Inflammation During Virus Infection: Swings and Roundabouts

Bhattacharyya, Sankar

doi:10.1007/978-981-15-1045-8_3

Cited by 11 publications

(16 citation statements)

References 184 publications

(135 reference statements)

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“…Although viruses can replicate in several cell types, the pathological outcome only appears in one or a few tissuespecific cells. 83 The primary encounter with the virus occurs in mononuclear phagocytic cells such as monocytes, macrophages, and dendritic cells. 83 The stimulation of the innate and adaptive immune system in response to viral infections destroys infected cells, inducing inflammation that may lead to severe pathological consequences for the host.…”

Section: Inflammatory Processes Caused By Viral Infectionsmentioning

confidence: 99%

“…83 The primary encounter with the virus occurs in mononuclear phagocytic cells such as monocytes, macrophages, and dendritic cells. 83 The stimulation of the innate and adaptive immune system in response to viral infections destroys infected cells, inducing inflammation that may lead to severe pathological consequences for the host. The damage of cells caused by the immune system with a viral infection is known as virus-induced inflammation.…”

Section: Inflammatory Processes Caused By Viral Infectionsmentioning

confidence: 99%

“…The damage of cells caused by the immune system with a viral infection is known as virus-induced inflammation. [83][84][85] In the earliest stages of viral infection, cytokines are produced when the innate immune defense is activated. 83,86,87 Neutrophils are among the earliest types of phagocytic cells entering the site of infection and are classic markers of the inflammation process.…”

Section: Inflammatory Processes Caused By Viral Infectionsmentioning

confidence: 99%

“…[83][84][85] In the earliest stages of viral infection, cytokines are produced when the innate immune defense is activated. 83,86,87 Neutrophils are among the earliest types of phagocytic cells entering the site of infection and are classic markers of the inflammation process. 83,86,87 The rapid release of cytokines at the site of infection initiates new reactions with far-reaching consequences, including inflammation.…”

Section: Inflammatory Processes Caused By Viral Infectionsmentioning

confidence: 99%

“…83,86,87 Neutrophils are among the earliest types of phagocytic cells entering the site of infection and are classic markers of the inflammation process. 83,86,87 The rapid release of cytokines at the site of infection initiates new reactions with far-reaching consequences, including inflammation. 83,86,87 One of the first cytokines to be produced is tumor necrosis factor alpha TNFα, which is synthesized by activated monocytes and macrophages.…”

Section: Inflammatory Processes Caused By Viral Infectionsmentioning

confidence: 99%

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Common Inflammatory Mechanisms in COVID-19 and Parkinson’s Diseases: The Role of Microbiome, Pharmabiotics and Postbiotics in Their Prevention

Даниленко¹,

Devyatkin²,

Марсова³

et al. 2021

JIR

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In the last decade, metagenomic studies have shown the key role of the gut microbiome in maintaining immune and neuroendocrine systems. Malfunction of the gut microbiome can induce inflammatory processes, oxidative stress, and cytokine storm. Dysfunction of the gut microbiome can be caused by short-term (virus infection and other infectious diseases) or long-term (environment, nutrition, and stress) factors. Here, we reviewed the inflammation and oxidative stress in neurodegenerative diseases and coronavirus infection (COVID-19). Here, we reviewed the renin-angiotensin-aldosterone system (RAAS) involved in the processes of formation of oxidative stress and inflammation in viral and neurodegenerative diseases. Moreover, the coronavirus uses ACE2 receptors of the RAAS to penetrate human cells. The coronavirus infection can be the trigger for neurodegenerative diseases by dysfunction of the RAAS. Pharmabiotics, postbiotics, and nextgeneration probiotics, are considered as a means to prevent oxidative stress, inflammatory processes, neurodegenerative and viral diseases through gut microbiome regulation.

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Section: Inflammatory Processes Caused By Viral Infectionsmentioning

confidence: 99%

Section: Inflammatory Processes Caused By Viral Infectionsmentioning

confidence: 99%

Section: Inflammatory Processes Caused By Viral Infectionsmentioning

confidence: 99%

Section: Inflammatory Processes Caused By Viral Infectionsmentioning

confidence: 99%

Section: Inflammatory Processes Caused By Viral Infectionsmentioning

confidence: 99%

See 3 more Smart Citations

Common Inflammatory Mechanisms in COVID-19 and Parkinson’s Diseases: The Role of Microbiome, Pharmabiotics and Postbiotics in Their Prevention

Даниленко¹,

Devyatkin²,

Марсова³

et al. 2021

JIR

View full text Add to dashboard Cite

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Regulatory role of miRNAs in the human immune and inflammatory response during the infection of SARS‐CoV‐2 and other respiratory viruses: A comprehensive review

Chakraborty,

Bhattacharya,

Lee

2024

Reviews in Medical Virology

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AbstractmiRNAs are single‐stranded ncRNAs that act as regulators of different human body processes. Several miRNAs have been noted to control the human immune and inflammatory response during severe acute respiratory infection syndrome (SARS‐CoV‐2) infection. Similarly, many miRNAs were upregulated and downregulated during different respiratory virus infections. Here, an attempt has been made to capture the regulatory role of miRNAs in the human immune and inflammatory response during the infection of SARS‐CoV‐2 and other respiratory viruses. Firstly, the role of miRNAs has been depicted in the human immune and inflammatory response during the infection of SARS‐CoV‐2. In this direction, several significant points have been discussed about SARS‐CoV‐2 infection, such as the role of miRNAs in human innate immune response; miRNAs and its regulation of granulocytes; the role of miRNAs in macrophage activation and polarisation; miRNAs and neutrophil extracellular trap formation; miRNA‐related inflammatory response; and miRNAs association in adaptive immunity. Secondly, the miRNAs landscape has been depicted during human respiratory virus infections such as human coronavirus, respiratory syncytial virus, influenza virus, rhinovirus, and human metapneumovirus. The article will provide more understanding of the miRNA‐controlled mechanism of the immune and inflammatory response during COVID‐19, which will help more therapeutics discoveries to fight against the future pandemic.

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Modulation of in Vitro SARS-CoV-2 Infection by Stephania tetrandra and Its Alkaloid Constituents

et al. 2023

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Botanical natural products have been widely consumed for their purported usefulness against COVID-19. Here, six botanical species from multiple sources and 173 isolated natural product compounds were screened for blockade of wild-type (WT) SARS-CoV-2 infection in human 293T epithelial cells overexpressing ACE-2 and TMPRSS2 protease (293TAT). Antiviral activity was demonstrated by an extract from Stephania tetrandra . Extract fractionation, liquid chromatography–mass spectrometry (LC-MS), antiviral assays, and computational analyses revealed that the alkaloid fraction and purified alkaloids tetrandrine, fangchinoline, and cepharanthine inhibited WT SARS-CoV-2 infection. The alkaloids and alkaloid fraction also inhibited the delta variant of concern but not WT SARS-CoV-2 in VeroAT cells. Membrane permeability assays demonstrate that the alkaloids are biologically available, although fangchinoline showed lower permeability than tetrandrine. At high concentrations, the extract, alkaloid fractions, and pure alkaloids induced phospholipidosis in 293TAT cells and less so in VeroAT cells. Gene expression profiling during virus infection suggested that alkaloid fraction and tetrandrine displayed similar effects on cellular gene expression and pathways, while fangchinoline showed distinct effects on cells. Our study demonstrates a multifaceted approach to systematically investigate the diverse activities conferred by complex botanical mixtures, their cell-context specificity, and their pleiotropic effects on biological systems.

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Inflammation During Virus Infection: Swings and Roundabouts

Abstract: 44 KeywordsInflammation · RNA virus · Cytokine therapy 3.1

Cited by 11 publications

References 184 publications

Common Inflammatory Mechanisms in COVID-19 and Parkinson’s Diseases: The Role of Microbiome, Pharmabiotics and Postbiotics in Their Prevention

Common Inflammatory Mechanisms in COVID-19 and Parkinson’s Diseases: The Role of Microbiome, Pharmabiotics and Postbiotics in Their Prevention

Regulatory role of miRNAs in the human immune and inflammatory response during the infection of SARS‐CoV‐2 and other respiratory viruses: A comprehensive review

Modulation of in Vitro SARS-CoV-2 Infection by Stephania tetrandra and Its Alkaloid Constituents

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