Inflammation-related indicators to distinguish between gastric stromal tumors and leiomyomas: A retrospective study

Zhai, Yuhao; Zheng, Zhi; Deng, Wei; Yin, Jie; Bai, Zhigang; Liu, Xiaoye; Zhang, Jun; Zhang, Zhong-Tao

doi:10.12998/wjcc.v10.i2.458

Cited by 6 publications

(7 citation statements)

References 22 publications

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“…A clinical study [ 20 ] also showed that PLR is an independent risk factor for postoperative metastasis of malignant tumors, and a high PLR indicates a higher rate of postoperative metastasis. Several differential diagnosis studies [ 14 , 21 ] have shown that PLR is an important index for establishing a predictive model for the diagnosis of leiomyoma. The NLR indicates the ratio of neutrophils to lymphocytes; importantly, it is an established index of inflammation and a prognostic index for many diseases [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Correlation Between Platelet-Lymphocyte Ratio and Neutrophil-Lymphocyte Ratio in Patients with Uterine Leiomyoma: A Cross-Sectional Study

Duan

Peng

Shi

et al. 2022

Journal of Oncology

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The inflammatory reaction has been proven to be a key factor in the pathogenesis of uterine leiomyoma. The platelet-lymphocyte ratio (PLR) and the neutrophil-lymphocyte ratio (NLR) are inexpensive and reliable inflammatory biomarkers. However, evidence of the relationship between PLR and NLR in patients with uterine leiomyoma is limited. This study aimed to explore the relationship between PLR and NLR in patients with incident uterine leiomyoma. This cross-sectional study included 763 patients with uterine leiomyoma who were first diagnosed in our hospital between January 2016 and December 2016. Patient characteristics were collected for univariate analysis, smooth curve fitting, and multivariate piecewise linear regression. Overall, 722 patients with an average age of 40.16 ± 5.99 years were included. The average PLR was 161.22 ± 65.33. Univariate analysis revealed a significant positive correlation between PLR and NLR ( P < 0.0001 ). In addition, the non-linear relationship between the PLR and NLR was tested using smooth curve fitting after adjusting for potential confounding factors. The multivariate piecewise linear regression model showed that there was a significant positive correlation between PLR and NLR in both PLR <226.45 (β 0.01, 95% CI: 0.01, 0.01; P < 0.0001 ) and >226.45 (β 0.00, 95% CI: 0.00, 0.00; P = 0.0026 ). In conclusion, PLR and NLR are positively correlated in patients with uterine leiomyoma. This result clarifies the promoting role of inflammation in the occurrence of uterine leiomyoma.

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Section: Discussionmentioning

confidence: 99%

Correlation Between Platelet-Lymphocyte Ratio and Neutrophil-Lymphocyte Ratio in Patients with Uterine Leiomyoma: A Cross-Sectional Study

Duan

Peng

Shi

et al. 2022

Journal of Oncology

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“…Fibroid is one of the most common gynecologic conditions, but it does not occur before puberty and its frequency decreases with menopause (1,2). They are diagnosed in 20%-25% of women of reproductive age and in 30%-40% of women older than 40 years (3)(4)(5). They originate from the clonal expansion of a smooth muscle cell stimulated by estrogen and progesterone (6,7).…”

Section: Introductionmentioning

confidence: 99%

Transvaginal natural orifice endoscopic surgery for myomectomy: Can it be a conventional surgery?

Hou

Li²,

Huang³

et al. 2022

Front. Surg.

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IntroductionAs a new minimally invasive surgery, transvaginal natural orifice transluminal endoscopic surgery (vNOTES) has been proved to be suitable for the treatment of a variety of gynecological benign diseases. However, compared with other minimally invasive surgeries that have been widely used, such as conventional multiport laparoscopy and transumbilical laparoendoscopic single-site surgery (LESS), their advantages and disadvantages and how to choose are still unknown. The purpose of our study is to compare the advantages and disadvantages of the three minimally invasive surgeries in myomectomy and to provide theoretical basis for the wider development of vNOTES surgery.Material and methodsThis retrospective study included 282 patients at our hospital who underwent laparoscopic myomectomy from May 2021 to March 2022. Based on the surgical approach, patients were classified into multiport, transumbilical LESS, and vNOTES groups. The patients’ demographic characteristics and follow-up data were collected during the perioperative period and at 1 month postoperatively.ResultsAmong the three procedures, vNOTES had the shortest anal exhaust time but also the highest postoperative infection rate. Multiple linear regression analysis showed that the operative time increased by 3.5 min for each 1 cm increase in myoma, and intraoperative bleeding increased by approximately 12 ml. The average duration of single pores increased by 25 min compared to that of multiports, and the operative duration increased by 10.48 min for each degree of adhesion.ConclusionsFor gynecologists who have mastered vNOTES, this procedure has the same efficacy and safety as the two existing minimally invasive surgeries in myomectomy, but it shows obvious advantages in postoperative recovery.

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“…[44] These findings suggested that changes in SII values may indicate tumor progression. [45,46] Another retrospective study by Gao et al involving 400 NSCLC patients showed that high SII was significantly associated with advanced T-stage and positive lymph node metastasis. [47,48] Similarly, Tomita et al conducted a study on 471 NSCLC patients and found that low SII was significantly associated with the lower pathological TNM stage.…”

Section: Platelets and Non-small Cell Lung Cancermentioning

confidence: 99%

“…[ 44 ] These findings suggested that changes in SII values may indicate tumor progression. [ 45 , 46 ]…”

Section: The Relationship Between Tumors and Inflammationmentioning

confidence: 99%

“…Xu et al conducted a study involving 234 patients with pathologically confirmed bone metastases from non-small cell lung cancer (NSCLC). [ 46 ] They found a significant association between pretreatment SII values and the number of distant metastases. Patients with higher SII values had a higher number of distant metastases, indicating a potential role of SII in predicting metastatic spread.…”

Section: The Relationship Between Tumors and Inflammationmentioning

confidence: 99%

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Advances in systemic immune inflammatory indices in non-small cell lung cancer: A review

Mao,

Cao,

et al. 2024

Medicine

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Lung cancer is one of the most prevalent cancers globally, with non-small cell lung cancers constituting the majority. These cancers have a high incidence and mortality rate. In recent years, a growing body of research has demonstrated the intricate link between inflammation and cancer, highlighting that inflammation and cancer are inextricably linked and that inflammation plays a pivotal role in cancer development, progression, and prognosis of cancer. The Systemic Immunoinflammatory Index (SII), comprising neutrophil, lymphocyte, and platelet counts, is a more comprehensive indicator of the host’s systemic inflammation and immune status than a single inflammatory index. It is widely used in clinical practice due to its cost-effectiveness, simplicity, noninvasiveness, and ease of acquisition. This paper reviews the impact of SII on the development, progression, and prognosis of non-small cell lung cancer.

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Inflammation-related indicators to distinguish between gastric stromal tumors and leiomyomas: A retrospective study

Cited by 6 publications

References 22 publications

Correlation Between Platelet-Lymphocyte Ratio and Neutrophil-Lymphocyte Ratio in Patients with Uterine Leiomyoma: A Cross-Sectional Study

Correlation Between Platelet-Lymphocyte Ratio and Neutrophil-Lymphocyte Ratio in Patients with Uterine Leiomyoma: A Cross-Sectional Study

Transvaginal natural orifice endoscopic surgery for myomectomy: Can it be a conventional surgery?

Advances in systemic immune inflammatory indices in non-small cell lung cancer: A review

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