Inflammatory cells implicated in neoplasia development in idiopathic inflammatory bowel disease

Hashash, Jana G.; Hartman, Douglas J.

doi:10.1016/j.cellimm.2017.11.004

Cited by 3 publications

(3 citation statements)

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“…Epidemiological data indicate that approximately 1.5 million people in North America are affected by IBD[ 2 ], and that 25% of individuals with IBD develop the condition before the age of 25[ 3 ]. The pathogenesis of IBD is not fully understood; however, it is generally believed to be linked to environmental factors acting on genetically predisposed individuals, triggering an uncontrolled inflammatory response mediated by the immune system[ 4 ]. The chronic inflammatory re-sponse in patients with IBD heightens the risk of cardiovascular diseases, including heart failure and atrial fibrillation, and often necessitates surgeries and frequent hospitalizations[ 5 , 6 ] that can significantly affect the quality of life in patients[ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Irregular diet, physical inactivity, and smoking are considered major risk factors for IBD[ 12 - 14 ]. Controlling these risk factors can help to reduce the risk of IBD[ 4 , 15 ]. As research has progressed, researchers have recognized the potential link between type 1 diabetes (T1D) and IBD, suggesting a possible involvement of T1D in IBD induction[ 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Does type 1 diabetes serve as a protective factor against inflammatory bowel disease: A Mendelian randomization study

Tong,

Yu,

Yang

et al. 2024

World J Diabetes

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BACKGROUND The impact of type 1 diabetes (T1D) on inflammatory bowel disease (IBD) remains unclear. AIM To analyze the causal relationship between T1D and IBD using Mendelian ran-domization (MR). METHODS Single nucleotide polymorphisms were sourced from FinnGen for T1D, IBD, ulcerative colitis (UC) and Crohn’s disease (CD). Inverse variance-weighted, MR-Egger, and weighted median tests were used to assess exposure-outcome causality. The MR-Egger intercept was used to assess horizontal pleiotropy. Co-chran’s Q and leave-one-out method were used to analyze heterogeneity and sensitivity, respectively. RESULTS Our MR analysis indicated that T1D was associated with a reduced risk of IBD [odds ratio (OR): 0.959; 95% confidence interval (CI): 0.938-0.980; P < 0.001] and UC (OR: 0.960; 95%CI: 0.929-0.992; P = 0.015), with no significant association observed in terms of CD risk (OR: 0.966; 95%CI: 0.913-1.022; P = 0.227). The MR-Egger intercept showed no horizontal pleiotropy (P > 0.05). Cochran’s Q and leave-one-out sensitivity analyses showed that the results were not heterogeneous (P > 0.05) and were robust. CONCLUSION This MR analysis suggests that T1D serves as a potential protective factor against IBD and UC but is independent of CD.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Does type 1 diabetes serve as a protective factor against inflammatory bowel disease: A Mendelian randomization study

Tong,

Yu,

Yang

et al. 2024

World J Diabetes

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“…The intestinal immune system is well controlled and balanced at all levels in healthy individuals. Inflammatory bowel disease causes epithelial neutrophilic inflammation followed by loss of epithelial integrity, chronic inflammation (usually characterized by secretion of lymphocytes and phagocytes), and epithelial metaplasia 6 . However, current studies on immune disorders in IBD mainly focus on the profile and function of lymphocytes, but the role of neutrophils in IBD has not been elucidated.…”

Section: Introductionmentioning

confidence: 99%

DNase aggravates intestinal microvascular injury in IBD patients by releasing NET‐related proteins

Shao,

Li,

Yang

et al. 2023

The FASEB Journal

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Neutrophils accumulate in the inflammatory mucosa of patients with inflammatory bowel disease (IBD), and excessive release of NETs (neutrophil extracellular traps may be one of the important factors that cause IBD progression. However, the specific mechanism underlying vascular injury caused by NETs remains unclear. Immunofluorescence, ELISA, and flow cytometry were used in this study to detect the expression of NETs and DNase in the tissue and peripheral blood samples of patients with IBD. DSS mouse model was used to detect colon injury and vascular permeability. We found that NETs and DNase levels increased in the colon of patients with IBD. We found an increase in the activity of NET‐related MPO released by DNase. DNase released NET‐related proteins and damaged vascular endothelial cells in vitro. In DSS mouse model, the synchronous increase of DNase and NETs in the colon leads to an increase in vascular injury markers (CD44, sTM). DNase aggravated colon injury and increased vascular permeability in vivo, which was inhibited by gentamicin sulfate (GS). GS does not reduce the expression of DNase, but rather reduces the release of NET‐related proteins to protect vascular endothelium by inhibiting DNase activity. MPO and histones synergistically damaged the vascular endothelium, and vascular injury can be improved by their active inhibitors. We further found that H2O2 is an important substrate for MPO induced vascular damage. In conclusion, in IBD, DNase, and NET levels increased synchronously in the lesion area and released NET‐related proteins to damage the vascular endothelium. Therefore, targeting DNase may be beneficial for the treatment of IBD.

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Establish and apply ISI pathological method to evaluate the intestinal health of largemouth bass (Micropterus salmoides) and channel catfish (Ictalurus punctatus) challenged with Aeromonas hydrophila

Huang

Wei

et al. 2023

Israeli Journal of Aquaculture - Bamidgeh

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Gut health is essential for animal growth because it can absorb nutrients more efficiently, promote growth, and protect the body from invasion by pathogenic microorganisms. Temperature, dissolved oxygen, water quality, nutrition level, pathogen, net fishing, and so on will affect the gut health of aquatic animals. Intestinal diseases in aquatic animals were often not easily detected, making them difficult to prevent and control. Therefore, establishing a stable and scientific evaluation standard of gut health was of great significance. This study evaluated the effects of gross pathological and histological parameters of largemouth bass and channel catfish infected by Aeromonas hydrophila. A total of 150 largemouth bass and 150 channel catfish were randomly divided into 5 groups: 1 control group (NC) and 4 challenge groups (CH, fish were infected with A. hydrophila by intraperitoneal injection with a concentration of 200 µL 1x108 CFU/mL, 1x107 CFU/mL, 1x106 CFU/mL, and 1x105 CFU/mL, respectively). After the challenge, largemouth bass’ gross pathological and histological changes were observed on the 2nd, 6th, 9th, 12th, and 14th days. In contrast, channel catfish’s gross pathological and histological changes were observed on the 3rd, 6th, 9th, 12th, and 15th day. In this study, regarding the “I See Inside” (ISI) methodology of poultry, a pathological evaluation method of fish intestinal health was established to comprehensively evaluate the intestinal health status of fish by gross pathological and histopathological score. In gross pathology, it was scored by the body surface and intestinal lesions. In histology, it was a metric evaluation of histological alterations in the intestine, converting macroscopic and microscopic alterations into numbers and then scoring. Each evaluation parameter sets up an “influence factor” (IF) according to the degree of influence of its pathological changes on intestinal function. The final score was the sum of the IF product and this parameter’s score. The results of two kinds of fish showed that the gross pathological and histopathological scores correlated with the infection dose and time. And the significant difference in the score between the enteritis and control groups was observed. The results showed that the higher score, the more serious the pathological changes of fish infected by A. hydrophlia. From this, it can be concluded that the pathological evaluation method established can be used to evaluate the gut health of fish.

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Inflammatory cells implicated in neoplasia development in idiopathic inflammatory bowel disease

Cited by 3 publications

References 54 publications

Does type 1 diabetes serve as a protective factor against inflammatory bowel disease: A Mendelian randomization study

Does type 1 diabetes serve as a protective factor against inflammatory bowel disease: A Mendelian randomization study

DNase aggravates intestinal microvascular injury in IBD patients by releasing NET‐related proteins

Establish and apply ISI pathological method to evaluate the intestinal health of largemouth bass (Micropterus salmoides) and channel catfish (Ictalurus punctatus) challenged with Aeromonas hydrophila

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