Inflammatory macrophages facilitate mechanical stress-induced osteogenesis

Zhang, Fan; Huan, Le; Xu, Tao; Li, Guozheng; Zheng, Bing; Zhao, Hong; Guo, Yongfei; Shi, Jiangang; Chen, Aimin

doi:10.18632/aging.102833

Cited by 13 publications

(5 citation statements)

References 22 publications

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“…However, sparse data are available examining structural changes in the hip bones in individuals with hip OA. Inflammatory insults contribute to the heterogenic pattern of OA pathogenesis, guiding destruction and regeneration of injured bone and cartilage 17 . Non-steroidal anti-inflammatory drugs and physiotherapy are the mainstay of treatment, while to date, no regenerative therapy has been established in clinical practice and patients mainly undergo hip replacement.…”

Section: Introductionmentioning

confidence: 99%

Immune and stem cell compartments of acetabular and femoral bone marrow in hip osteoarthritis patients

Trivanović

Harder²,

Leucht³

et al. 2022

Osteoarthritis and Cartilage

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Section: Introductionmentioning

confidence: 99%

Immune and stem cell compartments of acetabular and femoral bone marrow in hip osteoarthritis patients

Trivanović

Harder²,

Leucht³

et al. 2022

Osteoarthritis and Cartilage

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“…These signals derived from a mixture of burst platelets, which release its cytokines and growth factors (a) from factors of the activated coagulation system (b) as well as from the activated complement (c) and immune system (d) [45]. Some signals may also be released by the ripped tissue fragments (e) such as soft tissue (fat, muscle, fascia, and periosteum), as well as bone and its marrow [46][47][48][49][50][51][52]. These effects are accompanied by local electrolyte displacement such as increased extracellular K + due to cellular death and result in at least an aseptic inflammation as shown in Figure 1.…”

Section: Discussionmentioning

confidence: 99%

Surgical Site-Released Tissue Is Potent to Generate Bone onto TCP and PCL-TCP Scaffolds In Vitro

Rehage,

Sowislok,

Busch

et al. 2023

IJMS

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There is evidence that surgical site tissue (SSRT) released during orthopedic surgery has a strong mesenchymal regenerative potential. Some data also suggest that this tissue may activate synthetic or natural bone substitute materials and can thus upgrade its osteopromoting properties. In this comparative in vitro study, we investigate the composition of SSRT during total hip replacement (n = 20) harvested using a surgical suction handle. In addition, the osteopromoting effect of the cells isolated from SSRT is elucidated when incubated with porous beta-tricalcium phosphate (β-TCP) or 80% medical-grade poly-ε-caprolactone (PCL)/20% TCP composite material. We identified multiple growth factors and cytokines with significantly higher levels of PDGF and VEGF in SSRT compared to peripheral blood. The overall number of MSC was 0.09 ± 0.12‰ per gram of SSRT. A three-lineage specific differentiation was possible in all cases. PCL-TCP cultures showed a higher cell density and cell viability compared to TCP after 6 weeks in vitro. Moreover, PCL-TCP cultures showed a higher osteocalcin expression but no significant differences in osteopontin and collagen I synthesis. We could demonstrate the high regenerative potential from SSRT harvested under vacuum in a PMMA filter device. The in vitro data suggest advantages in cytocompatibility for the PCL-TCP composite compared to TCP alone.

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“…9,38,50 The stretching of the disc annulus fibrosus can activate the Cox-2 pathways, resulting in increased production of prostaglandin E2 (PGE2), which can cause hyperalgesia and mechanical allodynia, contributing to pain. 51,52 Spaceflight also impacts bone health by stimulating bone resorption. 53 Bone turnover, which is generally a slow process, increases significantly within 10 to 14 days of spaceflight and remains stable thereafter.…”

Section: Potential Explanations Of Findingsmentioning

confidence: 99%

Pain Experience and Sensory Changes in Astronauts During and After Short-Lasting Commercial Spaceflight: A Proof-of-Concept Study

Sauer,

Vigouroux,

Dougherty

et al. 2023

JPR

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Space travel has been associated with musculoskeletal pain, yet little is known about the nociceptive changes and pain experience during spaceflight. This preliminary study aims to investigate the pain experience and sensory alterations in astronauts following a 17-day mission to the International Space Station (ISS) on Axiom Space's AX-1 commercial space flight. Two participants were enrolled, and data were collected pre-flight, in-flight, post-flight, and three-month post-flight. Validated pain questionnaires assessed anxiety, catastrophizing, impact on physical and mental health, disability, and overall pain experience. Qualitative interviews were conducted post-landing and conditioned pain modulation (CPM) and quantitative sensory testing (QST) were performed. Both astronauts reported musculoskeletal pain during and after the flight, which was managed with anti-inflammatories and stretching techniques. Pain levels returned to baseline after three months. Pain questionnaires revealed heightened pain experiences in-flight and immediately post-flight, although their adequacy in assessing pain in space is uncertain. Qualitative interviews allowed astronauts to describe their pain experiences during the flight. Sensory changes included increased mechanical touch detection thresholds, temporal pain summation, heat pain thresholds, and differences in conditioned pain modulation post-flight. This preliminary study suggested that spaceflight may affect various aspects of sensory perception and regulation in astronauts, albeit in a variable manner. More data are needed to gain insight of on gain and loss of sensory functions during space missions. Further investigation into the multifactorial stressors affecting the somatosensory system during space travel could contribute to advancements in space and pain medicine.

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Inflammatory macrophages facilitate mechanical stress-induced osteogenesis

Cited by 13 publications

References 22 publications

Immune and stem cell compartments of acetabular and femoral bone marrow in hip osteoarthritis patients

Immune and stem cell compartments of acetabular and femoral bone marrow in hip osteoarthritis patients

Surgical Site-Released Tissue Is Potent to Generate Bone onto TCP and PCL-TCP Scaffolds In Vitro

Pain Experience and Sensory Changes in Astronauts During and After Short-Lasting Commercial Spaceflight: A Proof-of-Concept Study

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