Inflammatory Bowel Diseases Accompanied by Renal Impairment

Àlex,; Skamnelos, ros; Giagkou, Eftychia; Malakos, Zikos; Κατσάνος, Κωνσταντίνος; Christodoulou, Dimitrios

doi:10.21767/2472-5056.100001

Cited by 3 publications

(4 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another potential mechanism for the development of ESRD in patients with CD might be related to autoimmune susceptibility, which is involved in the pathogenesis of CD. Finally, ESRD might be induced by the secondary complications of chronic intestinal inflammation, such as metabolic or nutritional disorders[12,13]. Especially in CD, nutritional problems, such as dehydration and electrolyte depletion, are more prominent due to persistent inflammation of the intestine and repeated intestinal resection, leading to electrolyte abnormalities and recurrent acute renal failure, resulting in CKD[30].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Increased end-stage renal disease risk in patients with inflammatory bowel disease: A nationwide population-based study

Park

Chun

Han

et al. 2018

WJG

View full text Add to dashboard Cite

AIMTo estimate the risk of end-stage renal disease (ESRD) in patients with inflammatory bowel disease (IBD).METHODSFrom January 2010 to December 2013, patients with Crohn’s disease (CD) and ulcerative colitis (UC) were identified, based on both the International Classification of Diseases, 10th revision (ICD-10) and the rare, intractable disease registration program codes from the National Health Insurance (NHI) database in South Korea. We compared 38812 patients with IBD to age- and sex-matched non-IBD controls with a ratio of 1:3. Patients newly diagnosed with ESRD were identified with the ICD-10 code.RESULTSDuring a mean follow-up of 4.9 years, ESRD was detected in 79 (0.2%) patients with IBD and 166 (0.1%) controls. The incidence of ESRD in patients with IBD was 0.42 per 1000 person-years. Patients with IBD had a significantly higher risk of ESRD than controls [adjusted hazard ratio (HR) = 3.03; 95% confidence interval (CI): 1.77-5.20; P < 0.001]. The incidences (per 1000 person-years) of ESRD were 0.51 in patients with CD and 0.13 in controls, respectively (adjusted HR = 6.33; 95%CI: 2.75-14.56; P < 0.001). In contrast, the incidence of ESRD was similar between the UC and control groups (0.37 vs 0.37 per 1000 person-years; adjusted HR = 2.01; 95%CI: 0.90-4.51; P = 0.089).CONCLUSIONThe risk of ESRD was elevated in patients with CD, but not UC. Patients with CD should be monitored carefully for signs of renal insufficiency.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Each of these conditions can induce renal insufficiency. Kidney injury may also result from dehydration, malnutrition, or medication side effects in patients with IBD[12,13]. A few epidemiologic studies have reported incidences of renal insufficiency that ranged from 2.0% to 15.9% in patients with IBD[14,15].…”

Section: Introductionmentioning

confidence: 99%

Increased end-stage renal disease risk in patients with inflammatory bowel disease: A nationwide population-based study

Park

Chun

Han

et al. 2018

WJG

View full text Add to dashboard Cite

show abstract

“…The involvement of the immune system in the pathogenesis of CD suggests another possible explanation for the onset of ESRD in CD patients. Finally, metabolic or nutritional abnormalities that arise as a result of persistent intestinal inflammation may contribute to end-stage renal disease [18,19] . Chronic intestinal inflammation and intestinal resection increase the risk of electrolyte imbalances and recurrent acute renal failure, both of which may lead to chronic kidney disease (CKD), making nutritional issues like dehydration and electrolyte depletion more prevalent in CD [20] .…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of renal insufficiency in inflammatory bowel disease patients in Tanta University Hospitals

Elaaty,

Abbas,

Gawaly

et al. 2023

Int. J. Adv. Res. Med.

View full text Add to dashboard Cite

Background: Inflammatory bowel diseases (IBD) are chronic immune mediated intestinal conditions. The objective of this research is to investigate the epidemiology of renal insufficiency among patients with IBD who were hospitalized in Tanta University Hospitals. Methods: A cross-sectional research was conducted on 100 patients who exhibited clinical criteria indicative of Crohn's disease (CD) or Ulcerative colitis (UC). Glomerular filtration rate (GFR) and blood creatinine were evaluated. Patients were categorized into two groups: CD group (N=8), and UC group (N=92). The diagnosis of renal insufficiency in these patients was conducted by measuring GFR and blood creatinine levels using the modification of diet and renal disease (MDRD) study equation. Results: IBD-related surgeries were significantly higher in CD (50% Vs 10.87% in UC). Renal impairment in IBD patients was higher with increasing age, the co-existence of Hyperlipidaemia, Diabetes mellitus and with the use of antibiotic, NSAIDs, acetaminophen, and azathioprine, also with IBD related surgeries and extra intestinal manifestations (EIMs) as Arthritis and Uveitis. Regarding univariate analysis, Age, HTN and Acetaminophen use were significant risk factors for IBD (OR= 1.227; p= 0.004, 14.333; p=0.006 and 6.882; p= 0.043) respectively. Regarding multivariate analysis, only age was a significant risk factor for IBD (OR= 1.254; p= 0.027). Conclusions: Renal impairment was found in 16% of the cases, we reported that renal impairment was significantly higher with increasing age, the co-existence of DM, hyperlipidaemia and with the use of azathioprine, Nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen and antibiotic. Also, with IBD related surgeries and EIMs as arthritis and uveitis.

show abstract

“…Renal involvement has been linked to a variety of pathological processes. Kidney damage can be caused by the disease itself, as well as consequent extra intestinal problems (malnutrition) and therapeutic side effects [21]. Increased blood urea nitrogen indicates pre-renal uremia, which is caused by a reduced glomerular filtration rate and tissue catabolism as a result of fever [22].…”

Section: Discussionmentioning

confidence: 99%

Ultrasound, Hematological and Biochemical Analysis in Canine with Inflammatory Bowel Disease

El-Zahar

El-Rahman

El-Naggar

2021

Zagazig Veterinary Journal

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD) in dogs is a group of disorders characterized by persistent gastrointestinal clinical manifestations. The goal of this study was to investigate the hematobiochemical alterations in association with the clinical outcomes and prognostic markers including cobalamine, folate and vitamin D3 in dogs with IBD. A total of 23 IBD dogs with symptoms of chronic gastrointestinal diseases were chosen for the study, these include vomiting, diarrhea, anorexia, weight loss and abdominal pain. Ultrasonographically, the most common IBD-related abnormalities were dilated intestinal loops with hypermotility, as well as thickening and loss of wall layers in the stomach, duodenum, and jejunum. Hematological findings showed significant increase in the total white blood cell count (14.58 ± 0.49) and neutrophils (69.8 ± 1.6), and significant decrease in hemoglobin (9.83 ± 0.44) and Hematocrit value (30.30 ± 1.24). Biochemical analysis revealed significant increase in serum activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen and blood creatinine compared to the controls. Whilst significant decrease in serum 25(OH)D, folate and cobalamin levels in IBD dogs was observed which indicate intestinal malabsorption, and these markers are good predictors of IBD.

show abstract

Inflammatory Bowel Diseases Accompanied by Renal Impairment

Cited by 3 publications

References 13 publications

Increased end-stage renal disease risk in patients with inflammatory bowel disease: A nationwide population-based study

Increased end-stage renal disease risk in patients with inflammatory bowel disease: A nationwide population-based study

Epidemiology of renal insufficiency in inflammatory bowel disease patients in Tanta University Hospitals

Ultrasound, Hematological and Biochemical Analysis in Canine with Inflammatory Bowel Disease

Contact Info

Product

Resources

About