Inflammatory bowel disease in ankylosing spondylitis

Jayson, M. I. V.; Salmon, P. R.; Harrison, Wendi

doi:10.1136/gut.11.6.506

Cited by 44 publications

(9 citation statements)

References 22 publications

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“…The large majority of the patients suffered from CD (76 %) and not UC. This is in contrast with results from previously published data (Jayson and Bouchier, 1968;Jayson et al, 1970;Brewerton et al, 1973), and also from our own data and the recent observation by Woodrow that UC patients possess HLA B27 more frequently than patients suffering from CD (J. C. Woodrow et al, unpublished). However, we have no reason to believe that the CD preponderance has occurred by a selection bias.…”

Section: Discussioncontrasting

confidence: 99%

“…It is well known that the incidence of inflammatory bowel disease (IBD) is increased in patients suffering from ankylosing spondylitis (AS) (Romanus, 1953;Steinberg and Story, 1957;Wilkinson and Bywaters, 1958;McBride et al, 1963;Jayson and Bouchier, 1968;Jayson et al, 1970;Meuwissen et al, 1978). On the other hand, there is an increased frequency of AS in IBD (Acheson, 1960;Moll et al, 1974;Dekker-Saeys, 1977).…”

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confidence: 99%

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Ankylosing spondylitis and inflammatory bowel disease. III. Clinical characteristics and results of histocompatibility typing (HLA B27) in 50 patients with both ankylosing spondylitis and inflammatory bowel disease.

Dekker-Saeys¹,

Meuwissen²,

Berg‐Loonen³

et al. 1978

Annals of the Rheumatic Diseases

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SUMMARY A study was made, in co-operation with several gastroenterology and rheumatology centres, of the clinical and genetic characteristics (HLA B27) of 50 patients suffering from both inflammatory bowel disease (38 Crohn's disease (CD), 12 ulcerated colitis (UC)) and ankylosing spondylitis (AS), the latter diagnosis being established according to the New York criteria. 20 CD (52 -6 %O) and 8 UC (66 * 7 %) patients were HLA B27 positive. The presence of HLA B27 was studied in relation to clinical parameters, such as first occurrence of symptoms of AS or inflammatory bowel disease (IBD), a history of peripheral arthritis, iridocyclitis, and a positive history of AS or IBD.Our patients were found to have heterogeneous clinical features: on one side of the spectrum a group of cases was distinguished with the typical characteristics of idiopathic AS, often being HLA B27 positive. On the other side a smaller group of HLA B27 negative patients was observed, with severe intestinal inflammatory pathology, lacking most of the typical clinical features of idiopathic AS ('secondary' form of AS). Finally, between these two extremes a group of patients was found with less pronounced clinical or genetic characteristics. These different clinical and histocompatibility patterns suggest a mixed aetiopathogenesis of AS in IBD patients. Such a 'syndrome' of AS might harbour both idiopathic AS and forms of AS 'secondary' to the intestinal inflammatory pathology.

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Section: Discussioncontrasting

confidence: 99%

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confidence: 99%

Ankylosing spondylitis and inflammatory bowel disease. III. Clinical characteristics and results of histocompatibility typing (HLA B27) in 50 patients with both ankylosing spondylitis and inflammatory bowel disease.

Dekker-Saeys¹,

Meuwissen²,

Berg‐Loonen³

et al. 1978

Annals of the Rheumatic Diseases

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“…Так, в 1970 г. были опубликованы результаты исследования M. Jayson и соавт. [14], которые оценили частоту поражения дистальных отделов ЖКТ у 47 больных достоверным (по Римским критериям) АС. В ходе эндоскопического исследования у 8 (17%) больных были выявлены четкие признаки ЯК, причем у трех паци-ентов -при полном отсутствии каких-либо симптомов, указывающих на патологию ЖКТ.…”

Section: таблицаunclassified

Bowel Involvement in Patients With Spondyloarthritis

Каратеев¹,

Галушко²

2015

rsp

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“…Numerous studies have demonstrated that there is an association between ankylosing spondylitis and ulcerative colitis (Steinberg and Storey, 1957;Wilkinson and Bywaters, 1958;Fernandez-Herlihy, 1959;Zvaifler and Martel, 1960;Acheson, 1960;McBride, King, Baikie, Crean, and Sircus, 1963;Wright and Watkinson, 1965;Jayson, Salmon, and Harrison, 1970). The prevalence of these diseases in combination appears to be at least ten and perhaps fifty times greater than would be expected if the association was by chance, on the basis of estimates of prevalence in normal populations (Kellgren, 1964;Evans and Acheson, 1965;Ansell and Lawrence, 1966).…”

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confidence: 99%