Inflammatory cytokines in animal health and disease

Murtaugh, Michael P.; Baarsch, Mary Jo; Zhou, Yingshan; Scamurra, Ronald W.; Lin, Gaofeng

doi:10.1016/s0165-2427(96)05698-x

Cited by 122 publications

(73 citation statements)

References 47 publications

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“…The fact that iNOS was found in all tissues from the pigs without a difference between the CPB-and shamgroup at any time could indicate a constitutive expression without any up-regulation in response to external stimuli (15). Moreover, there was also an equal decrease in expiratory NO in the two groups that terminated 0.5 h post-CPB.…”

Section: Discussionmentioning

confidence: 88%

Plasma cytokines do not reflect expression of pro‐ and anti‐inflammatory cytokine mRNA at organ level after cardiopulmonary bypass in neonatal pigs*

Christensen

Vestergaard²,

Chew

et al. 2003

Acta Anaesthesiol Scand

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Section: Discussionmentioning

confidence: 88%

Plasma cytokines do not reflect expression of pro‐ and anti‐inflammatory cytokine mRNA at organ level after cardiopulmonary bypass in neonatal pigs*

Christensen

Vestergaard²,

Chew

et al. 2003

Acta Anaesthesiol Scand

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“…This contributes to the mobilization of host defences and recruitment of other immune cells required for control of an infection, but may also exacerbate some aspects of disease (reviewed by Murtaugh et al, 1996). The release of three proinflammatory cytokines by macrophages infected with different serotypes was quantified to determine whether this correlates with the different disease syndromes.…”

Section: Discussionmentioning

confidence: 99%

Interaction of Salmonella serotypes with porcine macrophages in vitro does not correlate with virulence

et al. 2000

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The interaction between Salmonella serotypes and macrophages is potentially instrumental in determining the outcome of infection. The nature of this interaction was characterized with respect to virulence and serotype-host specificity using pigs as the infection model. Experimental infection with Salmonella typhimurium , Salmonella choleraesuis or Salmonella dublin resulted in enteric, systemic or asymptomatic infection, respectively, which correlates well with the association of S. choleraesuis with systemic disease in pigs in epidemiological studies. Persistence within porcine alveolar macrophages in vitro did not directly correlate with virulence since S. typhimurium persisted in the highest numbers, and S. choleraesuis in the lowest. Comparison to other studies revealed that the relatively high persistence of S. typhimurium in macrophages correlates with its virulence in a broad range of animals : this could be a virulence mechanism for broad-hostrange serotypes. There were little or no significant differences in the induction of pro-inflammatory cytokines by macrophages infected with the three serotypes. S. typhimurium and S. dublin, but not S. choleraesuis, damaged porcine macrophages, and the mechanism of damage did not resemble apoptosis. In conclusion, the virulence of Salmonella serotypes in pigs did not directly correlate with their interaction with porcine macrophages in vitro. The interaction of Salmonella and macrophages in vitro may not accurately model their interaction in vivo, and this will form the basis of further study.

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“…Hierzu gehören folgende proinflammatorische Zytokine: Interleukin-1 (IL-1), IL-6 und der Tumornekrosefaktor-α (TNF-α) (Murtaugh et al, 1996). Diese Zytokine sind bekannt als Auslöser der Akuten-Phase-Reaktion, der Entzündungsreaktionen, der Aktivierung von Endothelzellen und der Apoptose.…”

Section: Die Anschließende Virusreplikation Erfolgt Primär In Den Zelunclassified

3.3 Afrikanische Schweinepest

Mayr¹

2007

Medizinische Mikrobiologie, Infektions- Und Seuchenlehre

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Inflammatory cytokines in animal health and disease

Cited by 122 publications

References 47 publications

Plasma cytokines do not reflect expression of pro‐ and anti‐inflammatory cytokine mRNA at organ level after cardiopulmonary bypass in neonatal pigs*

Plasma cytokines do not reflect expression of pro‐ and anti‐inflammatory cytokine mRNA at organ level after cardiopulmonary bypass in neonatal pigs*

Interaction of Salmonella serotypes with porcine macrophages in vitro does not correlate with virulence

3.3 Afrikanische Schweinepest

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