Inflammatory bowel disease therapeutic strategies by modulation of the microbiota: how and when to introduce pre-, pro-, syn-, or postbiotics?

Lê, Amélie; Mantel, Marine; Marchix, Justine; Bodinier, Marie; Jan, Gwenaël; Rolli–Derkinderen, Malvyne

doi:10.1152/ajpgi.00002.2022

Cited by 17 publications

(9 citation statements)

References 289 publications

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“…The etiology of IBD is multi-determinant and involves a complex interaction of genetic predisposition, immune response, and environmental influences. [5] However, the exact cause of this disease is unknown. [1] 1.…”

Section: Figure 1 Etiology Of Ibdmentioning

confidence: 99%

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Impact of probiotics on inflammatory bowel disease - a systematic review

Fijałkowska,

Pełka,

Kania

et al. 2024

J Educ Health Sport

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Introduction: Inflammatory bowel disease (IBD) is a chronic nonspecific inflammatory disease of the gastrointestinal tract that includes ulcerative colitis (UC) and Crohn's disease (CD). Both disease entities have many features in common, such as a basis of chronic inflammation, similar clinical symptoms as well as periods of remission and relapse. The difference between them lies in the lesions location. Treatment of IBD is primarily based on reducing inflammation and maintaining as long a remission time as possible. Increasing evidence is being attributed to the therapeutic potential of probiotics in IBD. Purpose: This review aims to present the preventive and therapeutic effects of probiotic use in IBS through an analysis of recent studies. Methods: A review of recent literature was conducted to investigate the impact of probiotic use on the treatment of IBD. Results: In studies, probiotics help induce and maintain remission in patients with mild to moderate ulcerative colitis, especially when used in combination therapy. In contrast, the usage of probiotics in Crohn's disease does not provide due benefit: it does not induce or prolong remission. Conclusions: In conclusion, the effect of probiotics on IBD is inconclusive. Some probiotics, particularly the VSL#3 probiotic blend, have shown decent effects on induction and remission in patients with mild to moderate UC. However, no therapeutic effect has been demonstrated in patients with Crohn's Disease. Therefore studies under more restrictive and standardized conditions are required.

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Section: Figure 1 Etiology Of Ibdmentioning

confidence: 99%

“…Over 240 genetic risk loci are associated with IBD, with a significant portion (30%) of these loci being common to both Crohn's disease and ulcerative colitis. [5] However, these genetic factors alone are not sufficient to cause the disease and must interact with other stimuli to lead to the IBD.…”

Section: Figure 1 Etiology Of Ibdmentioning

confidence: 99%

Impact of probiotics on inflammatory bowel disease - a systematic review

Fijałkowska,

Pełka,

Kania

et al. 2024

J Educ Health Sport

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“…An association of dysbiosis in IBD pathogenesis is also evident. Consequently, the administration of probiotics and their derivatives might be considered for reducing the inflammation or even strengthening the intestinal epithelial barrier [ 95 ]. Postbiotics mainly refer to biologically active components secreted by bacteria [ 96 ].…”

Section: A Potential Innovative Strategy By Postbiotic Treatmentmentioning

confidence: 99%

Inflammatory Bowel Diseases and Gut Microbiota

Haneishi

Furuya

Hasegawa

et al. 2023

IJMS

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Inflammatory bowel disease (IBD) is an inflammatory disease of the gastrointestinal tract, the incidence of which has rapidly increased worldwide, especially in developing and Western countries. Recent research has suggested that genetic factors, the environment, microbiota, and immune responses are involved in the pathogenesis; however, the underlying causes of IBD are unclear. Recently, gut microbiota dysbiosis, especially a decrease in the abundance and diversity of specific genera, has been suggested as a trigger for IBD-initiating events. Improving the gut microbiota and identifying the specific bacterial species in IBD are essential for understanding the pathogenesis and treatment of IBD and autoimmune diseases. Here, we review the different aspects of the role played by gut microbiota in the pathogenesis of IBD and provide a theoretical basis for modulating gut microbiota through probiotics, fecal microbiota transplantation, and microbial metabolites.

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“…Given the recognized role of gut microbiota in preserving intestinal homeostasis, treatments aiming to induce or sustain remission in IBD patients by restoring a healthy microbial environment have been proposed and are still ongoing, showing promising success [161]. Manipulating the gut microbiota may be the best choice proposed as a weapon in the challenge of IBD.…”

Section: Therapeutic Strategies For Manipulating Intestinal Microbiotamentioning

confidence: 99%

The Dynamic Crosstalk between Gut Microbiota, Immune System, and Autophagy in the Onset of Inflammatory Bowel Disease: Molecular Mechanisms and Current Therapeutic Approaches

Garavaglia,

Vallino,

Amoruso

et al. 2023

Preprint

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The crosstalk between gut microbiota, intestinal epithelial cells, and innate and adaptive immune system governs the maintenance of the intestinal homeostasis. Any interference in this tight dialogue and in the processes preserving cellular homeostasis (e.g., autophagy) may dysregulate the immune response and impair the clearance of harmful bacteria favoring the dysbiotic alteration of the microbic flora that leads to chronic inflammation. Gut dysbiosis is strongly associated with gastrointestinal inflammatory disorders, among them the inflammatory bowel disease (IBD). This review discusses the current knowledge on IBD, from the genetic background of high-risk patients to the molecular mechanisms underlying the disease, the contribution of the microbic flora, and the role of autophagy in intestinal epithelial cells and provides the state of art regarding the targeted-nutritional approaches aimed to restore the beneficial crosstalk between an “anti-inflammatory” microbiota and the host. Analysis of the molecular pathogenesis of IBD will help identify genetic and diet-associated risk factors and thus suggest personalized strategies to prevent and manage the disease to improve quality of life with long-term maintenance of the remission phase.

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Inflammatory bowel disease therapeutic strategies by modulation of the microbiota: how and when to introduce pre-, pro-, syn-, or postbiotics?

Cited by 17 publications

References 289 publications

Impact of probiotics on inflammatory bowel disease - a systematic review

Impact of probiotics on inflammatory bowel disease - a systematic review

Inflammatory Bowel Diseases and Gut Microbiota

The Dynamic Crosstalk between Gut Microbiota, Immune System, and Autophagy in the Onset of Inflammatory Bowel Disease: Molecular Mechanisms and Current Therapeutic Approaches

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