Inflammation in multimorbidity and disability: An integrative review.

Friedman, Elliot; Shorey, Carrie

doi:10.1037/hea0000749

Cited by 48 publications

(40 citation statements)

References 123 publications

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“…Equally important to a healthy diet, physical activity has the potential to improve inflammatory status and mobility in chronic stroke patients [ 69 ]. Inflammation is common in several chronic diseases [ 70 ]. It shows an association with malnutrition, functional outcomes [ 71 ], and disability [ 72 ].…”

Section: Discussionmentioning

confidence: 99%

Physical Activity and Diet Quality Modify the Association between Comorbidity and Disability among Stroke Patients

Nguyen

Binh

et al. 2021

Nutrients

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Background: Comorbidity is common and causes poor stroke outcomes. We aimed to examine the modifying impacts of physical activity (PA) and diet quality on the association between comorbidity and disability in stroke patients. Methods: A cross-sectional study was conducted on 951 stable stroke patients in Vietnam from December 2019 to December 2020. The survey questionnaires were administered to assess patients’ characteristics, clinical parameters (e.g., Charlson Comorbidity Index items), health-related behaviors (e.g., PA using the International Physical Activity Questionnaire- short version), health literacy, diet quality (using the Dietary Approaches to Stop Hypertension Quality (DASH-Q) questionnaire), and disability (using the World Health Organization Disability Assessment Schedule II (WHODAS II)). Linear regression models were used to analyze the associations and interactions. Results: The proportion of comorbidity was 49.9% (475/951). The scores of DASH-Q and WHODAS II were 29.2 ± 11.8, 32.3 ± 13.5, respectively. Patients with comorbidity had a higher score of disability (regression coefficient, B, 8.24; 95% confidence interval, 95%CI, 6.66, 9.83; p < 0.001) as compared with those without comorbidity. Patients with comorbidity and higher tertiles of PA (B, −4.65 to −5.48; p < 0.05), and a higher DASH-Q score (B, −0.32; p < 0.001) had a lower disability score, as compared with those without comorbidity and the lowest tertile of PA, and the lowest score of DASH-Q, respectively. Conclusions: Physical activity and diet quality significantly modified the negative impact of comorbidity on disability in stroke patients. Strategic approaches are required to promote physical activity and healthy diet which further improve stroke rehabilitation outcomes.

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Section: Discussionmentioning

confidence: 99%

Physical Activity and Diet Quality Modify the Association between Comorbidity and Disability among Stroke Patients

Nguyen

Binh

et al. 2021

Nutrients

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“…On the one hand, age-related frailty was an important factor in physical disability and mortality [ 8 , 24 , 25 ]. Complex interactions such as muscle strength decline [ 24 ], inflammation [ 26 ], neurological disorder [ 27 ] and chronic diseases [ 28 ] in the elderly lead to disability, and these risk factors were also accelerating the occurrence of death [ 24 ]. On the other hand, multi-morbidity was inextricably linked to death and disability in older adults [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Disability and the risk of subsequent mortality in elderly: a 12-year longitudinal population-based study

Yang

Liu

et al. 2021

BMC Geriatr

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Background Assessment the impact of disability on mortality among the elderly is vital to healthy ageing. The present study aimed to assess the long-term influence of disability on death in the elderly based on a longitudinal study. Method This study used the Chinese Longitudinal Healthy Longevity Study (CLHLS) data from 2002 to 2014, including 13,666 participants aged 65 years and older in analyses. The Katz ADL index was used to assess disability status and levels. Cumulative mortality rates were estimated by the Kaplan-Meier method. Cox proportional hazards models were conducted to estimate associations between disability and all-cause mortality for overall participants, two age groups as well as specific chronic disease groups. All reported results were adjusted by survey weights to account for the complex survey design. Results During the 12-year follow-up, the death density was 6.01 per 100 person-years. The 3-years’ cumulative mortality rate of nondisabled elderly was 11.9% (95%CI: 10.9, 12.9%). As the level of disability increased, the cumulative mortality rate was from 28.1% (95%CI: 23.0, 33.1%) to 77.6% (95%CI: 63.8, 91.4%). Compared with non-disabled elderly, the multiple-adjusted hazard ratio of death due to disability was 1.68 (95% CI: 1.48, 1.90). The hazard ratios varied from 1.44 (95%CI: 1.23, 1.67) to 4.45 (95%CI: 2.69, 7.38) after classifying the disability levels. The hazard ratios of death in the young-old group (65–79 years) were higher than the old-old group (80 years and over) in both level B (HR = 1.58, 95%CI: 1.25, 2.00 vs. HR = 1.22, 95%CI: 1.06, 1.39, P = 0.029) and level G (HR = 24.09, 95%CI: 10.83, 53.60 vs. HR = 2.56, 95%CI: 1.75, 3.74, P < 0.001). For patients with hypertension, diabetes, heart disease, cerebrovascular disease as well as dementia, disability increases their relative risk of mortality by 1.64 (95%CI: 1.40, 1.93), 2.85 (95%CI: 1.46, 5.58), 1.45 (95%CI: 1.02, 2.05), 2.13 (95%CI: 1.54, 2.93) and 3.56 (95%CI: 1.22, 10.38) times, respectively. Conclusions Disability increases the risk of all-cause death in the elderly, especially those with chronic diseases and the young-old group. Further studies are needed to better understand how to effectively prevent disability in the older population.

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“…A study in the Brazilian city of Manaus in 2015 found a higher dengue rate in the previous year in persons with multimorbidity 25 . Although the knowledge is still incipient on the biological mechanism that increases the risk of infections among persons with multimorbidity, the mechanism appears to be associated with increased inflammation and the body's decreased immune response capacity 26,27,28 . Nevertheless, it essential to understand this process in greater detail, considering the identification of differences according to morbidity patterns 29 .…”

Section: Discussionmentioning

confidence: 99%

Multimorbidade e população em risco para COVID-19 grave no Estudo Longitudinal da Saúde dos Idosos Brasileiros

et al. 2020

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O objetivo deste trabalho foi medir a ocorrência de multimorbidade e estimar o número de indivíduos na população brasileira com 50 anos ou mais em risco para COVID-19 grave. Estudo transversal de base nacional com dados do Estudo Longitudinal da Saúde dos Idosos Brasileiros (ELSI-Brasil), conduzido em 2015-2016, com 9.412 indivíduos com 50 anos ou mais. A multimorbidade foi caracterizada como ≥ 2 condições crônicas com base em uma lista de 15 morbidades consideradas de risco para COVID-19 grave. As análises incluíram cálculo de prevalência e estimativa do número absoluto de pessoas na população em risco. Autoavaliação do estado de saúde, fragilidade e atividades básicas da vida diária foram utilizadas como marcadores da situação de saúde. Sexo, idade, região geopolítica e escolaridade foram usados como covariáveis. Cerca de 80% dos indivíduos da amostra apresentaram pelo menos alguma das morbidades avaliadas, o que representa cerca de 34 milhões de indivíduos; a multimorbidade foi referida por 52% da população em estudo, com maior proporção nas regiões Centro-oeste, Sudeste e Sul. Doenças cardiovasculares e obesidade foram as condições crônicas mais frequentes. Estima-se que 2,4 milhões de brasileiros estejam em risco grave de saúde. Desigualdades segundo a escolaridade foram observadas. O número de pessoas com 50 anos ou mais que apresentam morbidades de risco para COVID-19 grave é elevado tanto em termos relativos quanto absolutos. A estimativa apresentada é importante para planejar as estratégias de monitoramento das pessoas com morbidades crônicas e de prevenção no enfrentamento do novo coronavírus.

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Inflammation in multimorbidity and disability: An integrative review.

Cited by 48 publications

References 123 publications

Physical Activity and Diet Quality Modify the Association between Comorbidity and Disability among Stroke Patients

Physical Activity and Diet Quality Modify the Association between Comorbidity and Disability among Stroke Patients

Disability and the risk of subsequent mortality in elderly: a 12-year longitudinal population-based study

Multimorbidade e população em risco para COVID-19 grave no Estudo Longitudinal da Saúde dos Idosos Brasileiros

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