2004
DOI: 10.1161/01.str.0000106481.59944.2f
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Inflammation, Homocysteine, and Vitamin B6 Status After Ischemic Stroke

Abstract: Background and Purpose-Epidemiological studies have described an association between low vitamin B6 (measured as pyridoxal 5Ј-phosphate [PLP]) and ischemic stroke, independent of homocysteine (tHcy). We investigated B6 status, tHcy, and inflammation (measured by C-reactive protein [CRP]) in patients with stroke and controls. Methods-Consecutive cases with new ischemic stroke were compared with matched controls. Fasting tHcy, PLP, and CRP were measured. Results-The adjusted odds ratio of low PLP in the highest … Show more

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Cited by 79 publications
(52 citation statements)
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“…This finding supports those from studies of vitamin B 6 -deficient monkeys and epidemiological studies (Rimm et al 1998) in which an association between low vitamin B 6 status and vascular disease has been reported, which might be explained by a relationship between inflammation and low vitamin B 6 status that has been reported by Kelly et al (2004). Whatever the mechanism, such associations between Bvitamin status and vascular disease suggest that tHcy might be an indicator of low B-vitamin status rather than being directly related to disease.…”
Section: Vitamin Bsupporting
confidence: 89%
“…This finding supports those from studies of vitamin B 6 -deficient monkeys and epidemiological studies (Rimm et al 1998) in which an association between low vitamin B 6 status and vascular disease has been reported, which might be explained by a relationship between inflammation and low vitamin B 6 status that has been reported by Kelly et al (2004). Whatever the mechanism, such associations between Bvitamin status and vascular disease suggest that tHcy might be an indicator of low B-vitamin status rather than being directly related to disease.…”
Section: Vitamin Bsupporting
confidence: 89%
“…NS, not significant. of a link between inflammation and vitamin B 6 not only in patients affected by inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease (19,26 ), but also in stroke patients and in controls (27 ). Moreover, our findings are at variance with those observed in a subset of the ARIC study, in which leukocyte count but not CRP was a correlate of serum vitamin B 6 (28 ).…”
Section: Discussioncontrasting
confidence: 60%
“…A possible explanation might be that the use and turnover of plasma PLP increased or redistributed PLP from plasma to erythrocyte in an acute systemic inflammatory response (Talwar et al, 2003;Gray et al, 2004;Quasim et al, 2005); plasma PLP, therefore, was negatively associated with CRP level in our earlier study, which included critically ill patients (Huang et al, 2005), and in other studies (Friso et al, 2001(Friso et al, , 2004Kelly et al, 2004). However, RA is a chronic rather than acute inflammatory disease; our RA patients had not only adequate but also relatively high plasma PLP concentrations before the intervention (week 0).…”
Section: Discussionmentioning
confidence: 62%