Inflammatory bowel disease: dysfunction of GALT and gut bacterial flora (II)

Chandran, P.; Satthaporn, Sukchai; Robins, Adrian; Eremin, O.

doi:10.1016/s1479-666x(03)80091-4

Cited by 51 publications

(35 citation statements)

References 91 publications

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“…Inflammatory bowel disease is a severe form of intestinal inflammation with unclear pathogenesis resulting in part from complex mucosal immune responses to resident enteric bacteria [6,7]. Bacterial antigens are recognized through an extensive family of pattern recognition receptors [8,9].…”

Section: Discussionmentioning

confidence: 99%

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Bifidobacterium longum HY8004 attenuates TNBS-induced colitis by inhibiting lipid peroxidation in mice

et al. 2009

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Section: Discussionmentioning

confidence: 99%

“…IBD occurs most frequently in the terminal ileum and colon, where many intestinal microbes reside [6]. IBD does not significantly develop or progress in germ-free animals, indicating that intestinal microflora may play an important role in initiating and perpetuating colonic inflammation.…”

Section: Introductionmentioning

confidence: 99%

Bifidobacterium longum HY8004 attenuates TNBS-induced colitis by inhibiting lipid peroxidation in mice

et al. 2009

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“…UC occurs in the colon where many intestinal microbes reside [5,6] ; it does not significantly develop or progress in germ-free animals, which indicates that intestinal microflora play an important role in initiating and perpetuating colonic inflammation. Normal intestinal microflora comprises an estimated 400 different bacterial species that reach their highest concentrations in the terminal ileum and colon [7,8] .…”

Section: Introductionmentioning

confidence: 99%

Effect of probiotics on pro-inflammatory cytokines and NF-κB activation in ulcerative colitis

Hegazy

El-Bedewy²

2010

WJG

237

128

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AIM:To demonstrate the therapeutic effect of probiotics in patients with ulcerative colitis (UC), and their effect on inflammatory mediators and nuclear factor (NF)-κB activation in these patients. METHODS:Thirty patients with mild to moderate UC were randomly classified into two groups: sulfasalazine group, who received sulfasalazine 2400 mg/d; and probiotic group, who received sulfasalazine 2400 mg/d with probiotic. The patients were investigated before and after 8 wk of treatment with probiotic (Lactobacillus delbruekii and Lactobacillus fermentum ). Colonic activity of myeloperoxidase (MPO) was assayed with UV spectrophotometry, the colonic content of interleukin (IL)-6 was determined by enzyme-linked immunosorbent assay (ELISA), fecal calprotectin was determined by ELISA, and expression of NF-κB p65 and tumor necrosis factor (TNF)-α proteins in colonic tissue was identified by immunohistochemistry and reverse transcription polymerase chain reaction, respectively. RESULTS:At the start of the study, colonic mucosal injury and inflammation were demonstrated in UC patients by hematoxylin and eosin staining, and an increase in colonic MPO activity, fecal calprotectin, and expression of colonic TNF-α and NF-κB p65 proteins. The use of probiotic for 8 wk significantly ameliorated the inflammation by decreasing the colonic concentration of IL-6, expression of TNF-α and NF-κB p65, leukocyte recruitment, as demonstrated by a decrease in colonic MPO activity, and the level of fecal calprotectin compared to sulfasalazine group and the control group (P < 0.05). CONCLUSION:Oral supplementation with probiotics could be helpful in maintaining remission and preventing relapse of UC.

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“…An abnormal response of the body immune system to normal intestinal flora plays a major role in the pathogenesis of UC, which involves the entire immune response ( Thompson-Chagoyán et al, 2005). Multidrug resistant (MDR1a) genes are expressed on both immune and non-immune cell surfaces and have multiple functions (Chandran et al, 2003). Dommels et al (2007), using FVB wild-type and FVB multi-drug resistance gene knockout (MDR1a -/-) mice, observed P-gp in colitis and determined the humoral and cellular immune function in a UC group and non-UC group of MDR1a -/-mice.…”

Section: Introductionmentioning

confidence: 99%

Multidrug resistance gene and its relationship to ulcerative colitis and immune status of ulcerative colitis

Zhang

Wang

et al. 2014

Genet. Mol. Res.

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ABSTRACT. We examined the relationship among the multidrug resistance (MDR1) gene product P-glycoprotein (P-gp), ulcerative colitis, and immune status under ulcerative colitis. MDR1 P-gp expression and interleukin-8 levels in ulcerative colitis were determined using immunohistochemistry and a double-antibody sandwich avidinbiotin complex-enzyme-linked immunosorbent assay, respectively. Nitric oxide content and nitric oxide synthase activity in the colonic mucosa were determined using a colorimetric method; CD4 + and CD25 + T cell subset percentages in the peripheral blood were determined by flow cytometry. The positive expression rate of P-gp in patients with ulcerative colitis (17.4%) was significantly lower than that in the control group (31.4%). The expression rate decreased to 10.1, 9.2, and 8.3% after 12, 18, and 24 months of treatment, respectively, which were significantly lower than the expression rate before treatment (17.4%). P-gp expression levels during the remission phase and active phase of ulcerative colitis were 15.2 and 17.1%, respectively, which were significantly lower than that in normal controls (31.4%). Compared with P-gp-negative patients, nitric oxide content, nitric oxide synthase activity, and interleukin-8 levels were significantly higher in P-gppositive patients with moderately active, severely active, early onset, chronic relapsing, chronic persistent, and acute fulminant ulcerative colitis. CD4 + and CD25 + T cell subsets were significantly lower in the peripheral blood of patients with severely active and acute fulminant ulcerative colitis than in control subjects. Expression of the multidrug resistance gene and its product P-gp was observed in normal colon tissues and may be closely related to ulcerative colitis.

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Inflammatory bowel disease: dysfunction of GALT and gut bacterial flora (II)

Cited by 51 publications

References 91 publications

Bifidobacterium longum HY8004 attenuates TNBS-induced colitis by inhibiting lipid peroxidation in mice

Bifidobacterium longum HY8004 attenuates TNBS-induced colitis by inhibiting lipid peroxidation in mice

Effect of probiotics on pro-inflammatory cytokines and NF-κB activation in ulcerative colitis

Multidrug resistance gene and its relationship to ulcerative colitis and immune status of ulcerative colitis

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