Inflammatory markers in acute myocardial infarction and the correlation with the severity of coronary heart disease

Abstract

Introduction: The inflammatory hypothesis of atherosclerosis is appealing in acute coronary syndromes, but the dynamics and precise role are not established.Objectives: The study investigates the levels of C reactive protein (CRP), interleukin 1b (IL-1b) and stromal-derived factor 1a (SDF-1a) at the time of acute myocardial infarction (AMI) and at 1 and 6 months afterwards, compared with a control group. Results: In the acute phase of AMI, CRP and SDF-1a were significantly higher, while IL-1b showed lower levels compared with controls. CRP positively correlated with coronary stenosis severity (rho ¼ 0.3, p¼.05) and negatively related with left ventricle ejection fraction (LVEF) at 1 month (rho¼ À0.43, p¼.05). IL-1b weakly correlated with the severity of coronary lesions (rho ¼0.29, p¼.02) and strongly with LVEF (rho¼ À0.8, p¼.05). SDF-1a, slightly correlated with LVEF at 1 month (rho ¼ 0.22, p¼.01) and with the severity of coronary atherosclerosis (rho¼ À0.41, p¼.003). Conclusions: CRP, IL-1b and SDF-1a have important dynamic in the first 6 months after AMI and CRP and SDF-1a levels correlated with the severity of coronary lesions and LVEF at 1 month after the acute ischaemic event.

Synergistic Effects of Lotus Seed Resistant Starch and Sodium Lactate on Hypolipidemic Function and Serum Nontargeted Metabolites in Hyperlipidemic Rats

“…Cardiovascular diseases account for more than 30% of deaths from noncommunicable diseases worldwide. Hyperlipidemia is the primary risk factor for atherosclerosis, which is the pathological basis for coronary heart disease, cerebral thrombosis, and other ischemic heart and brain diseases. , The risk of hyperlipidemia increases with age or with long-term irregular and unhealthy eating habits. Hyperlipidemia, as a common metabolic disease, can lead to cardiovascular, liver, and other “age-related” diseases.…”

Nomogram for Predicting the Severity of Coronary Artery Disease in Young Adults ≤45 Years of Age with Acute Coronary Syndrome

“…Tajfard et al reported that elevated serum hs-CRP levels are significantly associated with the angiographic severity of CAD [31]. Oprescu et al have also found that CRP positively correlates with coronary stenosis severity (r = 0.3, P = 0.05) [32]. However, the nonconventional RFs, such as lipoprotein (a) and homocysteine, were not associated with the severity of CAD in our study, possibly because of differences among participants involved in our study compared with prior studies.…”

Significance of C-Reactive Protein in Patients with ST-Elevation Myocardial Infarction Over Non-ST-Elevation Myocardial Infarction

“…5 Myocardial infarction is usually diagnosed clinically or by studying the electrical activity of the heart, but still, the role of biochemical markers is established and used in clinical practice. 6 Habib et al 2011 conducted a study to compare different bio-chemical markers in STEMI and NSTEMI. They revealed that levels of CRP were found more raised in patients with MI with ST-segment elevation than those who did not show ST-segment elevation at electrocardiogram.…”