Inflammatory Markers and the Risk of Coronary Heart Disease in Men and Women

Pai, Jennifer K.; Pischon, Tobias; Ma, Jing; Manson, JoAnn E.; Hankinson, Susan E.; Joshipura, Kaumudi; Curhan, Gary C.; Rifai, Nader; Cannuscio, Carolyn C.; Stampfer, Meir J.; Rimm, Eric B.

doi:10.1056/nejmoa040967

Cited by 1,022 publications

(486 citation statements)

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“…In accordance with our findings where sTNFR1 was associated with cardiovascular mortality after adjustments for CRP and IL-6, sTNFR1 but not IL-6 and CRP was associated with left ventricular mass in a study of over 600 patients with stroke [22]. Elevated levels of sTNFR1 and STNFR2 have also been associated with incident coronary heart disease in women with a low kidney function [23,24], and elevated levels of sTNFR2 were associated with incident coronary heart disease independently of hyperglycemia a 10-year follow-up of almost one thousand nurses with diabetes [25].…”

Section: Comparisons With Previous Studiessupporting

confidence: 91%

Soluble tumor necrosis factor receptor 1 (sTNFR1) is associated with increased total mortality due to cancer and cardiovascular causes – Findings from two community based cohorts of elderly

et al. 2014

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Section: Comparisons With Previous Studiessupporting

confidence: 91%

Soluble tumor necrosis factor receptor 1 (sTNFR1) is associated with increased total mortality due to cancer and cardiovascular causes – Findings from two community based cohorts of elderly

et al. 2014

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“…Inflammation is considered to play a substantial role in the pathophysiological process of cardiac remodeling and results in subsequent adverse events after AMI. Innate immune cells of the neutrophils and monocytes/macrophages are present in the development of atherosclerotic lesions,1, 2, 3 and their activation may contribute significantly to plaque instability 4, 5, 6. Acute myocardial ischemia induces a systemic immediate‐phase response of the immune system, leading to cytokine and chemokine production and to the recruitment of neutrophils and mononuclear cells in the infarcted region of the heart 7, 8…”

Section: Introductionmentioning

confidence: 99%

Prognostic Utility of Soluble TREM‐1 in Predicting Mortality and Cardiovascular Events in Patients With Acute Myocardial Infarction

Wang

Tang

Shen

et al. 2018

JAHA

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BackgroundTriggering receptor expressed on myeloid cells‐1 (TREM‐1) is thought to be critical for inflammatory signal amplification and involved in the development of atherosclerosis. TREM‐1 is significantly increased in patients with myocardial infarction. The aim of this study was to investigate the association between soluble TREM‐1 (sTREM‐1) and mortality and cardiovascular events in patients with acute myocardial infarction.Methods and ResultsWe included 838 consecutive patients with acute myocardial infarction from October 7, 2012 to December 5, 2014. Blood samples were collected from patients with acute myocardial infarction immediately after diagnosis. During follow‐up, 88 patients died, and 180 patients reached the combined end points of major adverse cardiovascular event (MACE). Patients with high sTREM‐1 (higher than the median) had increased risk of all‐cause mortality and MACE compared with those with low sTREM‐1 (log‐rank test, P<0.001). After adjustment for confounding risk factors by Cox regression analysis, high sTREM‐1 remained an independent predictor of all‐cause mortality (hazard ratio, 1.978; 95% confidence interval, 1.462–2.675; P<0.001) and MACE (hazard ratio, 2.413; 95% confidence interval, 2.022–2.879; P<0.001). After the addition of sTREM‐1 to the reference model, the C‐statistic for all‐cause mortality increased from 0.86 to 0.89, and the difference was 0.023 (95% confidence interval, 0.0009–0.0477), and the C‐statistic for MACE increased from 0.71 to 0.80, and the difference was 0.087 (95% confidence interval, 0.053–0.122). sTREM‐1 levels were consistently positively associated with risks of all‐cause mortality and MACE in various subpopulations, and there was no significant interaction among prespecified subgroups.Conclusions sTREM‐1 was significantly associated with all‐cause mortality and MACE, independent of established conventional risk factors in patients with acute myocardial infarction.

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“…Chronic inflammation has also been implicated as playing a role in cardiovascular disease (Davison and Davis 2003). To this end, elevations in C-reactive protein (CRP), an inflammation biomarker, may be considered an important independent indicator of mortality for cardiovascular and metabolic diseases (Kengne et al 2012;Pai et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Effect of resistance training on C-reactive protein, blood glucose and lipid profile in older women with differing levels of RT experience

Ribeiro

Tomeleri

Souza

et al. 2015

AGE

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The purpose of this study was to analyze the effects of a progressive resistance training (RT) program on C-reactive protein (CRP), blood glucose (GLU), and lipid profile in older women with differing levels of RT experience. Sixty-five older women (68.9 ± 6.1 years, 67.1 ± 13.1 kg) were separated according to RT experience: an advanced group composed by 35 participants who previously carried out 24 weeks of RT and a novice group composed by 30 participants without previous experience in RT (n = 30). Both groups performed a RT program comprised of eight exercises targeting all the major muscles. Training was carried out 3 days/week for 8 weeks. Serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), GLU, and CRP concentrations were determined pre-and post-intervention after 12 h fasting. A significant group by time interaction (P < 0.05) for the TC (novice = −1.9 % vs. advanced = 1.0 %), and CRP (novice = −22.9 % vs. advanced = −54.5 %) was observed. A main effect of time (P < 0.05) was identified for the GLU (novice = −2.6 % vs. advanced = −6.6 %), TG (novice = −12.9 % vs. advanced = −5.7 %), HDL-C (novice = +6.7 % vs. advanced = +2.6 %), and LDL-C (novice = −34.0 % vs. advanced = −25.4 %). These results suggest that RT improves the metabolic profile of older women and that training for a longer period of time seems to produce more pronounced reductions mainly on CRP.

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Inflammatory Markers and the Risk of Coronary Heart Disease in Men and Women

Cited by 1,022 publications

References 45 publications

Soluble tumor necrosis factor receptor 1 (sTNFR1) is associated with increased total mortality due to cancer and cardiovascular causes – Findings from two community based cohorts of elderly

Soluble tumor necrosis factor receptor 1 (sTNFR1) is associated with increased total mortality due to cancer and cardiovascular causes – Findings from two community based cohorts of elderly

Prognostic Utility of Soluble TREM‐1 in Predicting Mortality and Cardiovascular Events in Patients With Acute Myocardial Infarction

Effect of resistance training on C-reactive protein, blood glucose and lipid profile in older women with differing levels of RT experience

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