Inflammatory Bowel Disease: The Association of Inflammatory Cytokine Gene Polymorphisms

Al-Robayan, Abdulrahman A.; Arfin, Misbahul; Meghaiseeb, Ebtissam Saleh Al; Al-Amro, Reem; Alasmari, Abdulrahman

doi:10.5772/65380

Cited by 2 publications

(1 citation statement)

References 143 publications

(189 reference statements)

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“…Genetic polymorphism in cytokine genes was associated with the risk of development of certain types of cancer. Proinflammatory cytokines promote tumor development, and there is scientific evidence suggesting chronic inflammation can lead to the initiation and progression of cancer in a genetic controlled fashion [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Associations between polymorphisms in the IL-4 gene and renal cell carcinoma in Chinese Han population

Rong

Wang

et al. 2017

Oncotarget

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Renal cell carcinoma (RCC) is considered to be a kind of cytokine reactive tumor. The research has been suggested that the host immune system can regulate the clinical course of RCC. Therefore, cytokine gene polymorphisms in RCC patients were analyzed was necessary. Our study is purpose to analyzing the interleukin-4(IL-4) polymorphisms associated with RCC risk from Han Chinese population. IL-4 genetic polymorphisms were genotyped using Massarray technology from a total of 291RCC and 463 controls. Unconditional logistic regression analysis was performed to analyze their relationship with risk of RCC. A significant association was found between the rs2243250 "C" allel and decreased risk of RCC (OR=0.75, 95%CI=0.59-0.96, P=0.02). Stratified analysis based on the age, gender, smoking status, drinking status revealed no significant association with RCC in age>55, female, smoking and nodrinking. However, for age<55 group (rs2243250, rs2243267, rs2243270), male group (rs2243250), nonsmoking group (rs2227284), and drinking group (rs2243250, rs2227284, rs2243267, rs2243270) polymorphisms were found obviously associated with RCC. The haplotype analyses showed that the haplotype have a significant decreased risk of RCC in the rs2243250/rs2227284/rs2243267/ rs2243270/rs2243283/rs2243289 (CGGACA) (Total, OR=0.73, 95%CI=0.54-0.98, P=0.034; Male, OR=0.59, 95%CI=0.39-0.90, P=0.014). Therefore, the present study suggests that IL-4 may be a candidate gene for assessing the risk of RCC.

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Section: Discussionmentioning

confidence: 99%

Associations between polymorphisms in the IL-4 gene and renal cell carcinoma in Chinese Han population

Rong

Wang

et al. 2017

Oncotarget

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Association of Interleukin-10 Gene Polymorphisms with Ulcerative Colitis

Zhilin

Чашкова

Zhilina

et al. 2021

Acta biomedica scientifica

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Представленный обзор литературы посвящён изучению роли полиморфных вариантов гена противовоспалительного интерлейкина-10 (Interleukin-10, IL-10) в этиологии и патогенезе язвенного колита у пациентов различных этнических групп. Цель. Обобщить результаты, полученные из электронных баз данных, по изучению особенностей течения язвенного колита у пациентов разных этнических групп с учётом носительства полиморфизмов гена IL10. Материалы и методы. Выбрано 25 исследований, в том числе 4 метаанализа, посвящённых изучению ассоциативных связей однонуклеотидных полиморфизмов (single nucleotide polymorphism, SNP) гена IL10, выделенного из образцов крови, в позициях -592АА/СА, -819СТ, -1082АА/GA и rs3024505 в развитии и течении язвенного колита. Результаты. Ряд исследователей из Европы, Саудовской Аравии сообщают о повышенной частоте встречаемости язвенного колита среди носителей SNP IL10-1082AА и низкой у носителей -592АА. Положительные ассоциации IL10-819CT с распространённостью язвенного колита представлены в единичных сообщениях из Европы, Ближнего Востока и в ряде исследований из Азиатских стран. Однако выявленные ассоциации даже в пределах одной популяции нередко носят противоречивый характер. Возможно, разночтения обусловлены этнической гетерогенностью групп в рассматриваемых когортах, в связи с чем необходимо продолжать эпидемиологические исследования с большим объёмом выборки в конкретных географических зонах.

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Inflammatory Bowel Disease: The Association of Inflammatory Cytokine Gene Polymorphisms

Abstract: The frequencies of alleles and genotypes of TNF-α, TNF-β, and IL-10 genes were examined in Saudi subjects including IBD patients (UC and CD) and matched controls.

Cited by 2 publications

References 143 publications

Associations between polymorphisms in the IL-4 gene and renal cell carcinoma in Chinese Han population

Associations between polymorphisms in the IL-4 gene and renal cell carcinoma in Chinese Han population

Association of Interleukin-10 Gene Polymorphisms with Ulcerative Colitis

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