Inflammatory microenvironment in the initiation and progression of bladder cancer

Sui, Xinbing; Lei, Liming; Chen, Liuxi; Xie, Tian; Li, Xue

doi:10.18632/oncotarget.21565

Cited by 71 publications

(50 citation statements)

References 160 publications

(159 reference statements)

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“…Although a clear explanation to the non-reaction of NMR skin to IMQ could not be adduced, our results a rm the exceptional and unique nature of NMR in ammation/immunity. Furthermore, in ammation has been established as a hallmark of cancer [49][50][51] and it is therefore likely that the unique in ammatory/immunosurveillance mechanism exhibited by this animal could also be a contributor to its resistance to cancer.…”

Section: Discussionmentioning

confidence: 99%

Imiquimod does not elicit inflammatory responses in the skin of the naked mole rat (Heterocephalus glaber)

Kisipan

Ojoo

Kanui

et al. 2020

Preprint

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Objective: Naked mole rat (Heterocephalus glaber) has recently attracted interest in biomedical research due to its exceptional longevity, cancer resistance and tolerance to potentially harmful conditions or stimuli. Given its unique attributes, this study was designed to characterize inflammatory skin reactions of this animal to topical application of imiquimod, a toll-like receptor 7 and 8 agonist that triggers psoriasis-like skin reaction. Results: Imiquimod did not cause the expected psoriasis-like skin changes. There was no epidermal thickening and a straight epidermo-dermal boundary was maintained. There was no parakeratosis and the granular layer of epidermis was well formed. In the dermis, there was no leukocyte infiltration. This points to an exceptional nature of inflammatory/immune responses of this animal, but the mechanism could not be explained by our results. Naked mole rat could be a valuable negative model for studying psoriasis and other inflammatory skin conditions but as a prerequisite, there is need for further investigations to establish the mechanisms behind its lack of response to imiquimod.

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Section: Discussionmentioning

confidence: 99%

Imiquimod does not elicit inflammatory responses in the skin of the naked mole rat (Heterocephalus glaber)

Kisipan

Ojoo

Kanui

et al. 2020

Preprint

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“…Chronic inflammation plays an important role in cancer. The link between inflammation and development of bladder cancer has also been reported, and the oncogenic changes may potentiate inflammatory microenvironment that leads to angiogenesis and invasion of bladder cancer [31,32]. EGCG is a major constituent of green tea polyphenols that is documented as having antioxidant, anti-inflammatory, and anti-cancer effects [33].…”

Section: Discussionmentioning

confidence: 99%

Effects of Epigallocatechin Gallate (EGCG) on Urinary Bladder Urothelial Carcinoma―Next-Generation Sequencing and Bioinformatics Approaches

et al. 2019

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Background and objectives: Bladder urothelial carcinoma is the most common type of genitourinary cancer. Patients with bladder cancer may have limited treatment efficacy related to drug toxicity, resistance or adverse effects, and novel therapeutic strategies to enhance treatment efficacy or increase sensitivity to drugs are of high clinical importance. Epigallocatechin gallate (EGCG) is a polyphenolic compound found in green tea leaves, and a potential anti-cancer agent in various cancer types through modulating and regulating multiple signaling pathways. The current study aimed to explore the role and novel therapeutic targets of EGCG on bladder urothelial carcinoma. Materials and Methods: The BFTC-905 cells, human urinary bladder transitional cell carcinoma (TCC) cell line, were treated with EGCG or water for 24 hours, and the expression profiles of mRNAs and microRNAs were analyzed using next generation sequencing (NGS). The enriched biological functions were determined using different bioinformatics databases. Results: A total of 108 differentially expressed genes in EGCG-treated bladder TCC cells were identified, which were mainly involved in nicotinamide adenine dinucleotide (NAD) biogenesis, inflammatory response and oxidation-reduction metabolism. Moreover, several microRNA-mRNA interactions that potentially participated in the response of bladder TCC to EGCG treatment, including miR-185-3p-ARRB1 (arrestin beta 1), miR-3116-MGAT5B (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B), miR-31-5p-TNS1 (tensin 1), miR-642a-5p-TNS1, miR-1226-3p-DLG2 (discs large homolog 2), miR-484-DLG2, and miR-22-3p-PPM1K (protein phosphatase 1K). Conclusions: The current findings provide insights into novel therapeutic targets and underlying mechanisms of action of EGCG treatment in bladder cancer.

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“…The role of the cells of the immune system in the local immune reactions, both during the inflammation and neoplasia is described in details [2,13]. It is reported about the correlation between the composition of the immune microenvironment and the course of the disease or the development of the tumors in people who live in the polluted areas [12].…”

Section: Discussionmentioning

confidence: 99%

Variability of T-Lymphocytes and Macrofags Composition in the Urinary Bladder Under the Influence of Heavy Metals Salts, Correction of Their Effect With Vitamin E and in the Readaptation Period

Sikora

2018

Rep. of Morph.

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In modern urology, it is important to study and understand the features of the development of various pathologies in the organs of the urinary system since the disturbances of the urodynamics is a widespread problem all over the world. Thus, the environment pollution caused by heavy metal salts has unpredictable consequences for the functioning of the urinary bladder. That is why the object of this study is to determine the features of the expression and the quantitative composition of T-cells and macrophages in the UB wall under the intake of the HMS and correction of their effect with vitamin E, as well as during the readaptation period. According to the experimental scenario, the experiment model was implemented by using male rats that were divided into six groups. The heavy metal salts mixture consisted of the most common potentially dangerous metals-microelements (zinc, cooper, iron, manganese, lead and chrome). Vitamin E was chosen as a corrector. To determine the quantitative composition of T-cells and macrophages the immunohistochemical identification by CD3 and CD68 antibodies was used. The main results are presented as M±SD, with the assessment of the differences and dependencies between the groups by using nonparametric Mann-Whitney U test and Spearman’s Rank Correlation Coefficient. We found that the number of CD3+ lymphocytes and CD68+ macrophages differed between the groups and depended on the experimental conditions. Thus, the results of our study demonstrate that the number of T-cells and macrophages in the bladder increases under the influence of heavy metals salts. The simultaneous intake of the pollutants and vitamin E is accompanied by the decrease of expression intensity of the corresponding cells. When the intake of the heavy metals is canceled, the qualitative composition of the identified CD3 and CD68 cells gradually comes to the norm, but the speed of its reduction differs depending on the group of the readaptation. Discovered that the decrease of T-cells and macrophages in the groups with the use of vitamin E was more approached to the control. Based on the results of the immunohistochemical study, a strong correlation between an increased number of the expressed T-cells and macrophages was revealed in the urinary bladder during the whole period of the study that demonstrates the dependence of their activity.

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Inflammatory microenvironment in the initiation and progression of bladder cancer

Cited by 71 publications

References 160 publications

Imiquimod does not elicit inflammatory responses in the skin of the naked mole rat (Heterocephalus glaber)

Imiquimod does not elicit inflammatory responses in the skin of the naked mole rat (Heterocephalus glaber)

Effects of Epigallocatechin Gallate (EGCG) on Urinary Bladder Urothelial Carcinoma―Next-Generation Sequencing and Bioinformatics Approaches

Variability of T-Lymphocytes and Macrofags Composition in the Urinary Bladder Under the Influence of Heavy Metals Salts, Correction of Their Effect With Vitamin E and in the Readaptation Period

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