discussionsupporting

confidence: 91%

“…Polyketide-synthesizing bacteria are strongly associated with chronic intestinal inflammation ( Arthur et al, 2012 ). Moreover, in post-weaning diarrhea pigs, the increased abundance of the type II polyketide product biosynthesis pathway might be responsible for the increased inflammatory response ( Dou et al, 2017 ; Hashimoto-Hill and Alenghat, 2021 ). However, stilbenoid diarylheptanoid and gingerol, secondary metabolites of plants, have been reported to have anti-inflammatory or anticancer activities ( Park et al, 1998 ; Yadav et al, 2003 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Metabolic Alternations During Gestation in Dezhou Donkeys and the Link to the Gut Microbiota

Liu

et al. 2022

Front. Microbiol.

View full text Add to dashboard Cite

The maternal intestinal microbial community changes dramatically during pregnancy and plays an important role in animal growth, metabolism, immunity and reproduction. However, our understanding of microbiota compositional dynamics during the whole pregnancy period in donkey is incomplete. This study was carried out to evaluate gut microbiota alterations as well as the correlation with serum biochemical indices, comparing pregnant donkeys to non-pregnant donkeys. A total of 18 pregnant (including EP, early-stage pregnancy; MP, middle-stage pregnancy and LP, late-stage pregnancy) and six non-pregnant (C as a control) donkey blood samples and rectum contents were collected. The results showed that pregnant donkeys had higher microbial richness than non-pregnant donkeys and that the lowest microbial diversity occurred at the EP period. Moreover, the relative abundances of the families Clostridiaceae and Streptococcaceae were significantly higher in the EP group (p < 0.05) than that in the C and MP groups, while the relative abundances of the families Lachnospiraceae and Rikenellaceae were significantly lower in the EP group (p < 0.05) than that in the C group. The predicted microbial gene functions related to the inflammatory response and apoptosis, such as Staphylococcus aureus infection, the RIG-1-like receptor signaling pathway and apoptosis, were mainly enriched in EP. Furthermore, pregnant donkeys had higher glucose levels than non-pregnant donkeys, especially at EP period. EP donkeys had lower triglyceride, total protein and albumin levels but higher malondialdehyde, interleukin 1β, interleukin 6 and tumor necrosis factor-α levels than those in the C and MP groups. Additionally, there were strong correlations between inflammatory cytokine levels and the relative abundances of genera belonging to the Clostridiaceae and Streptococcaceae families. This is the first comparative study performed in donkeys that indicates that pregnancy status (especially in the early pregnancy period) alters the gut microbiota composition, which was correlated with serum biochemical parameters. These results could provide useful information for improving the reproductive management in Dezhou donkeys.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Metabolic Alternations During Gestation in Dezhou Donkeys and the Link to the Gut Microbiota

Liu

et al. 2022

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…The decreased abundance of several members of the Bacteroidetes such as ASVs belonging to the genera Bacteroides and Pevotella detected in this study have been previously reported in IBD in dogs and human (Hashimoto-Hill and Alenghat, 2021;Lee and Chang, 2021). Increase in other bacterial types such as Clostridium, Escherichia-Shigella and Streptococcus has been also previously reported (Honneffer et al, 2014).…”

Section: Discussionsupporting

confidence: 83%

Gut Microbiome Signatures of Yorkshire Terrier Enteropathy during Disease and Remission

Doulidis

Galler

Hausmann

et al. 2022

Preprint

View full text Add to dashboard Cite

The role of the faecal microbiome in the pathogenesis of both human and canine inflammatory bowel disease (IBD) has been in the spotlight in recent years. While trying to unravel the mechanism of IBD, clear alterations in intestinal microbial composition in individuals with IBD have been reported in the past. However, data in veterinary medicine are still scarce and inconsistent. Currently, the exact role of the gut microbiota alterations in the different phenotypes of canine chronic enteropathies and the impact of treatment on it are not well established. The objective of this study was to investigate the difference in the gut microbiome composition of Yorkshire Terriers with breed specific IBD, or Yorkshire Terrier Enteropathy (YTE), during disease and remission compared to healthy Yorkshire Terriers. Microbiome analysis of YTE was mainly characterised by a significant relative enrichment in taxa including Clostrodium sensu stricto 1, Escherichia-Shigella, Streptococcus and decrease in Bacteroides, Prevotella, Alloprevotella and Phascolarctobacterium compared to healthy controls. There was no significant difference in the microbiome composition of dogs in remission and dogs with active disease, indicating a longer lasting perturbation even beyond clinical recovery.

show abstract

“…Our study proposes a new nutritional strategy for improving intestinal health of canine. Furthermore, as dogs and humans exhibit high structural and functional similarities in their microbiome, and their IBD symptoms share similar features, this study may have the potential to extend to improving human gut health 18,19 …”

Section: Introductionmentioning

confidence: 97%

“…Furthermore, as dogs and humans exhibit high structural and functional similarities in their microbiome, and their IBD symptoms share similar features, this study may have the potential to extend to improving human gut health. 18,19 function on canine IBD is mediated by altering gut microbial composition and improving bile acid metabolism. This study proposes a natural polyphenol-based dietary strategy for improving canine intestinal health.…”

Section: Introductionmentioning

confidence: 99%

Grape seed proanthocyanidin improves intestinal inflammation in canine through regulating gut microbiota and bile acid compositions

Zhang,

Mo,

Wang

et al. 2023

The FASEB Journal

View full text Add to dashboard Cite

Although certain progress has been made in treating canine inflammatory bowel disease (IBD), a large proportion of dogs have a poor prognosis and may develop resistance and side effects. Therefore, it is of great significance to prevent or alleviate canine IBD through nutritional intervention. Plant polyphenol can interact with intestinal bacteria and has important prospects in the intestinal health improvement. This study evaluated the effect of grape seed proanthocyanidin (GSP), a plant‐derived natural polyphenol, on Labrador Retrievers with mild IBD. In Experiment 1 of this study, GSP alleviated persistent intestinal inflammation in canines by improving inflammatory indexes and reducing intestinal permeability. Moreover, GSP treatment increased the abundance of bacteria with potential anti‐inflammatory properties and engaging bile acid metabolism, including Ruminococcaceae, Faecalibacterium, Ruminococcus_torques_group, and Lachnospiraceae_NK4A136_group. Notably, targeted metabolomic analysis identified elevated productions of fecal chenodeoxycholic acid and its microbial transformation product lithocholic acid, which might contribute to relieving canine intestinal inflammation. Further, in Experiment 2, fecal microbiota transplantation was used to determine whether gut microbiota is a potential mechanism for GSP efficacy. Dogs with mild IBD received the fecal microbiota from the group administered GSP and mirrored the improvement effects of GSP, which results verified that gut microbial alteration could be an underlying mechanism for GSP efficiency on canine IBD. Our findings highlight that the mechanism of the GSP function on canine IBD is mediated by altering gut microbial composition and improving bile acid metabolism. This study proposes a natural polyphenol‐based dietary strategy for improving canine intestinal health.

show abstract

Inflammation-Associated Microbiota Composition Across Domestic Animals

Cited by 12 publications

References 84 publications

Metabolic Alternations During Gestation in Dezhou Donkeys and the Link to the Gut Microbiota

Metabolic Alternations During Gestation in Dezhou Donkeys and the Link to the Gut Microbiota

Gut Microbiome Signatures of Yorkshire Terrier Enteropathy during Disease and Remission

Grape seed proanthocyanidin improves intestinal inflammation in canine through regulating gut microbiota and bile acid compositions

Contact Info

Product

Resources

About