Inflammatory marker levels after hybrid treatment of selected congenital heart disease in children

Haponiuk, Ireneusz; Chojnicki, Maciej; Jaworski, Radosław; Steffens, Mariusz; Szofer-Sendrowska, Aneta; Paczkowski, Konrad; Juściński, Jacek; Kwaśniak, Ewelina; Szymanowicz, Wiktor; Gierat-Haponiuk, Katarzyna; Leszczyńska, Katarzyna; Romanowicz, Anna; Zieliński, Jacek

doi:10.5603/kp.a2014.0091

Cited by 3 publications

(1 citation statement)

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“…The latter finding was also confirmed by the present observations. The other basic platelet indices such as MPV and PDW were found to be elevated after procedures associated with iatrogenic injury [ 25 , 26 ]. Higher values of MPV and PDW after surgical procedures may be a net result of two biological processes both driven by tissue damage.…”

Section: Discussionmentioning

confidence: 99%

Mean platelet volume-to-platelet count ratio after elective cardiac surgical procedures is superior in reflecting platelets metabolic hyperactivity compared to other routine morphological platelet indices: A preliminary report

et al. 2021

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Background Excessive metabolic excitation of platelets after cardiac procedures may be related to some adverse events but assessment of their metabolic activity is not routine. The purpose of this study was to evaluate which of the basic platelet morphological parameters best reflects their metabolic status. Methods The blood samples of 22 cardiac surgical patients (mean age of 62.3 ± 10.3 years) were taken before surgery (BS), and 1, 24 and 48 hours after the operation. Correlations between morphological platelet parameters (platelet count [PLT], mean platelet volume [MPV], platelet distribution width [PDW] and MPV/PLT) and their metabolic activity (total concentration of malondialdehyde [MDA] and MDA/PLT) were estimated. Results Significant decline in PLT after operation (from 223 ± 44 × 10 12 /L to 166 ± 57 × 10 12 /L) was accompanied by marked increase in MPV (from 8.4 ± 0.9 fL to 9.1 ± 1.2 fL) and no change of PDW. Consequently, MPV/PLT index increased significantly after procedures from (median with IQR) 0.038 (0.030–0.043) to 0.053 (0.043–0.078). Simultaneously, a significant increase in total platelet MDA content and MDA/PLT was noted reaching peak levels soon after operation. The strongest correlation was observed between MPV/PLT and MDA/PLT (r = 0.56; p < 0.001), although the others were also found to be significant (MDA/PLT vs. MPV; r = 0.35; MDA/PLT vs. PDW; r = 0.34). Conclusions Among basic morphological parameters and indices, the MPV-to-PLT ratio reflects the best metabolic status of platelets in cardiac surgical patients.

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Section: Discussionmentioning

confidence: 99%