Inflammatory Microenvironment of Skin Wounds

Wang, Zhen; Fang, Qi; Luo, Hongchang; Xu, Guangchao; Wang, Dali

doi:10.3389/fimmu.2022.789274

Cited by 63 publications

(47 citation statements)

References 172 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The microenvironment of the infectious wound region is complicated and changes at different stages. − Initially, the existence of bacteria, as exogenous stimuli, leads to accumulative production of destructive enzymes and toxins, which cause long-term inflammation and delayed wound healing . The second stage which is inflammation features highly expressive M1 phenotype macrophages, which deteriorate the local recovery. , Overproduced ROS levels exacerbate local inflammation and reduce angiogenesis. , The late stage is the proliferation stage, during which cells migrate to the wound area and newborn vessels generate . Nutrition is brought to the defect region through vessels, benefitting the repair process.…”

Section: Introductionmentioning

confidence: 99%

“…7 The second stage which is inflammation features highly expressive M1 phenotype macrophages, which deteriorate the local recovery. 8,9 Overproduced ROS levels exacerbate local inflammation and reduce angiogenesis. 10,11 The late stage is the proliferation stage, during which cells migrate to the wound area and newborn vessels generate.…”

Section: ■ Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Logic-Based Diagnostic and Therapeutic Nanoplatform with Infection and Inflammation Monitoring and Microenvironmental Regulation Accelerating Wound Repair

Liu

Wang

et al. 2022

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Infectious cutaneous wounds are a thorny clinical problem. The microenvironment of the infectious wound is complicated and changes at different healing stages. Traditional treatments either have a single effect such as anti-inflammation, antibacteria, or angiogenesis or a simple mixture of several functions. They fail to deal with the change of the physiological healing process, leading to unsatisfactory outcomes. Herein, we have designed a logic-based smart nanoplatform (named as ZEM), aiming to self-monitor the wound microenvironment and accordingly react to the changes of the healing process, fitting multiple needs of physiological repair at different stages. ZEM was synthesized using zeolitic imidazolate framework-8 (ZIF-8) coated with an epigallocatechin gallate (EGCG)/Mg2+ complex. We characterized ZEM in the aspects of morphology, physical and chemical properties, and ion release pattern. At the initial stage, ZEM sensed the weakly acidic environment and responsively released a large number of zinc ions to eliminate bacterial infection. Then came the second inflammation stage, where ZEM responded to the oxidative stress of the local wound area with EGCG absorbing excessive reactive oxygen species (ROS), contributing to the downregulation of intracellular ROS. Meanwhile, local inflammation was alleviated by reducing the expression of proinflammatory M1 phenotype factors (IL-6, TNF-α, and IL-1β). Since the balance of local ROS had been achieved, the resulting disintegration of the EGCG/Mg2+ complex gave rise to the sustainable release of Mg2+ at the proliferation stage, promoting vascularized healing. In vivo animal experiments further proved the diagnostic and therapeutic functions of ZEM. All these results demonstrated that ZEM was a promising treatment strategy in soft tissue engineering.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Logic-Based Diagnostic and Therapeutic Nanoplatform with Infection and Inflammation Monitoring and Microenvironmental Regulation Accelerating Wound Repair

Liu

Wang

et al. 2022

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“… 16 Some of the well‐known underlying molecular mechanisms are fibroblast‐to‐myofibroblast differentiation, as well as activation of inflammatory components. 17 , 18 The repair of damaged tissue produces paracrine signals, which results in the activation of myofibroblast differentiation. 17 Transforming growth factor‐beta (TGF‐β) is the most important signal during this process.…”

Section: The Molecular Mechanisms Behind the Microenvironment In Tumo...mentioning

confidence: 99%

“…Involvement of TME and cells of TME, which are known as the stroma, reactive stroma, and cancer‐associated fibroblasts (CAFs; also known as tumor stromal fibroblasts) during wound healing is a key event in tumorigenesis 16 . Some of the well‐known underlying molecular mechanisms are fibroblast‐to‐myofibroblast differentiation, as well as activation of inflammatory components 17,18 . The repair of damaged tissue produces paracrine signals, which results in the activation of myofibroblast differentiation 17 .…”

Section: The Molecular Mechanisms Behind the Microenvironment In Tumo...mentioning

confidence: 99%

The role of the tumor microenvironment in colorectal cancer and the potential therapeutic approaches

Zafari

Khosravi

Rezaee

et al. 2022

Clinical Laboratory Analysis

View full text Add to dashboard Cite

Background: Colorectal cancer (CRC) with a high prevalence is recognized as the fourth most common cause of cancer-related death globally. Over the past decade, there has been growing interest in the network of tumor cells, stromal cells, immune cells, blood vessel cells, and fibroblasts that comprise the tumor microenvironment (TME) to identify new therapeutic interventions.Methods: Databases, such as Google Scholar, PubMed, and Scopus, were searched to provide an overview of the recent research progress related to targeting the TME as a novel therapeutic approach.Results: Tumor microenvironment as a result of the cross talk between these cells may result in either advantages or disadvantages in tumor development and metastasis, affecting the signals and responses from the surrounding cells. Whilst chemotherapy has led to an improvement in CRC patients' survival, the metastatic aspect of the disease remains difficult to avoid. Conclusions:The present review emphasizes the structure and function of the TME, alterations in the TME, its role in the incidence and progression of CRC, the effects on tumor development and metastasis, and also the potential of its alterations as therapeutic targets. It should be noted that providing novel studies in this field of research might help us to achieve practical therapeutic strategies based on their interaction.

show abstract

“…Upon injury, the process of tissue repair is initiated, during which recruited immune cells migrate through ECM to reach the target location. Inflammation and resolution of wound healing processes are regulated by contribution of (infiltrating) immune cells ( Volk et al, 2013 ; Manon-Jensen et al, 2016 ; Wang et al, 2022 ). It is likely that their migration, in these lung diseases, through aberrant ECM will affect the function of the infiltrating immune cells.…”

Section: Introductionmentioning

confidence: 99%

Highway to heal: Influence of altered extracellular matrix on infiltrating immune cells during acute and chronic lung diseases

Joglekar

Nizamoglu²,

Fan³

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Environmental insults including respiratory infections, in combination with genetic predisposition, may lead to lung diseases such as chronic obstructive pulmonary disease, lung fibrosis, asthma, and acute respiratory distress syndrome. Common characteristics of these diseases are infiltration and activation of inflammatory cells and abnormal extracellular matrix (ECM) turnover, leading to tissue damage and impairments in lung function. The ECM provides three-dimensional (3D) architectural support to the lung and crucial biochemical and biophysical cues to the cells, directing cellular processes. As immune cells travel to reach any site of injury, they encounter the composition and various mechanical features of the ECM. Emerging evidence demonstrates the crucial role played by the local environment in recruiting immune cells and their function in lung diseases. Moreover, recent developments in the field have elucidated considerable differences in responses of immune cells in two-dimensional versus 3D modeling systems. Examining the effect of individual parameters of the ECM to study their effect independently and collectively in a 3D microenvironment will help in better understanding disease pathobiology. In this article, we discuss the importance of investigating cellular migration and recent advances in this field. Moreover, we summarize changes in the ECM in lung diseases and the potential impacts on infiltrating immune cell migration in these diseases. There has been compelling progress in this field that encourages further developments, such as advanced in vitro 3D modeling using native ECM-based models, patient-derived materials, and bioprinting. We conclude with an overview of these state-of-the-art methodologies, followed by a discussion on developing novel and innovative models and the practical challenges envisaged in implementing and utilizing these systems.

show abstract

Inflammatory Microenvironment of Skin Wounds

Cited by 63 publications

References 172 publications

Logic-Based Diagnostic and Therapeutic Nanoplatform with Infection and Inflammation Monitoring and Microenvironmental Regulation Accelerating Wound Repair

Logic-Based Diagnostic and Therapeutic Nanoplatform with Infection and Inflammation Monitoring and Microenvironmental Regulation Accelerating Wound Repair

The role of the tumor microenvironment in colorectal cancer and the potential therapeutic approaches

Highway to heal: Influence of altered extracellular matrix on infiltrating immune cells during acute and chronic lung diseases

Contact Info

Product

Resources

About