Inflammation—Cause or consequence of late onset Alzheimer’s disease or both? A review of the evidence

Zhao, Jinrong; Zhao, Dong; Wang, Jinpei; Luo, Xiaoe; Guo, Rui

doi:10.1177/1721727x221095383

Cited by 3 publications

(2 citation statements)

References 93 publications

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“…It is likely that neuroinflammation is both a response to Aβ and tau NFT that exacerbates their deleterious effects, and a cause of the disease, that increases brain deposit of Aβ and tau phosphorylation starting before onset of symptoms ( 73 , 74 ). Convincing new data in patients show that microglia activation and consequent neuroinflammation are associated with disease development and progression ( 75 ).…”

Section: Alzheimer’s Diseasementioning

confidence: 99%

Cause or consequence? The role of IL-1 family cytokines and receptors in neuroinflammatory and neurodegenerative diseases

et al. 2023

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Cytokines and receptors of the IL-1 family are key mediators in innate immune and inflammatory reactions in physiological defensive conditions, but are also significantly involved in immune-mediated inflammatory diseases. Here, we will address the role of cytokines of the IL-1 superfamily and their receptors in neuroinflammatory and neurodegenerative diseases, in particular Multiple Sclerosis and Alzheimer’s disease. Notably, several members of the IL-1 family are present in the brain as tissue-specific splice variants. Attention will be devoted to understanding whether these molecules are involved in the disease onset or are effectors of the downstream degenerative events. We will focus on the balance between the inflammatory cytokines IL-1β and IL-18 and inhibitory cytokines and receptors, in view of future therapeutic approaches.

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Section: Alzheimer’s Diseasementioning

confidence: 99%

Cause or consequence? The role of IL-1 family cytokines and receptors in neuroinflammatory and neurodegenerative diseases

et al. 2023

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“…Inflammation is involved in the development of AD, but it remains unclear if this is a cause or consequence, or vicious cycle involving both (Zhao et al, 2022). The aging process alone involves chronic low-grade inflammation as evidenced by elevated levels of C-reactive protein (CRP), and other proinflammatory cytokines such as tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6; Zhao et al, 2022). Inflammation is part of any disease process including the cascade involving the chronic stress response.…”

Section: Stigma and The Chronic Stress Responsementioning

confidence: 99%

The relationship between perceived stigma and perceived stress in cognitive decline: a survey of persons with mild cognitive impairment and their caregivers

Warren

2023

Front. Psychol.

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IntroductionWhile Alzheimer’s disease and other causes of dementia have rapidly become a global health crisis with growing incidence that is unabated, the incidence of Mild Cognitive Impairment (MCI) far exceeds that of Alzheimer’s disease. Persons with MCI demonstrate some level of cognitive impairment, but daily functions remain intact and there is no certainty that they will develop dementia. Yet, the possibility conjures a considerable amount of fear and anxiety, further fueled by a vast array of misconceptions and stigma. The pervasive nature of this stigma permeates society and culture at many levels. Persons with MCI who are at higher risk for development of dementia may be especially vulnerable to fear and stigma associated with the diagnosis. Based on this premise, the primary aim of this study was to examine the relationship between perceived stigma and perceived stress in persons with MCI and their care partners, including the relationship between income and the study variables. The secondary aim was to examine the effect of a combined cognitive rehabilitation and wellness program on these perceptions.MethodsThirty participants were recruited from Mayo Clinic’s Health Action to Benefit Independence and Thinking (HABIT) program. MCI (n = 15) and care partner (n = 15) participants completed the Stigma Impact Scale (SIS) and the Perceived Stress Scale (PSS) before and after the HABIT program.ResultsAverage SIS and PSS scores decreased in the MCI, care partner, and combined groups, both pre- and post-HABIT. Linear regression was used to assess the relationship between perceived stigma and stress, controlling for income. A significant relationship was found between perceived stigma and perceived stress both pre and post-HABIT.DiscussionThe results suggest a relationship exists between perceived stigma and perceived stress in persons with MCI and their care partners, and an educational program such as HABIT may strengthen this relationship by informing participants of potential challenges that occur in cognitive decline. Understanding these relationships may provide an opportunity to provide tools for this vulnerable population.

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Systemic inflammation in Aβ1-40-induced Alzheimer’s disease model: New translational opportunities

Nefodova,

Rudyk,

Dovhyi

et al. 2024

Brain Research

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Inflammation—Cause or consequence of late onset Alzheimer’s disease or both? A review of the evidence

Cited by 3 publications

References 93 publications

Cause or consequence? The role of IL-1 family cytokines and receptors in neuroinflammatory and neurodegenerative diseases

Cause or consequence? The role of IL-1 family cytokines and receptors in neuroinflammatory and neurodegenerative diseases

The relationship between perceived stigma and perceived stress in cognitive decline: a survey of persons with mild cognitive impairment and their caregivers

Systemic inflammation in Aβ1-40-induced Alzheimer’s disease model: New translational opportunities

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