Inflammation-induced motivational changes: perspective gained by evaluating positive and negative valence systems

Vichaya, Elisabeth G.; Dantzer, Robert

doi:10.1016/j.cobeha.2018.01.008

Cited by 29 publications

(16 citation statements)

References 55 publications

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“…Animal studies indicate that effort expenditure is influenced by inflammation (104–106). In general, inflammation increases averseness toward negative stimuli and positive stimuli (107). Animal models of motivation indicate that both approach and avoidance motivation are affected by pro-inflammatory cytokines.…”

Section: Inflammationmentioning

confidence: 99%

Fatigue, Sleep, and Autoimmune and Related Disorders

2019

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Profound and debilitating fatigue is the most common complaint reported among individuals with autoimmune disease, such as systemic lupus erythematosus, multiple sclerosis, type 1 diabetes, celiac disease, chronic fatigue syndrome, and rheumatoid arthritis. Fatigue is multi-faceted and broadly defined, which makes understanding the cause of its manifestations especially difficult in conditions with diverse pathology including autoimmune diseases. In general, fatigue is defined by debilitating periods of exhaustion that interfere with normal activities. The severity and duration of fatigue episodes vary, but fatigue can cause difficulty for even simple tasks like climbing stairs or crossing the room. The exact mechanisms of fatigue are not well-understood, perhaps due to its broad definition. Nevertheless, physiological processes known to play a role in fatigue include oxygen/nutrient supply, metabolism, mood, motivation, and sleepiness—all which are affected by inflammation. Additionally, an important contributing element to fatigue is the central nervous system—a region impacted either directly or indirectly in numerous autoimmune and related disorders. This review describes how inflammation and the central nervous system contribute to fatigue and suggests potential mechanisms involved in fatigue that are likely exhibited in autoimmune and related diseases.

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Section: Inflammationmentioning

confidence: 99%

Fatigue, Sleep, and Autoimmune and Related Disorders

2019

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“…CNS also affects peripheral immune activation. [65,66] Bidirectional signaling pathways exist between the immune and nervous systems both at peripheral and central levels. [58,61,65,[67][68][69] The CNS exerts top-down effects on peripheral inflammatory activity via neuroendocrine and autonomic effector mechanisms.…”

Section: Why Is the Protein Pattern In Plasma Important For Ppt?mentioning

confidence: 99%

Plasma protein patterns are strongly correlated with pressure pain thresholds in women with chronic widespread pain and in healthy controls—an exploratory case-control study

Gerdle¹,

Wåhlén²,

Ghafouri³

2020

Medicine

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Chronic widespread pain (CWP) is a complex pain condition characterized by generalized musculoskeletal pain and often associated with other symptoms. An important clinical feature is widespread increased pain sensitivity such as lowered pain thresholds for mechanical stimuli (pressure pain thresholds [PPT]). There is a growing interest in investigating the activated neurobiological mechanisms in CWP, which includes fibromyalgia. In CWP, strong significant correlations have been found between muscle protein patterns and PPT. This explorative proteomic study investigates the multivariate correlation pattern between plasma proteins and PPT in CWP and in healthy controls (CON). In addition, this study analyses whether the important proteins for PPT differ between the 2 groups.Using 2-dimensional gel electrophoresis, we analyzed the plasma proteome of the CWP (n = 15) and the CON (n = 23) and proteins were identified using mass spectrometry. For both the CWP and the CON, the associations between the identified proteins and PPT were analyzed using orthogonal partial least square in 2 steps.Significant associations between certain plasma proteins and PPT existed both in CWP (R 2 = 0.95; P = .006) and in CON (R 2 = 0.89; P < .001). For both groups of subjects, we found several proteins involved in PPT that reflect different biological processes. The plasma proteins as well as the biological processes involved in PPT differed markedly between the 2 groups of subjects.This study suggests that plasma protein patterns are associated with pain thresholds in CWP. Using the plasma proteome profile of CWP to study potential biomarker candidates could provide a snapshot of ongoing systemic mechanisms in CWP.Abbreviations: 2-DE = two-dimensional gel electrophoresis, CNS = central nervous system, CON = healthy controls, CV-ANOVA = ANOVA of the cross-validated residuals, CWP = chronic widespread pain, FDR = false discovery rate, FM = fibromyalgia, HADS = hospital anxiety and depression scale, MS = mass spectrometry, MVDA = advanced multivariate analysis, OPLS = orthogonal partial least square regression, PPI = protein-protein interaction, PPT = pressure pain threshold, STRING = search tool for retrieval of interacting genes/proteins, VIP = variable influence on projection.

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“…In addition, immune or behavioral manipulations performed at stages of development that range from the perinatal period, adolescence, and adulthood until senescence, indicate that the impact of behavior–immune interactions is age‐ and sex‐dependent. It is beyond the scope of this article to review the extremely abundant literature dealing with one or the other aspect of this broad subject, and only a few articles from the many available are mentioned here . These reviews also include a large list of references to which the reader interested in a given aspect is referred to.…”

Section: Immunity and Behaviormentioning

confidence: 99%

Immunity and ultrasonic vocalization in rodents

Jouda

Wöhr

Rey

2018

Annals of the New York Academy of Sciences

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Ultrasonic vocalizations (USVs) serve important communicative functions in rodents. Different types of USVs can be triggered in the sender, for example, by maternal separation, social interactions, or exposure to predators, and they evoke affiliative or alarming behaviors in recipients. This review focusses on studies evaluating possible links between immunity and USVs. Most studies have been performed in a murine model of maternal immune activation and subsequent evaluation of effects in the offspring. This model has received large attention in recent years because it mimics behavioral abnormalities observed in certain human neuropsychiatric disorders, including autism spectrum disorder. Although there is still some controversy, the results indicate that stimulation of the immune system of mice and rats during pregnancy affects ultrasonic calling in pups. Few studies are available on immunization during adulthood and USVs. In most cases, immune stimulation led to disease, complicating conclusions about a possible direct link between vocalization and immunity. Although much work is still needed, this is certainly a rather new and promising aspect of interactions between the immune system and behavior.

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Inflammation-induced motivational changes: perspective gained by evaluating positive and negative valence systems

Cited by 29 publications

References 55 publications

Fatigue, Sleep, and Autoimmune and Related Disorders

Fatigue, Sleep, and Autoimmune and Related Disorders

Plasma protein patterns are strongly correlated with pressure pain thresholds in women with chronic widespread pain and in healthy controls—an exploratory case-control study

Immunity and ultrasonic vocalization in rodents

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