Inflammatory Markers: Exhaled Nitric Oxide and Carbon Monoxide During the Ovarian Cycle

Antczak, Adam; Ciebiada, Maciej; Kharitonov, Sergei A.; Górski, Paweł; Barnes, Peter J.

doi:10.1007/s10753-011-9345-1

Cited by 11 publications

(10 citation statements)

References 40 publications

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“…The gender effect may be due to more heavy smokers in the male group, as heavy smokers tend to have a higher concentration of COHb [3,24,45]. Moreover, some studies showed that females may have lower exhaled CO concentrations during menstruation due to loss of blood, which has a high affinity with CO [46]. The baseline exhaled CO concentration was positively associated with the number of cigarettes smoked daily and weekly, similar to other studies [20,24,26,39,43].…”

Section: Discussionsupporting

confidence: 77%

Can Exhaled Carbon Monoxide Be Used as a Marker of Exposure? A Cross-Sectional Study in Young Adults

Pan

Leonardi

Ucci

et al. 2021

IJERPH

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Carbon monoxide (CO) poisoning is a major public health issue worldwide. People are exposed to CO in their daily lives, with one of the common sources of CO being cigarette smoking. Inhalation of CO leads to elevated carboxyhaemoglobin (COHb) levels in the blood and also in exhaled CO concentration. Several factors have been shown to affect COHb concentration and COHb half-life. However, factors affecting exhaled CO concentration and exhaled CO half-life are not well understood. The present study aimed to investigate the potential factors related to baseline exhaled CO concentration and exhaled CO half-life among smokers. A cross-sectional study was conducted between 26 January and 30 June 2019, and young adults were recruited into the study. A total of 74 participants (mean age: 27.1 years, 71.6% males and 28.4% females) attended the study. They were invited to complete a questionnaire, including demographic, physiological, and behavioural factors. Then, exhaled CO measurements were taken. These measurements were taken before and after smoking a single cigarette for smokers and only once for non-smokers. The average baseline exhaled CO concentration was 6.9 ± 4.9 ppm for smokers and 1.9 ± 0.5 ppm for non-smokers. The mean of exhaled CO half-life was around 273.3 min (4.6 h) for smokers. No difference was seen in exhaled CO half-life between light smokers and heavy smokers in the smoking group. Gender and cigarettes smoked weekly affected baseline exhaled CO in smokers. Even though height seemed to positively associate with exhaled CO half-life, the relationship disappeared when adjusting by gender and weight. Therefore, exhaled CO could be used as a marker of CO exposure, but we cannot ignore the factors mentioned in the study. For future study, considering factors related to smoking habits and smoking style are recommended as these may affect total inhaled CO.

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Section: Discussionsupporting

confidence: 77%

Can Exhaled Carbon Monoxide Be Used as a Marker of Exposure? A Cross-Sectional Study in Young Adults

Pan

Leonardi

Ucci

et al. 2021

IJERPH

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“…Recent studies indicate that eCO values may be slightly impacted by acute hyperventilation [137]. Interestingly, eCO may fluctuate with the ovarian cycle in women [138]. eCO levels increased after ovulation peaked in the premenstrual phase, whereas eNO values peaked at mid-cycle [138].…”

Section: Carbon Monoxide In Exhaled Breathmentioning

confidence: 99%

“…Interestingly, eCO may fluctuate with the ovarian cycle in women [138]. eCO levels increased after ovulation peaked in the premenstrual phase, whereas eNO values peaked at mid-cycle [138]. …”

Section: Carbon Monoxide In Exhaled Breathmentioning

confidence: 99%

Carbon monoxide in exhaled breath testing and therapeutics

2013

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Carbon monoxide (CO), a low molecular weight gas, is a ubiquitous environmental product of organic combustion, which is also produced endogenously in the body, as the byproduct of heme metabolism. CO binds to hemoglobin, resulting in decreased oxygen delivery to bodily tissues at toxicological concentrations. At physiological concentrations, CO may have endogenous roles as a potential signaling mediator in vascular function and cellular homeostasis. Exhaled CO (eCO), similar to exhaled nitric oxide (eNO), has been evaluated as a candidate breath biomarker of pathophysiological states, including smoking status, and inflammatory diseases of the lung and other organs. eCO values have been evaluated as potential indicators of inflammation in asthma, stable COPD and exacerbations, cystic fibrosis, lung cancer, or during surgery or critical care. The utility of eCO as a marker of inflammation, and potential diagnostic value remains incompletely characterized. Among other candidate “medicinal gases” with therapeutic potential, (e.g., NO and H2S), CO has been shown to act as an effective anti-inflammatory agent in preclinical animal models of inflammatory disease, acute lung injury, sepsis, ischemia/reperfusion injury and organ graft rejection. Current and future clinical trials will evaluate the clinical applicability of this gas as a biomarker and/or therapeutic in human disease.

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“…Due to an increase in erythrocytes' catabolism, reticulocyte counts, and nitric oxide (NO) and progesterone expression and activation of heme oxygenase 1 (HO-1), particularly in the myometrial, vascular endothelial and smooth muscle cells, the production of endogenous carbon monoxide (CO) is elevated during the luteal phase of the menstrual cycle, providing protection against the endothelial oxidative stress. NO levels augment in the midcycle (74).…”

Section: Inflammatory Responses During Menstruationmentioning

confidence: 95%

Primary Dysmenorrhea: pathophysiology

2021

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The present study was conducted to investigate and analyze the recent and relevant studies about primary dysmenorrhea and its pathophysiology. Literature searches were performed electronically in PubMed, Medline, ISI, DOAJ, Springer, Embase. Web of Knowledge, DOAJ, Google Scholar and the Cochrane Library for original articles written in English and in Scielo, Lantidex, Imbiomed-L, Redalyc and Google Scholar for original articles written in Spanish. The searches included the key words (Mesh): menstruation, menstrual period, menstrual cycle, dysmenorrhea, primary dysmenorrhea, inflammatory substance and inflammatory markers. Publications from January 1980 to February 2021 were reviewed. Dysmenorrhea is the most common gynecologic condition experienced by menstruating women. It is characterized by crampy lower abdominal pain that can range widely in severity, and associated to others symptoms. Its overall impact often has significant medical and psychosocial implications. The hallmark of primary dysmenorrhea is painful menses in the absence of any associated macroscopic pathologic process, and it occurs in up to 50% of menstruating females and causes significant disruption in quality of life and absenteeism. An excessive or imbalanced amount of prostanoids and possibly eicosanoids released from the endometrium during menstruation have been mentioned as the main cause of primary dysmenorrhea. The uterus is induced to contract frequently and dysrhythmically, with increased basal tone and increased active pressure. Uterine hypercontractility, reduced uterine blood flow and increased peripheral nerve hypersensitivity induce pain. Diagnosis rests on a good history with negative pelvic evaluation findings. This narrative review investigated and analyzed the pathophysiology of primary dysmenorrhea and the implications of other chemical substances.

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Inflammatory Markers: Exhaled Nitric Oxide and Carbon Monoxide During the Ovarian Cycle

Cited by 11 publications

References 40 publications

Can Exhaled Carbon Monoxide Be Used as a Marker of Exposure? A Cross-Sectional Study in Young Adults

Can Exhaled Carbon Monoxide Be Used as a Marker of Exposure? A Cross-Sectional Study in Young Adults

Carbon monoxide in exhaled breath testing and therapeutics

Primary Dysmenorrhea: pathophysiology

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